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| 1 | 初级医疗机构中协同护理对阿尔茨海默病老年患者的疗效观察:一项随机对照试验显示文摘Context: Most older adults with dementia will be cared for by primary care physicians, but the primary care practice environment presents important challenges to providing quality care. Objective: To test the effectiveness of a collaborative care model to improve the quality of care for patients with Alzheimer disease. Design, Setting, and Patients: Controlled clinical trial of 153 older adults with Alzheimer disease and their caregivers who were randomized by physician to receive collaborative care management (n=84) or augmented usual care (n=69)-at primary care practices within 2 US university-affiliated health care systems from January 2002 through August 2004. Eligible patients (identified via screening or medical record) met diagnostic criteria for Alzheimer disease and had a self-identified caregiver. Intervention: Intervention patients received 1 year of care management by an interdisciplinary team led by an advanced practice nurse working with the patient’s family caregiver and integrated within primary care. The team used standard protocols to initiate treatment and identify, monitor, and treat behavioral and psychological symptoms of dementia, stressing nonpharmacological management. Main Outcome Measures: Neuropsychiatric Inventory (NPI)-administered at baseline and at 6, 12, and 18 months. Secondary outcomes included the Cornell Scale for Depression in Dementia (CSDD), cognition, activities of daily living, resource use, and caregiver’s depression severity. Results: Initiated by caregivers’reports, 89%of intervention patients triggered at least 1 protocol for behavioral and psychological symptoms of dementia with a mean of 4 per patient from a total of 8 possible protocols. Intervention patients were more likely to receive cholinesterase inhibitors (79.8%vs 55.1%; P=.002) and antidepressants (45.2%vs 27.5%; P= .03). Intervention patients had significantly fewer behavioral and psychological symptoms of dementia as measured by the total NPI score at 12 months (mean difference, -5.6; P= .01) and at 18 months (mean difference, -5.4; P=.01). Intervention caregivers also reported significant improvements in distress as measured by the caregiver NPI at 12 months; at 18 months, caregivers showed improvement in depression as measured by the Patient Health Questionnaire-9. No group differences were found on the CSDD, cognition, activities of daily living, or on rates of hospitalization, nursing home placement, or death. Conclusions: Collaborative care for the treatment of Alzheimer disease resulted in significant improvement in the quality of care and in behavioral and psychological symptoms of dementia among primary care patients and their caregivers. These improvements were achieved without significantly increasing the use of antipsychotics or sedative-hypnotics. Trial Registration: clinicaltrials.gov Identifier: NCT00246896. | Callahan C. M. Boustani M. A. Unverzagt F. W. 周永(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 3 |
| 2 | Efficacy of me-mantine on behavioral and psychological symptoms related to dementia:a systematic meta-analysis显示文摘 | MAIDMENT I D FOX C G BOUSTANI M | 2008 | Ann Pharmacother2008，42，1： | 1 |
| 3 | A Preliminary Investigation Into Pre - and Post - purchase Risk Perception and Reduction显示文摘 | Mitchell V W Boustani Pail | 1994 | European Journal of Marketing1994，28，1： | 1 |
| 4 | Differential roles of STIM1 ,STIM2 and Orail in the control of cell proliferation and SOCE amplitude in HEK293 cells 显示文摘 | El Boustany C Katsogiannou M Delcourt P | 2010 | Cell Calcium2010，47，4： | 1 |
| 5 | The effect of demographicvariables on measuring perceived risk显示文摘 | MITCHELL V BOUSTANI P | 1993 | DevelopMarket Sci1993，26，： | 1 |
| 6 | Search for the Largest Two-dimensional Aggregates of Boron:An ab Initio Study显示文摘 | Boustani I B Zhu Z Tomanek D | 2011 | Phys Rev B2011，83，19： | 1 |
| 7 | Pharmacologicalmanagement of delirium in hospitalized adults systematic evidencereview 显示文摘 | Campbell N Boustani M A Ayub A | 2009 | J Gen Intern Med2009，27，7： | 1 |
| 8 | The role of diffusion and convective dispersion in vapour extraction process显示文摘 | BOUSTANI A MAINI B | 2001 | Journal of Canadian Petroleum Technology2001，40，4： | 1 |
| 9 | Capacitative calcium en- try and transient receptor potential canonical 6 expression control human hepatoma cell proliferation 显示文摘 | E1 Boustany C Bidaux G Enfissi A | 2008 | Hepatology2008，47，6： | 1 |
| 10 | The role of diffusion and con-vective dispersion in vapour extraction process显示文摘 | BOUSTANI A MAINI B | 2001 | Jour-nal of Canadian Petroleum Technology2001，40，1： | 1 |
| 11 | Ultrastructural Findings in Skin from Patients with Niemann-Pick Disease,Type C显示文摘 | BOUSTANY RN KAYE E ALROY J | 1990 | Pediatr Neurol(S0340-2096)1990，6，： | 1 |
| 12 | A preliminary investigation into pre-and post-purchase risk perception显示文摘 | Mitchell V Boustani P | 1994 | European Journal of Marketing1994，28，1： | 1 |
| 13 | A review of studies describing the use of acetyl cholinesterase inhibitors in Parkinson's disease dementia 显示文摘 | Maidment ID Fox C Boustani M | 2005 | Acta Psychiatr Scand2005，111，6： | 1 |
| 14 | Neutronic design investigation of a liquid injection-based second shutdown system for a typical research reactor using MCNPX显示文摘Safety systems, built on state-of-the-art technology, are essential for achieving acceptable levels of plant safety to minimize hazards to the reactor and the general public. The second shutdown system(SSS) as an engineered safety feature and a part of the reactor protection system(RPS) is a means for rapidly shutting down a nuclear reactor, keeping it in a subcritical state and serving as a backup to the first shutdown system(FSS). In this research, one SSS with two types of optimum chamber designs is proposed that take into account the main current characteristic features of the Tehran research reactor with improvements over earlier designs. They are based on a liquid neutron absorber injection that is preferably different, diverse, and independent from the FSS based on the rod drop mechanism. The major design characteristics of this SSS with two different chambers were investigated using MCNPX 2.6.0 code. The performed calculations showed that the designed SSS is a reliable shutdown system, assuring an appropriate shutdown margin and injection time, with no significant effects on the effective delayed neutron fraction while causing minimal variations to the core structure. Further, the reasonable financial cost and the prolongation of the operation cycle are additional advantages of this design. | Ehsan Boustani Mostafa Hassanzadeh | 2018 | Nuclear Science and Techniques2018，29，3： | 1 |
| 15 | Activation of the systemic and adipose renin angiotensin system in rats with diet-induced obesity and hypertension 显示文摘 | Boustany CM Bharadwaj K Dauherty A | 2004 | Am J Physiol Regul Integr Comp Physiol2004，287，4： | 1 |
| 16 | Hahitat and behaviour of yellowfin tuna Thunnus albacares in the Gulf of Mexico determined using pop-up satellite archival tags显示文摘 | Weng K C Stokesbury M J W Boustany A M | 2009 | Journal of Fish t~ology2009，74，7： | 1 |
| 17 | Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation 显示文摘 | Boustany C Bidaux G Enfissi A etal | 2008 | Hepatology2008，47，6： | 1 |
| 18 | Novel expression of ACE2 in adi-pose tissue and regulation by PPAR ligands and by high fat diets显示文摘 | Boustany C Cassis L Kentucky UO | 2006 | Hypertension2006，48，4： | 1 |
| 19 | Cell wall bound phenofic acid and lignin contents in date palm as related to its resistance to Fusarium oxysporum 显示文摘 | Modafar C E L Boustani E E L | 2001 | Biologia plantarum2001，44，1： | 1 |
| 20 | The cognitive impact of anticholinergics s a clinical review 显示文摘 | Campbell N Boustani M Limbil T | 2009 | Clin Interv Aging2009，4，： | 1 |
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