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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression. | Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 3 | Pharma cokinetics of enrofloxacin in fingerling rainbow trout Concorhynchus mykiss显示文摘 | WOOSTER G A ST LEGERJ | 1992 | J Vet Pharmacol Therap1992，，15： | 1 |
| 4 | The influence of recent life experience on the health of college freshmen显示文摘 | Marx M B Garring T F Bowers F R | 1975 | Journal of psychosomatic research1975，，19： | 1 |
| 5 | Disease and community structure : the importance of host- regulation in a host-host-pathogen model 显示文摘 | BEGON M BOWERS R G KADIANAKIS N | 1992 | Am Nat1992，139，： | 1 |
| 6 | Platinum silicide fusion bonding显示文摘 | ISMAIL M S BOWER R W | 1991 | Electronics Letters1991，27，13： | 1 |
| 7 | Diseases of cultured Japanese scallops (Patinopecten yessoensis ) in British Columbia, Canada 显示文摘 | Bower S M Blackbourn J Meyer G R | 1992 | Aquaculture1992，107，： | 1 |
| 8 | Cephalopod paralarvae assemblages in Hawaiian Islands waters 显示文摘 | BOWER J R PSEKI M YOUNG R E | 1999 | Marine Ecology Progress Series1999，185，2： | 1 |
| 9 | Foamedasphalt Paving Mixtures:Preparation of Design Mixes and Treatment of Test Specimens显示文摘 | Ruckel PJ Acott S M Bowering R H | 1983 | Transportation Research Record1983，911，： | 1 |
| 10 | Modeling sucrose hydrolysis in dilute sulfuric acid solutions at pretreatment conditions for lignocellulosic biomass显示文摘 | Bower S Wickramasinghe R Nagle N J | 2008 | Bioresource Technology2008，99，15： | 1 |
| 11 | The first experimental observation of stable H4+ ions显示文摘 | Kirchner N J Gilbert J R Bowers M T | | 0，，1： | 1 |
| 12 | A model of disease and vaecination for infections with acute and chronic phasea 显示文摘 | Reade B Bowers R Begon M | 1998 | Theoretical Biology1998，190，： | 1 |
| 13 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 14 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 15 | Strain specificity of soybean mosaic vi- rus seed transmission in soybean 显示文摘 | Bowers G R Goodman R M | 1991 | Crop Science1991，31，5： | 1 |
| 16 | Neutronreflectivity studies at liquid-liquid interfaces:Methodology and analysis显示文摘 | Ali Zarbakhsh Webster R P | 2001 | Langmuir2001，，17： | 1 |
| 17 | The sorghum bicolor genome and the diversification of grasses 显示文摘 | Paterson A H Bowers J E Bmggmann R | 2009 | Nature2009，457，： | 1 |
| 18 | Cloning,sequencing,and characterization of the Bacillus subtilis biotin biosynthetic operon显示文摘 | Bower S Perkins J B Yocum R R | 1996 | Journal of Bacteriology1996，178，： | 1 |
| 19 | The determination of hemodialysis blood recirculation using blood urea nitrogen measurements 显示文摘 | Hester R L Curry E Bower J | 1992 | Am J Kidney D s1992，20，： | 1 |
| 20 | Reflection of radiant energy from soils 显示文摘 | Bowers S A Hunks R J | 1965 | Soil Science1965，100，2： | 1 |
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