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| 1 | 地下水铀污染的原位微生物还原与固定:在美国能源部田纳西橡树岭放射物污染现场的试验显示文摘总结了美国斯坦福大学和橡树岭国家实验室等在美国能源部田纳西州橡树岭综合试验基地进行的铀污染原位微生物修复阶段性试验结果.本试验利用微生物以乙醇为电子供体还原地下水和沉积物中的六价铀为不溶解的四价铀,使之原位固定化.随后通过加入溶解氧和硝酸盐来试验微生物还原后的地下水层中还原固定态铀的稳定性.通过预处理和长期间隔注入乙醇溶液,地下水中铀浓度从40~60mg·L-1降至0.03mg·L-1以下,达到了美国环保署饮用水的标准.还原的四价铀主要以U(Ⅳ)-Fe复合物的形态存在.结果表明,固定化后的四价铀只有在厌氧条件下才是稳定的,溶解氧和硝酸盐侵入地下水层后会使固定化的四价铀重新氧化为溶解态的六价铀.在试验过程中,采用多种分子生物学方法检测了微生物种群的变化和与铀氧化还原反应有关的功能微生物.本研究表明,在维持试验系统无氧和无硝酸盐的条件下,通过添加乙醇为电子供体可有效地促进地下水中土著功能微生物的活性,从而实现铀的原位还原固定与稳定. | 吴唯民 Jack Carley David Watson 顾宝华 Scott Brooks Shelly D.Kelly Kenneth Kemner Joy D.van Nostrand 吴力游 许玫英 周集中 罗剑 Erick Cardenas 黄家琪 Matthew W.Fields Terence L.Marsh James M.Tiedje Stefan J.Green Joel E.Kostka Peter K.Kitanidis Philip M.Jardme CraigS.Criddle | 2011 | 环境科学学报2011，31，3： | 28 |
| 2 | Development and application of functional gene arrays for microbial community analysis显示文摘功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示,简单、人工的微生物引起的社区,改编如此的一种技术分析复杂微生物引起的社区仍然以设计,样品准备,和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGA ) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGA 有关明确地给问题调音,例如 oligonucleotide 探查设计, nucleic 酸抽取和纯化,数据分析,特性,敏感,和量的能力详细被讨论。最近的研究证明了 FGA 能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析,并且连接微生物引起的结构到生态系统工作。 | Z. L. HE J. D. VAN NOSTRAND L.Y. WU J. Z. ZHOU | 2008 | 中国有色金属学会会刊:英文版2008，18，6： | 21 |
| 3 | Development and applications of functional gene microarrays in the analysis of the functional diversity,composition,and structure of microbial communities显示文摘Functional gene arrays(FGAs)are a special type of microarrays containing probes for key genes involved in microbial functional processes,such as biogeochemical cycling of carbon,nitrogen,sulfur,phosphorus,and metals,biodegradation of environmental contaminants,energy processing,and stress responses.GeoChips are considered as the most comprehensive FGAs.Experimentally established probe design criteria and a computational pipeline integrating sequence retrieval,probe design and verification,array construction,data analysis,and automatic update are used to develop the GeoChip technology.GeoChip has been systematically evaluated and demonstrated to be a powerful tool for rapid,specific,sensitive,and quantitative analysis of microbial communities in a high-throughput manner.Several generations of GeoChip have been developed and applied to investigate the functional diversity,composition,structure,function,and dynamics of a variety of microbial communities from different habitats,such as water,soil,marine,bioreactor,human microbiome,and extreme ecosystems.GeoChip is able to address fundamental questions related to global change,bioenergy,bioremediation,agricultural operation,land use,human health,environmental restoration,and ecological theories and to link the microbial community structure to environmental factors and ecosystem functioning. | Zhili HE Joy DVAN NOSTRAND Ye DENG Jizhong ZHOU | 2011 | Frontiers of Environmental Science & Engineering2011，5，1： | 9 |
| 4 | Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. | Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 8 |
| 5 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 6 | The benefits and risks of I-131 therapy in patients with well-differentiated thyroid cancer 显示文摘 | VAN NOSTRAND D | 2009 | Thyroid2009，19，12： | 1 |
| 7 | Amyloid reduction by amyloid-β vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models ofAIzheimer's disease显示文摘 | Wilcock D Gharkholonarehe N Van Nostrand W | | 0，，25： | 1 |
| 8 | Primary lung chorioearcinoma masquerading as a metastatic gestational neoplasm 显示文摘 | Van Nostrand KM Lucci JA Liao SY | 1994 | Gynecol Oncol1994，53，3： | 1 |
| 9 | The protective effect of astrocyte-derived 14, 15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture 显示文摘 | Terashvili M Sarkar P Nostrand M | 2012 | Neuroscience2012，223，20： | 1 |
| 10 | General and specific functions of exonic splicing silencers in splicing control显示文摘 | Wang Z Xiao X Van Nostrand E | | 0，，： | 1 |
| 11 | Functional gene diversity of soil microbial communities from five oil-contaminated fields in China显示文摘 | Liang Y Van Nostrand JD Deng Y | 2010 | The ISME Journal2010，5，： | 1 |
| 12 | Effective Reduction of Brown Fat FDG Uptake by Controlling Environmental Temperature Prior to PET Scan: an Expanded Case Series显示文摘 | Carlos Garcia Varalakshmi Bandaru Douglas Nostrand Shyam Chennupati Frank Atkins Elmo Acio Kanchan Kulkarni Massoud Majd | 2010 | Molecular Imaging and Biology2010，，6： | 1 |
| 13 | Primary lung choriocarcinoma masquerading as a metastatic gestational neoplasm显示文摘 | Van Nostrand K M Lucci J A 3rd Liao S Y | 1994 | Gynecol Oncol1994，53，： | 1 |
| 14 | Huanglongbing alters the structure and functional diversity of microbial communities associated with citrus rhizosphere显示文摘 | Trivedi P He ZL van Nostrand J D | 2012 | International Society for Microbial Ecology2012，6，2： | 1 |
| 15 | Microbial gene functions enriched in the Deepwater Horizon deep-sea oil plume显示文摘 | Lu Z Deng Y Van Nostrand J D | 2011 | The ISME journal2011，6，2： | 1 |
| 16 | Microarray-based analysis of microbial functional diversity along an oil contamination gradient in oil field显示文摘 | Liang Y Li G Van Nostrand JD | 2009 | FEMS Microbiology Ecology2009，70，2： | 1 |
| 17 | Super bone scan 显示文摘 | Manier SM Van Nostrand D | 1984 | Semin Nucl Med1984，14，1： | 1 |
| 18 | Myoepithelioma-new concepts of histology and classification:a light and electron microscopic study显示文摘 | Dardick I Thomas MJ Van Nostrand AW | 1989 | Ultrastruct Pathol1989，13，： | 1 |
| 19 | Authentic Texts- Cultural Authenticity: An Editorial显示文摘 | Nostrand H L | 1982 | Modern Language Journal1982，73，1： | 1 |
| 20 | Epitaxial overgrowth of GaN nanocolumns显示文摘 | Averett K L Van Nostrand J E Albrecht J D | 2007 | J Vac Sci Technol B2007，25，： | 1 |
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