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| 1 | On the cell biology of pit cells,the liver-specific NK cells显示文摘INTRODUCTION Natural killer (NK) cells are functionally defined by their ability to kill certain tumor cells and virus-infected cells without prior | Luo DZ Vermijlen D Ahishali B Triantis V Plakoutsi G Braet F Vanderkerken K Wisse E | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 2 | Structural and functional aspects of the liver and liver sinusoidal cells in relation to colon carcinoma metastasis显示文摘Nowadays, liver metastasis remains difficult to cure. When tumor cells escape and arrive in the liver sinusoids, they encounter the local defense mechanism specific to the liver. The sinusoidal cells have been widely described in physiologic conditions and in relation to metastasis during the past 30 years. This paper provides an 'overview' of how these cells function in health and in diseases such as liver metastasis. | Katrien Vekemans Filip Braet | 2005 | World Journal of Gastroenterology2005，11，33： | 4 |
| 3 | The hepatic sinusoidal endothelial lining and colorectal liver metastases显示文摘Colorectal cancer (CRC) is a common malignant disease and the severe nature of cases in men and women who develop colorectal cancer makes this an important socio-economic health issue. Major challenges such as understanding and modeling colorectal cancer pathways rely on our understanding of simple models such as outlined in this paper. We discuss that the development of novel standardized approaches of multidimensional (correlative) biomolecular microscopy methods facilitates the collection of (sub) cellular tissue information in the early onset of colorectal liver metastasis and that this approach will be crucial in designing new effective strategies for CRC treatment. The application of X-ray micro-computed tomography and its potential in correlative imaging of the liver vasculature will be discussed. | Filip Braet Keissuke Nagatsuma Masaya Saito Lilian Soon Eddie Wisse Tomokazu Matsuura | 2007 | World Journal of Gastroenterology2007，13，6： | 3 |
| 4 | Multifaceted nature of membrane microdomains in colorectal cancer显示文摘Membrane microdomains or lipid rafts are known to be highly dynamic and to act as selective signal transduction mediators that facilitate interactions between the cell's external and internal environments.Lipid rafts play an important mediating role in the biology of cancer:they have been found in almost all existing experimental cancer models,including colorectal cancer (CRC),and play key regulatory roles in cell migration,metastasis,cell survival and tumor progression.This paper explores the current state of knowledge in this field by highlighting some of the pioneering and recent lipid raft studies performed on different CRC cell lines and human tissue samples.From this literature review,it becomes clear that membrane microdomains appear to be implicated in all key intracellular signaling pathways for lipid metabolism,drug resistance,cell adhesion,cell death,cell proliferation and many other processes in CRC.All signal transduction pathways seem to originate directly from those peculiar lipid islands,thereby orchestrating the colon cancer cells' state and fate.As confirmed by recent animal and preclinical studies in different CRC models,continuing to unravel the structure and function of lipid rafts-including their associated complex signaling pathways-will likely bring us one step closer to better monitoring and treating of colon cancer patients. | Kristina A Jahn Filip Braet | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 5 | Reconstruction of liver organoid using a bioreactor显示文摘瞄准:用一个简历人工的肝为肝机关在试管内的重建开发有效技术。方法:我们以前报导一个光线流动的生物反应器(RFB ) 能提供一个三维的高密度的文化系统。我们目前重建了和老鼠把一根功能的人的肝细胞癌房间线(FLC-5 ) 用作 hepatocytes 的肝或硬鳞鱼使房间(秒) 线 M1 和老鼠使不朽的正弦曲线内皮不朽肝的星形的房间(HSC ) 在 RFB 作为非实质的的房间衬里 A7。二 x 10 (7 ) FLC-5 房间在 RFB 被孵化。在 5 d 以后, 2 x 10 (7 ) A7 房间以 10 的另一增加(7 ) 跟随的一种类似的方式被增加 M1 房间 5 d 以后。在三天灌注以后,有支持者房间的一些纤维素祷告被收获。最后潜伏期与支持者房间一起为 2 h 然后留下的纤维素祷告与 200 nmol/L swinholide A 包括了灌注从 RFB 被收获。房间形态学被传播电子显微镜学(TEM ) 和扫描电子显微镜学(SEM ) 观察。估计 hepatocyte 功能,我们在 RFB 单个类型的文化和 cocultures 与那些相比在单层文化由 FLC-5 为脲周期酶以及白朊合成比较了 mRNA 表示。结果:由传播电子显微镜学, FLC-5, M1,和 A7 在一个像肝的组织在与灌注方面的关系被安排。类似于胆汁 canaliculi 的结构在 FCL-5 房间之间被看见。扫描电子显微镜学在秒表面上表明了窗。当我们介绍了肌动朊绑定代理人 swinholide 时, vesiculo-vacuolar 细胞器(VVO ) 和窗的数字增加了 -- 在为 2h 的 RFB 的 A。关于肝功能,脲在编码 arginosuccinate 合成酶的 mRNAs 的媒介,和表达式被发现,当三种房间类型是在 RFB 的 cocultured 时,精氨酸酶增加了。然而,白朊合成减少了。结论:在 RFB 系统罐头的合作文化戏剧性地改变所有房间类型的结构和功能,包括 hepatocytes 的功能的特征。我们的系统用一个简历人工的肝为一个肝或硬鳞鱼的重建证明有效。 | Masaya Saito Tomokazu Matsuura Takahiro Masaki Tetsuro Suzuki Haruka Maehashi Keiko Shimizu Yoshiaki Hataba Tohru Iwahori Filip Braet | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 6 | Follow-up results of different treatment programs for obese children显示文摘 | Braet C Winckel MV Leeuwen KV | 1997 | Acta paediatr1997，86，： | 1 |
| 7 | Hydrodynamics based transfection in normal and fibrotic rats显示文摘AIM: Hydrodynamics based transfection (HBT), the injection of a large volume of naked plasmid DNA in a short time is a relatively simple, efficient and safe method for in vivo transfection of liver cells. Though used for quite some time, the mechanism of gene transfection has not yet been elucidated. METHODS: A luciferase encoding plasmid was injected using the hydrodynamics based procedure into normal and thioacetamide-induced fibrotic Sprague Dawley rats. Scanning and transmission electron microscopy images were taken. The consequence of a dual injection of Ringer solution and luciferase pDNA was followed. Halofuginone, an anti collagen type I inhibitor was used to reduce ECM load in fibrotic rats prior to the hydrodynamic injection. RESULTS: Large endothelial gaps formed as soon as 10’ following hydrodynamic injection; these gradually returned to normal 10 d post injection. Hydrodynamic administration of Ringer 10 or 30 m prior to moderate injection of plasmid did not result in efficient transfection suggesting that endothelial gaps by themselves are not sufficient for gene expression. Gene transfection following hydrodynamic injection in thioacetamide induced fibrotic rats was diminished coinciding with the level of fibrosis. Halofuginone, a specific collagen typeⅠ inhibitor, alleviated this effect. CONCLUSION: The hydrodynamic pressure formedfollowing HBT results in the formation of large endothelial gaps. These gaps, though important in the transfer of DNA molecules from the blood to the space of Disse are not enough to provide the appropriate conditions for hepatocyte transfection. Hydrodynamics based injection is applicable in fibrotic rats provided that ECM load is reduced. | Rita Yeikilis Shunit Gal Natalia Kopeiko Melia Paizi Mark Pines Filip Braet Gadi Spira | 2006 | World Journal of Gastroenterology2006，12，38： | 1 |
| 8 | Dioxin pollution and endometriosis in Belgium显示文摘 | Braet P Kennedy SH | 1994 | Hum Reprod1994，9，6： | 1 |
| 9 | fMRI activation during response inhibition and error processing:The role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD显示文摘 | Braet W Johnson K A Tobin C T | 2011 | Neuropsychologia2011，，： | 1 |
| 10 | A Comparative atomic force microscopy study on living skin fibroblasts and liver endothelial cells 显示文摘 | Braet F de Zanger R Seynaeve C | 2001 | Electron Microsc2001，50，4： | 1 |
| 11 | Connexin channels, connexin mimetic peptides and ATP release 显示文摘 | Leybaert L Braet K Vandamme W | 2003 | Cell Commun Adhes2003，10，46： | 1 |
| 12 | AFM imaging and elasticity measurement s on living rat liver macrophages 显示文摘 | Rotsch C Braet F Wisse E | 1997 | Cell Biol Int1997，21，11： | 1 |
| 13 | Insulin-like growth factor-I acts as a chemoattractant factor for 5T2 multiple myeloma cells显示文摘 | Vanderkerken K Asosingh K Braet F | 1999 | Blood1999，93，1： | 1 |
| 14 | A comparative atomic force m icros copy study on living skin fibroblasts and liver endothelial cells 显示文摘 | Braet F de Zanger R Seynaeve C | 2001 | J Elec tron Microsc2001，50，4： | 1 |
| 15 | comparative scanning ,transmission and atomic force microscopy of the microtubular cytoskeleton in fenestrated liver endothelial cells 显示文摘 | Braet F Zanger DR Kalle W | 1996 | Scanning Microsc Suppl1996，10，： | 1 |
| 16 | FMRI activation during response inhibition and error processing:the role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD显示文摘 | Braet W Johnson KA Tobin CT | 2011 | Neuropsychologia2011，49，7： | 1 |
| 17 | The cognitive behavioural model for eating disorders: a direct evaluation in children and adolescents with obesity 显示文摘 | Deealuwe V Braet C | 2005 | Eat Behav2005，6，3： | 1 |
| 18 | VEGF2-induced mobiliztion of eaveolae and increase in permeability of endothelial cells显示文摘 | Chen J Braet F Brodsky S | 2002 | Am J Physiol Cell Physiol2002，282，5： | 1 |
| 19 | Assessment of a method of isolation, purification, and cultivation of rat liver sinusoidal endothelial cells显示文摘 | Braet F De Zanger R Sasaoki T | 1994 | Lab Invest1994，70，6： | 1 |
| 20 | The Due Diligence Process-Guiding Principles for Early Stage Innovative Products and Venture Capital Investments显示文摘 | BRAET J | 2007 | The Journal of Private Equity2007，10，3： | 1 |
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