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| 1 | Adenomyomatosis of the gallbladder in childhood: A systematic review of the literature and an additional case report显示文摘AIM: To investigate the diagnostic and therapeutic assessment in children with adenomyomatosis of the gallbladder(AMG).METHODS: AMG is a degenerative disease characterized by a proliferation of the mucosal epithelium which deeply invaginates and extends into the thickened muscular layer of the gallbladder, causing intramural diverticula. Although AMG is found in up to 5% of cholecystectomy specimens in adult populations, this condition in childhood is extremely uncommon. Authors provide a detailed systematic review of the pediatric literature according to PRISMA guidelines, focusing on diagnostic and therapeutic assessment. An additional case of AMG is also presented. RESULTS:Five studies were finally enclosed, encompassing 5 children with AMG. Analysis was extended to our additional 11-year-old patient, who presented diffuse AMG and pancreatic acinar metaplasia of the gallbladder mucosa and was successfully managed with laparoscopic cholecystectomy. Mean age at presentation was 7.2 years. Unspecific abdominal pain was the commonest symptom. Abdominal ultrasound was performed on all patients, with a diagnostic accuracy of 100%. Five patients underwent cholecystectomy, and at follow-up were asymptomatic. In the remaining patient, completely asymptomatic at diagnosis, a conservative approach with monthly monitoring via ultrasonography was undertaken. CONCLUSION: Considering the remote but possible degeneration leading to cancer and the feasibility of laparoscopic cholecystectomy even in small children, evidence suggests that elective laparoscopic cholecystectomy represent the treatment of choice. Preoperative evaluation of the extrahepatic biliary tree anatomy with cholangio-MRI is strongly recommended. | Filippo Parolini Giuseppe Indolfi Miguel Garcia Magne Marianna Salemme Maurizio Cheli Giovanni Boroni Daniele Alberti | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 6 |
| 2 | Inflammatory fibroid polyps in children:A new case report and a systematic review of the pediatric literature显示文摘AIM: To study that inflammatory fibroid polyps(IFPs) in children are extremely uncommon tumors that may occur throughout the gastrointestinal tract. METHODS: A systematic review of the pediatric literature and a report of a new case of IFP is also pres-ented. The Pub Med database was searched for original studies on pediatric IFPs since 1960, according to 'Preferred reporting items for systematic reviews and meta-analyses' guidelines for systematic reviews. RESULTS: Five studies were finally enclosed, encompassing 6 children with IFPs(mean age 64 mo). Tumors were located in the stomach(2 patients), in the small bowel(2 patients), in the rectum(1 patient) and in the colon(1 patient). Open surgery was performed in all patients and complete excision of the mass was achieved in all cases. All patients are alive and free of symptom. Authors described a further case of a 3-year-old boy with a large duodenal IFP, in whom the tumor was removed by 'en block resection'. The presence of IFP throughout the gastrointestinal tract and its variable clinical appearances make it difficult to diagnose. An accurate pre-operative assessment is fundamental in order to differentiate IFP from other more aggressive gastrointestinal tumor, enabling unnecessary demolitive surgery. CONCLUSION: When complete resection of the IFP is achieved, the prognosis is excellent. | Laura Righetti Filippo Parolini Paolo Cengia Giovanni Boroni Maurizio Cheli Aurelio Sonzogni Daniele Alberti | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 5 |
| 3 | NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity显示文摘 | Pizzi M Sarnico I Boroni F | 2005 | Cell Death Differ2005，12，7： | 1 |
| 4 | Real-time aircraft radar simulator for a navy training sys- tem显示文摘 | D' AMATO J P GARCfA BAUZA C BORONI G | 2013 | Computer Applications in Engineering Educa- tion2013，21，4： | 1 |
| 5 | Nerve growth factor suppresses the transforming phenotype of human prolactinomas显示文摘 | Missale C Boroni F Losa M | 1993 | Prac Natl Acad Sci USA1993，90，： | 1 |
| 6 | Endoscopic treatment of periampullary duodenal duplication cysts in children: Four case reports and review of the literature显示文摘BACKGROUND Duodenal duplications are rare congenital anomalies of the gastrointestinal tract.As the periampullary variant is much rarer,literature is scant and only few authors have reported their experience in diagnosis and treatment,particularly with operative endoscopy.CASE SUMARY To report our experience with the endoscopic treatment in a series of children with periampullary duodenal duplication cysts,focusing on the importance of obtaining an accurate preoperative anatomic assessment of the malformations.The pediatric periampullary duodenal duplication cyst literature is reviewed.We conducted a systematic review according to the PRISMA guidelines.The PubMed database was searched for original studies on“duodenal duplication”,“periampullary duplication”or“endoscopic management”published since 1990,involving patients younger than 18 years of age.Eligible study designs were case report,case series and reviews.We analyzed the data and reported the results in table and text.Fifteen eligible articles met the inclusion criteria with 16 patients,and analysis was extended to our additional 4 cases.Median age at diagnosis was 13.5 years.Endoscopic treatment was performed in 10(50%)patients,with only 2 registered complications.CONCLUSION Periampullary duodenal duplication cysts in pediatric patients are very rare.Our experience suggests that an accurate preoperative assessment is critical.In the presence of sludge or stones inside the duplication,endoscopic retrograde cholangio-pancreatography is mandatory to demonstrate a communication with the biliary tree.Endoscopic treatment resulted in a safe,minimally invasive and effective treatment.In periampullary duodenal duplication cyst endoscopically treated children,long-term follow-up is still necessary considering the potential malignant transformation at the duplication site. | Anna Lavinia Bulotta Maria Vittoria Stern Dario Moneghini Filippo Parolini Maria Pia Bondioni Guido Missale Giovanni Boroni Daniele Alberti | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，10： | 1 |
| 7 | Nerve growth factor sup-presses the ransforming phenotype of human prolactinomas 显示文摘 | Missale C Boroni F Losa M | 1993 | Proceedings of the National Academy of Sciences1993，，90： | 1 |
| 8 | Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices显示文摘 | Pizzi M Sarnico I Boroni F | 2004 | Mol Cell Neurosci2004，25，2： | 1 |
| 9 | Chylothorax 显示文摘 | Migliori C Boroni G Milianti S | 2010 | Minerva Pediatr2010，62，3： | 1 |
| 10 | The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices显示文摘 | GOFFI F BORONI F BENARESE M | | 0，，： | 1 |
| 11 | Opposing roles for NF-kappaB/Rel factors p65 and c-Rel in the modulation of neuronal survival elicited by glutamate and interluelin-1 beta显示文摘 | Pizzi M Goffi F Boroni F | 2002 | J Biol Chem2002，277，20： | 1 |
| 12 | Nerve growth factor suppresses the transforming phenotype of human prolactinomas显示文摘 | Missale C Boroni F Losa M | 1993 | Prac Natl Acad Sci1993，90，： | 1 |
| 13 | Nerve growth factor and bromocriptine:a sequential therapy for human bromocriptine-resistant prolactinomas显示文摘 | Missale C Losa M Boroni F | 1995 | Brit J Cancer1995，72，： | 1 |
| 14 | Opposing roles for NF - KB/Rel factors p65 and c - Rel in the modulation of neuron survival elicited by glutamate and interleukin -1β 显示文摘 | Pizzi M Goffi F Boroni F | 2002 | Biol Chem2002，277，20： | 1 |
| 15 | NF-кB pathway:a target for preventing b-amyloid (Ab)-induced neuronal damage and Ab42 production显示文摘 | VALERIO A BORONI F BENARESE M | 2006 | Eur J Neur2006，23，： | 1 |
| 16 | Opposing roles for NF-kappa B! Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-lbeta显示文摘 | Pizzi M Goffi F Boroni F | 2002 | J Biol Chem2002，277，20： | 1 |
| 17 | prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slice显示文摘 | Pizzi M Samico I Boroni F | 2004 | Mol Cell Neurosci2004，25，2： | 1 |
| 18 | Nerve growth factor suppresses the transforming phenotype of human prolactinomas显示文摘 | Missale C Boroni F Losa M | 1993 | Proc Natl Acad Sci USA1993，90，： | 1 |
| 19 | Reversal of glutamate excitotoxicity by activation of PKC-associated metabotropic glutamate receptors in cerebellar granule cells relies on NR2C subunit expression显示文摘 | Pizzi M Boroni F Bianchetti KM | 1999 | Eur J Neurosci1999，11，： | 1 |
| 20 | Relationship between myocar- dial redox state and matrix metalloproteinase activity in patients on left ventricular assist device support显示文摘 | Caruso R Caselli C Boroni C | 2011 | Circ J2011，75，10： | 1 |
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