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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | Plasmacytoid dendritic cells and Th17 immune response contribution in gastrointestinal acute graft-versus-host disease显示文摘 | Bossard C Malard F Gaugler B | 2012 | Leukemia2012，26，7： | 1 |
| 3 | 1 Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement 显示文摘 | GUIGNARD B BOSSARD AE COSTE C eta | 2000 | Anesthesiology2000，93，2： | 1 |
| 4 | Acute opioid tolerance :in- traoperativc remifentanil increases postoperative pain and morphine re- quirement显示文摘 | Guignard B Bossard AE Coste C | 2012 | Anesthesiology2012，939，2： | 1 |
| 5 | Acute opioid tolerance: in- traoperative remifentanil increases postoperative pain and morphine requirement 显示文摘 | Guignard B Bossard AE Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 6 | Ten- year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy 显示文摘 | Hennequin C Bossard N Servagi-Vernat S | 2013 | Int J Ra- diat Oncol Biol Phys2013，86，5： | 1 |
| 7 | Forced fluid removal in critically ill patients with acute kidney injury显示文摘 | Ganter C C Hochuli R Bossard M | 2012 | Acta Anaesthesiol Scan d2012，56，9： | 1 |
| 8 | Aute opioid tolerance:intraoperative remifentanil increases postoperative pain and morphine requirement显示文摘 | Guignard B bossard AE Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 9 | Real-time RT-PCR:a complementary method to detect Her-2 status in breast carcinoma显示文摘 | Bossard C Bieche I Le Doussal V | 2005 | Anticancer Res2005，，25： | 1 |
| 10 | Acute opioid tolerance:intraoperative remifentanil increases postoperative pain and morphine requirement显示文摘 | Guignard B Bossard A Coste C | 2000 | Anesthesiol2000，93，2： | 1 |
| 11 | Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis显示文摘 | Bossard C Deni SMG Bezieaus S | 2007 | Oncol Rep2007，18，5： | 1 |
| 12 | MRI and CT in a case of pituitary adscess显示文摘 | Himed A Badet C | 1992 | J Neuroradiol1992，，： | 1 |
| 13 | Acute opioid tolerance: tntraoperative remifentanil increases postoperative pain and morphine requirement 显示文摘 | Guignard B Bossard A E Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 14 | Acute opioid tolerance:' intraoperative remifentanil increases postoperative pain and morphine requirement 显示文摘 | Guignard B Bossard AE Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 15 | Acute opioid tolerance: intraoperative remit-entanil increases postoperative pain and morphine requirement显示文摘 | Guignard B Bossard AE Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 16 | Acute opioid tolerance;intraoperative remifentanil increases postoperative pain and morphine requirement显示文摘 | Guignard B Bossard AE Coste C | 2000 | Anesthesiology2000，93，： | 1 |
| 17 | Acute opioid tolerance: intraoperative remffentanil increases postoperative pain and morphive requirement 显示文摘 | Guigard B Bossard AE Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 18 | Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor显示文摘 | FERECATU I BOROT M C BOSSARD C | 2010 | Particle and Fibre Toxicology2010，7，1： | 1 |
| 19 | Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement显示文摘 | Guignard B Bossard AE Coste C | 2000 | Anesthesiology2000，93，： | 1 |
| 20 | Why have green stems? 显示文摘 | BOSSARD C C REJMANEK M | 1992 | Funct Ecol1992，6，： | 1 |
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