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| 1 | Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis显示文摘A large body of experimental and clinical data supports the notion that inflammation in acute pancreatitis has a crucial role in the pathogenesis of local and systemic damage and is a major determinant of clinical severity.Thus,research has recently focused on molecules that can regulate the inflammatory processes,such as phosphoinositide 3-kinases(PI3Ks),a family of lipid and protein kinases involved in intracellular signal transduction.Studies using genetic ablation or pharmacologic inhibitors of different PI3 K isoforms,in particular the class I PI3Kδ and PI3Kγ,have contributed to a greater understanding of the roles of these kinases in the modulation of inflammatory and immune responses.Recent data suggest that PI3 Ks are also involved in the pathogenesis of acute pancreatitis.Activation of the PI3K signaling pathway,and in particular of the class IB PI3Kγ isoform,has a significant role in those events which are necessary for the initiation of acute pancreatic injury,namely calcium signaling alteration,trypsinogen activation,and nuclear factor-κB transcription.Moreover,PI3Kγ is instrumental in modulating acinar cell apoptosis,and regulating local neutrophil infiltration and systemic inflammatory responses during the course of experimental acute pancreatitis.The availability of PI3 K inhibitors selective for specific isoforms may provide new valuable therapeutic strategies to improve the clinical course of this disease.This article presents a brief summary of PI3 K structure and function,and highlights recent advances that implicate PI3 Ks in the pathogenesis of acute pancreatitis. | Enrico Lupia Luca Pigozzi Alberto Goffi Emilio Hirsch Giuseppe Montrucchio | 2014 | World Journal of Gastroenterology2014，20，41： | 15 |
| 2 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 3 | Diagnostic accuracy and reproducibility of pleural and lung ultrasound in discriminating cardiogenic causes of acute dyspnea in the Emergency Department显示文摘 | Gian Alfonso Cibinel Giovanna Casoli Fabrizio Elia Monica Padoan Emanuele Pivetta Enrico Lupia Alberto Goffi | 2012 | Internal and Emergency Medicine2012，，1： | 2 |
| 4 | Ablation of phosphoinositide 3 - kinase gamma reduces the severity of acute panereatitis 显示文摘 | Lupia E Goffi A De Giuli P | 2004 | Am J Pathol2004，165，6： | 1 |
| 5 | Leukocyte response to injury显示文摘 | Goffi WG Burleson DG Pruitt B A | 1993 | Arch Surg1993，128，： | 1 |
| 6 | Ablation of phosphoinositide 3-kinase-y reduces the severity of acute pancrea/i/is显示文摘 | Lupia E Goffi A Azzolino O | 2004 | Am J Pathol2004，165，6： | 1 |
| 7 | Mechanical ventilation during acute lung injury: current recommendations and new concepts 显示文摘 | Del Goffi Ranieri | 2011 | Presse Medicale2011，40，122： | 1 |
| 8 | Ablation of phosphoinositide 3-kinase-γ reduces the severity of acute pancreatitis显示文摘 | Lupia E Goffi A De Giuli P | 2004 | Am J Pathol2004，165，6： | 1 |
| 9 | Ablation nase-gamma reduces the severity of acute pancreatitis 显示文摘 | Lupia E Goffi A De Giuli P | 2004 | Am J Patho12004，165，6： | 1 |
| 10 | Interleukin - 1 beta and glutamate activate the NF - kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures 显示文摘 | Grilli M Goffi F Memo M | 1996 | J Biol Chem1996，271，15： | 1 |
| 11 | The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices显示文摘 | GOFFI F BORONI F BENARESE M | | 0，，： | 1 |
| 12 | Mechanical ventilation during acute lung injury: current recommendations and new concepts显示文摘 | Del SL Goffi A Ranieri VM | 2011 | Pres- se Med2011，40，122： | 1 |
| 13 | Nutrient profiling: comparison and critical analysis of existing systems 显示文摘 | Azais-Braesco V Goffi C Labouze E | 2006 | Public Health Nutr2006，9，5： | 1 |
| 14 | Opposing roles for NF-kappaB/Rel factors p65 and c-Rel in the modulation of neuronal survival elicited by glutamate and interluelin-1 beta显示文摘 | Pizzi M Goffi F Boroni F | 2002 | J Biol Chem2002，277，20： | 1 |
| 15 | Lung Ultrasound-Implemented Diagnosis of Acute Decompensated Heart Failure in the ED显示文摘 | Emanuele Pivetta Alberto Goffi Enrico Lupia Maria Tizzani Giulio Porrino Enrico Ferreri Giovanni Volpicelli Paolo Balzaretti Alessandra Banderali Antonello Iacobucci Stefania Locatelli Giovanna Casoli Michael B. Stone Milena M. Maule Ileana Baldi Franco M | 2015 | Chest2015，，： | 1 |
| 16 | Day surgery for mucosal-hemorrhoidal prolapse using a circular stapler and modified regional anestnesia显示文摘 | Gaabrilli F chiarelli M Goffi U | 2001 | Dis Colon Rectum2001，44，： | 1 |
| 17 | Opposing roles for NF - KB/Rel factors p65 and c - Rel in the modulation of neuron survival elicited by glutamate and interleukin -1β 显示文摘 | Pizzi M Goffi F Boroni F | 2002 | Biol Chem2002，277，20： | 1 |
| 18 | Preoperative APACHE II and ASA scores in patients having major general surgical operations: prognostic value and potential clinical applications 显示文摘 | GOFFI L SABA V GHISELLI R | 1999 | Eur J Surg1999，165，8： | 1 |
| 19 | Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis显示文摘 | Lupia E Goffi A De Giuli P | 2004 | Am J Pathol2004，165，： | 1 |
| 20 | Opposing roles for NF-kappa B! Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-lbeta显示文摘 | Pizzi M Goffi F Boroni F | 2002 | J Biol Chem2002，277，20： | 1 |
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