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| 1 | Cell-free DNA integrity for the monitoring of breast cancer:Future perspectives?显示文摘Breast cancer(BC) is the most common cancer and the second cause of death in women worldwide. Therapeutic options are increasing, but the response to treatments is not always efficient and the risk of recurrence covers decades. In this perspective, the need to have a proper follow-up for the therapeutic responses and for anticipating recurrence it is urgent in the clinical setting. Liquid biopsy provides the basic principle for a non-invasive method for the routinely monitoring of BC. However, due to the heterogeneity of tumors during onset and progression, the search for tumor DNA mutations of targeted genes in plasma/serum is a limiting factor. A possible approach overtaking this problem comes from the measurement of cell-free DNA integrity, which is an independent factor from the mutational status and theoretically is representative of all tumors. This review summarizes the state-of-the-art of cell-free DNA integrity researches in BC, the controversies and the future perspective. | Navid Sobhani Daniele Generali Fabrizio Zanconati Marina Bortul Bruna Scaggiante | 2018 | World Journal of Clinical Oncology2018，9，2： | 2 |
| 2 | Increased OPG expression and impaired OPG/TRAIL ratio in the aorta of diabetic rats显示文摘 | Vaccarezza M Bortul R Fadda R | 2007 | Med Chem2007，3，4： | 1 |
| 3 | Breast adenocarcinoma MCF-7 cell line induces spontaneous osteoclastogenesis via a RANK-ligand-dependent pathway 显示文摘 | Nicolin V Bortul R Bareggi R | 2008 | Acta Histochem2008，110，5： | 1 |
| 4 | Indications for splenec- tomy in the surgical treatment of gastric cancer 显示文摘 | Bortul M Guarino G Calligaris L | 2001 | Chir Ital2001，53，4： | 1 |
| 5 | Binding of elements of protein kinase C-alpha regulatory domain to lamin B1显示文摘 | Tabellini G Bortul R Aluigi M | 2002 | Cell Signal2002，14，： | 1 |
| 6 | Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L)up-regulation显示文摘 | Bortul R Tazzari PL Cappellini A | 2003 | Leukemia2003，17，2： | 1 |
| 7 | Novel 2Csubstituted, 3Cdeoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway显示文摘 | Tabellini G Tazzari PL Bortul R | 2004 | Br J Haematol2004，126，4： | 1 |
| 8 | Deguelin, a PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway显示文摘 | Bortul R Tazzari PL Billi AM | 2005 | Br J Haematol2005，129，5： | 1 |
| 9 | Binding of elements of protein kinase C-alpha regulatory domain to lamin B1显示文摘 | Tabellini G Bortul R Aluigi M | 2002 | Cell Signal2002，14，10： | 1 |
| 10 | Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway 显示文摘 | Tabellini G Tazzari PL Bortul R | 2004 | Br J Haematol2004，126，： | 1 |
| 11 | Breast adenocarcinomaMCF-7 cell line induces spontaneous osteoclastogenesis via aRANK-ligand-dependent pathway 显示文摘 | Nicolin V Bortul R Bareggi R | 2008 | Acta Histoehem2008，110，5： | 1 |
| 12 | Blood transfusions and re- suits after curative resection forgastric cancer显示文摘 | Bortul M Calligaris L Roseano M | 2003 | Suppl Tumori2003，2，5： | 1 |
| 13 | Involvement of the phosphoinositide 3-kinase/Akt signaling pathway in the resistance to therapeutic treatments of human leukemias显示文摘 | Martelli AM Tabellini G Bortul R | 2005 | Histol Histopathol2005，20，1： | 1 |
| 14 | Gastric Wall Necrosis from Organo-axial Volvulus as a Late Complication of Laparoscopic Gastric Banding显示文摘 | Marina Bortul Monica Scaramucci Cinzia Tonello Arrigo Spivach Gennaro Liguori | 2004 | Obesity Surgery2004，，2： | 1 |
| 15 | Deguelin,A PI3K/AKT inhibitor,enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway显示文摘 | Bortul R Tazzari PL Billi AM | 2005 | Br J Haematol2005，129，5： | 1 |
| 16 | Increased OPG expression and impaired OPG/TRAIL ratio in the aorta of diabetic rats显示文摘 | Vaccarezza M Bortul R Fadda R | 2007 | Med Chem2007，3，4： | 1 |
| 17 | Phosphoinositide 3-kinase/Akt inhibition increases arsenic trioxide-induced apoptosis of acute promyelocytic and T-cell leukaemias显示文摘 | Tabellini G Tazzari PL Bortul R | 2005 | Br J Haematol2005，130，6： | 1 |
| 18 | Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-κB activation and cFLIPL up-regulation显示文摘 | Bortul R Tazzari PL Cappellini A | 2003 | Leukemia2003，17，2： | 1 |
| 19 | Blood transfusions and results after curative resection for gastric cancer显示文摘 | Bortul M Calligaris L Roseano M | 2003 | Suppl Tumori2003，2，5： | 1 |
| 20 | Phosphoinositide 3-kinase/Akt inhibition increases arsenic trioxide-induced apoptosis of acute promyelocytic and T-cell leukemias 显示文摘 | Tabellini G Tazzari PL Bortul R | 2005 | Br J Haematol2005，130，： | 1 |
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