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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 3 | Re-Os isotopic systematics of primitive lavas from the Lassen region of the Cascade Arc,California显示文摘 | Brandon A D Clynne M A | 2000 | Earth and Planetary Science Letters2000，177，34： | 1 |
| 4 | Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment显示文摘 | BRANDON E F A OOMEN A G ROMPELBERG C J M | 2006 | Regulatory Toxicology and Pharmacology2006，44，： | 1 |
| 5 | Potential benefits of communication in transitive memory system 显示文摘 | HULLINSHEAD A B BRANDON D P | 2003 | Human Communication Research2003，29，： | 1 |
| 6 | Osmium recycling in subduction zones显示文摘 | Creaser R A Shirey S B | 1996 | Science1996，272，： | 1 |
| 7 | Properties of bulk polycrystalline CVD diamond显示文摘 | Sussmann R S Brandon J R Scarsbrook G A | 1994 | Diamond and Related Materials1994，，3： | 1 |
| 8 | Optimizing the level of renewable electric R&D expenditures using real options a- nalysis 显示文摘 | Graham A Davis Brandon Owens | 2003 | Energy Policy2003，31，15： | 1 |
| 9 | 186Os-187Os systematics of Gorgona Island komatiites:implications for early growth of the inner core显示文摘 | Walker R J Puchtel I S | 2003 | Earth and Planetary Science Letters2003，206，34： | 1 |
| 10 | The effect of root pruning on the maturation of loblolly pine (Pinus taeda) plantlets, rooted hypocotyls, and seedlings显示文摘 | Wisniewski L A Brandon D L McKeand S E | 1991 | Canadian Journal of Forest Research1991，21，7： | 1 |
| 11 | Consumer product in vitro digestion model : Bioaccessibility of contaminants and its application in risk assessment 显示文摘 | BRANDON E F OOMEN A G ROMPELBERG C J | 2006 | Regul Toxicol Pharmacol2006，44，2： | 1 |
| 12 | Com- bining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer ceils via suppression of sur- vival signaling 显示文摘 | Saturno G Valenti M De Haven Brandon A | 2013 | Oncotarget2013，4，8： | 1 |
| 13 | Spartacas: automating component reuse and adaptation显示文摘 | BRANDON M PERRY A | 2004 | IEEE Trans on Software Engineering2004，30，9： | 1 |
| 14 | Antimalarial quinolines and artemisinin inhibit endocytosis in plasmodium falciparum显示文摘 | Heinrich C Donelly A Ursula M Sandra A Joanne E Brandon W | 2004 | Antimicro Agents Chemother2004，48，： | 1 |
| 15 | IcsA,a polarly localized autotransporter with an atypical signal peptide,uses the Sec apparatus for secretion,although the Sec apparatus is circumferentially distributed显示文摘 | Brandon LD Goehring N Janakiraman A | 2003 | Mol Microbiol2003，50，： | 1 |
| 16 | Delivery of the Cre recombinase by a self-deleting lentiviral vector:efficient gene targeting in vivo显示文摘 | Pfeifer A Brandon E P Kootstra N | 2001 | Proc Natl Acad Sci USA2001，98，11： | 1 |
| 17 | Linking neuredevelopmental and synaptic theories of mental illness through DISCI显示文摘 | Brandon NJ Sawa A | 2011 | Nat Rev Neurosci2011，12，12： | 1 |
| 18 | Osmium recycling in subduction zones显示文摘 | BRANDON A D CREASER R A SHIREY S B | 1996 | Science1996，272，： | 1 |
| 19 | Injectable silicone implants as vaccine delivery vehicles显示文摘 | S.A Lofthouse M Kajihara S Nagahara A Nash G.J Barcham B Sedgmen M.R Brandon A Sano | 2002 | Vaccine2002，，13： | 1 |
| 20 | Com- parison of plasticity in vivo and in vitro in the developing vi- sual cortex of normal and protein kinase A RI/3-deficient mice显示文摘 | HENSCH T K GORDON J A BRANDON E P | 1998 | The Journal of Neuroscience1998，18，6： | 1 |
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