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| 1 | Microbiota transplantation: concept, methodology and strategy for its modernization显示文摘烘便的 microbiota 移植(FMT ) 在最近的年里成为了 biomedicine 和临床的药的一个研究焦点。从为不同疾病的 FMT 的临床的反应为与各种各样的混乱联系的 microbiota 主人相互作用提供了证据,包括 Clostridium 顽固感染,煽动性的肠疾病,糖尿病 mellitus,癌症,肝肝硬化, gutbrain 疾病和其它。为了讨论使用微生物从古老的中国治疗人的疾病到电流的经验,时代应该在向前移动标准化 FMT 并且完成更好的未来是重要的。这里,我们基于文学和州的专家观点从 FMT 考察 microbiota 移植的变化概念到选择 microbiota 移植, FMT 的方法论发展和 stepup FMT 策略。 | Faming Zhang Bota Cui Xingxiang He Yuqiang Nie Kaichun Wu Daiming Fan | 2018 | Protein & Cell2018，9，5： | 79 |
| 2 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 3 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 4 | Fecal microbiota transplantation is an effective rescue therapy for refractory inflammatory bowel disease显示文摘 | Bota Cui Pan Li Lijuan Xu Zhaoyuan Peng Youquan Zhao Huiquan Wang Zhi He Ting Zhang Guozhong Ji Kaichun Wu Daiming Fan Faming Zhang | 2015 | Inflammation and Cell Signaling2015，，： | 1 |
| 5 | Washed microbiota transplantation improves the fertility of patients with inflammatory bowel disease显示文摘To the Editor:Female patients with inflammatory bowel disease(IBD)have lower fertility rates and take longer time to conceive than the healthy population.How to improve the fertility in patients with IBD is a critical challenge. | Zhaoyang Zhao Xinghui Ji Ting Zhang Qianqian Li Cicilia Marcella Quan Wen Bota Cui Faming Zhang | 2022 | Chinese Medical Journal2022，，12： | 0 |
| 6 | Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis:The first case report and narrative review显示文摘Amyotrophic lateral sclerosis(ALS) is known as a progressive paralysis disorder characterized by degeneration of upper and lower motor neurons, and has an average survival time of three to five years. Growing evidence has suggested a bidirectional link between gut microbiota and neurodegeneration. Here we aimed to report one female case with ALS, who benefited from washed microbiota transplantation(WMT), an improved fecal microbiota transplantation(FMT), through a transendoscopic enteral tube during a 12-month follow-up. Notedly, the accidental scalp trauma the patient suffered later was treated with prescribed antibiotics that caused ALS deterioration. The subsequent rescue WMTs successfully stopped the progression of the disease with a quick improvement. The plateaus and reversals occurred during the whole course of WMT. The stool and blood samples from the first WMT to the last were collected for dynamic microbial and metabolomic analysis. We observed the microbial and metabolomic changing trend consistent with the disease status. This case report for the first time shows the direct clinical evidence on using WMT for treating ALS, indicating that WMT may be the novel treatment strategy for controlling this so-called incurable disease. | Gaochen Lu Quan Wen Bota Cui Qianqian Li Faming Zhang | 2023 | The Journal of Biomedical Research2023，37，1： | 0 |
| 7 | Radiation injury and gut microbiota-based treatment显示文摘The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury(RI).RI is a common disease involving multiple human body parts and organs,yet effective treatments are currently limited.Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI.This article summarizes 10 common types of RI and their possible mechanisms.It also highlights the changes and potential microbiota-based treatments for RI,including probiotics,metabolites,and microbiota transplantation.Additionally,a 5P-Framework is proposed to provide a comprehensive strategy for managing RI. | Weihong Wang Bota Cui Yongzhan Nie Lijuan Sun Faming Zhang | 2024 | Protein & Cell2024，15，2： | 0 |
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