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| 1 | Hepatitis B in pregnancy显示文摘Chronic hepatitis B virus (HBV) infection affects about 350 million individuals worldwide. Management of HBV infection in pregnancy is difficult because of several peculiar and somewhat controversial aspects. The aim of the present review is to provide a tool that may help physicians to correctly manage HBV infection in pregnancy. This review focuses on (1) the effect of pregnancy on HBV infection and of HBV infection on pregnancy; (2) the potential viral transmission from mother to newborn despite at-birth prophylaxis with immunoglobulin and vaccine; (3) possible prevention of mother-to-child transmission through antiviral drugs, the type of antiviral drug to use considering their efficacy and potential teratogenic effect, and the timing of their administration and discontinuation; and (4) the evidence for the use of elective caesarean section vs vaginal delivery and the possibility of breastfeeding. | Guglielmo Borgia Maria Aurora Carleo Giovanni Battista Gaeta Ivan Gentile | 2012 | World Journal of Gastroenterology2012，18，34： | 16 |
| 2 | Current concepts and future strategies in the antimicrobial therapy of emerging Gram-positive spontaneous bacterial peritonitis显示文摘Spontaneous bacterial peritonitis(SBP) is the most common infection in end-stage liver disease patients.SBP is defined as an ascitic fluid infection with a polymorphonuclear leucocyte count ≥ 250/mm^3 without an evident intra-abdominal surgically treatable source.Several mechanisms contribute to SBP occurrence,including translocation of gut bacteria and their products,reduced intestinal motility provoking bacterial overgrowth,alteration of the gut's barrier function and local immune responses.Historically,Gram-negative enteric bacteria have been the main causative agents of SBP,thereby guiding the empirical therapeutic choice.However,over the last decade,a worryingly increasing prevalence of Gram-positive and multi-drug resistant(MDR) SBP has been seen.Recently,the microbiological spectrum of SBP seems to have changed in Europe due to a high prevalence of Gram-positive bacteria(48%-62%).The overall proportion of MDR bacteria is up to 22%-73% of cases.Consequently,empirical therapy based on thirdgeneration cephalosporins or amoxicillin/clavulanic acid,can no longer be considered the standard of care,as these drugs are associated with poor outcomes.Theaim of this review is to describe,with an epidemiological focus,the evidence behind this rise in Gram-positive and MDR SBP from 2000 to present,and illustrate potential targeted therapeutic strategies.An appropriate treatment protocol should include daptomycin plus ceftaroline and meropenem,with prompt stepdown to a narrower spectrum when cultures and sensitivity data are available in order to reduce both cost and potential antibiotic resistance development. | Marco Fiore Alberto Enrico Maraolo Ivan Gentile Guglielmo Borgia Sebastiano Leone Pasquale Sansone Maria Beatrice Passavanti Caterina Aurilio Maria Caterina Pace | 2017 | World Journal of Hepatology2017，9，30： | 13 |
| 3 | Nosocomial spontaneous bacterial peritonitis antibiotic treatment in the era of multi-drug resistance pathogens: A systematic review显示文摘AIM To systematically review literature upon aetiology of nosocomial spontaneous bacterial peritonitis(N-SBP) given the rising importance of multidrug-resistant(MDR) bacteria.METHODS A literature search was performed on MEDLINE and Google Scholar databases from 2000 to 15 th of November 2016, using the following search strategy: 'spontaneous' AND 'peritonitis'.RESULTS The initial search through electronic databases retrieved 2556 records. After removing duplicates, 1958 records remained. One thousand seven hundred and thirty-five of them were excluded on the basis of the screening of titles and abstract, and the ensuing number of remaining articles was 223. Of these records, after careful evaluation, only 9 were included in the qualitative analysis. The overall proportion of MDR bacteria turned out to be from 22% to 73% of cases across the studies.CONCLUSION N-SBP is caused, in a remarkable proportion, by MDR pathogens. This should prompt a careful re-assessment of guidelines addressing the treatment of this clinical entity. | Marco Fiore Alberto Enrico Maraolo Ivan Gentile Guglielmo Borgia Sebastiano Leone Pasquale Sansone Maria Beatrice Passavanti Caterina Aurilio Maria Caterina Pace | 2017 | World Journal of Gastroenterology2017，23，25： | 9 |
| 4 | Daclatasvir: The First of a New Class of Drugs Targeted Against Hepatitis C Virus NS5A显示文摘 | I. Gentile F. Borgia N. Coppola A.R. Buonomo G. Castaldo G. Borgia | 2014 | Current Medicinal Chemistry2014，，12： | 3 |
| 5 | A Novel Promising Therapeutic Option Against Hepatitis C Virus: An Oral Nucleotide NS5B Polymerase Inhibitor Sofosbuvir显示文摘 | I. Gentile F. Borgia A. R. Buonomo G. Castaldo G. Borgia | 2013 | Current Medicinal Chemistry2013，，30： | 3 |
| 6 | Bioaccumulation Factors for PCBs Revisited显示文摘 | Borgia K Fisk A T Hargrave B Y | 2005 | Environmental Science & Technology2005，39，： | 1 |
| 7 | Targeting the insulin-like growth factor receptor pathway in lung cancer:problems and pitfalls显示文摘 | Fidler MJ Shersher DD Borgia JA | 2012 | Ther Adv Med Oncol2012，4，2： | 1 |
| 8 | Numerical simulation of salt precipitation in the fractures of a C02 enhanced geothermal system显示文摘 | Borgia A Pruess K Kneafsey T J | 2012 | Geothermics2012，44，： | 1 |
| 9 | Differential modulation of human melanoma cell metallop roteinase expression by alpha2betal integrin and CD44 trip le2helical ligands derived from type IV collagen 显示文摘 | Baronas-Lowell D Lauer-Fields J L Borgia J A | 2004 | J Biol Chem2004，279，43： | 1 |
| 10 | Developments in core analysis by NMR measurements 显示文摘 | Borgia G C Bortolotti V Brancolini A | 1996 | Magnet Resonance Imaging1996，14，78： | 1 |
| 11 | Water- air saturation changes in rest ricted geometries studied by proton relaxation显示文摘 | Borgia G C Brancolini A Brown R J S | 1994 | Magn Reson Imag1994，12，2： | 1 |
| 12 | Intraoperative aorta balloon occlusion: fertility preservation in patients with placenta previa accreta/increta 显示文摘 | Panici PB Anceschi M Borgia ML | 2012 | J Matern Fetal Neonatal Med2012，25，12： | 1 |
| 13 | Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain- induced model of joint damage and repair 显示文摘 | Panicker S Borgia J Fhied C | 2009 | Osteoarthritis Cartilage2009，17，： | 1 |
| 14 | Telaprevir: A prom-ising protease inhibitor for the treatment of hepatitis G virusinfec-tion显示文摘 | GENTILE I VIOLA C BORGIA F | 2009 | Curr Med Chem2009，16，9： | 1 |
| 15 | Treating chronic hepatitis B:today and tomorrow显示文摘 | Borgia G Gentile I | 2006 | Curr Med Chem2006，13，23： | 1 |
| 16 | Central Serous Chorioretinopathy and Indocyanine Green Angiography显示文摘 | Piceolino F C Borgia L | 1994 | Retina1994，14，3： | 1 |
| 17 | Indocynine green angiographyof circumscribed choroidal hemangiomas 显示文摘 | Piccdino FC Borgia L Zinicda E | 1996 | Retina1996，，： | 1 |
| 18 | Indocyanine Green Angiographic Findings in Central Serous Chorioretinopathy 显示文摘 | Piccolino F C Borgia L Zinicola E | 1995 | Eye1995，9，3： | 1 |
| 19 | Treating chronic hepatitis B:today and tomorrow 显示文摘 | BORGIA G GENTILE I | 2006 | Curr Med Chem2006，，23： | 1 |
| 20 | Cortisol circadian rhythm and 24--hour Holter arterial pressure in OSAS patients 显示文摘 | Parlapiano C Borgia MC Minni A | 2005 | Endocr Res2005，31，4： | 1 |
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