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| 1 | 室内氡与肺癌关系研究显示文摘目的 直接调查居室水平氡浓度对居民肺癌危险度的影响 ,并与由矿工受照结果推导的结论相比较。方法 在甘肃省平凉、庆阳两地区进行病例 对照研究。该地区居民稳定而室内氡水平较高。肺癌病例必须是在 1994年 1月至 1998年 4月期间诊断 ,年龄在 30~ 75岁之间 ,居住在平凉和庆阳两地区的居民。根据人口调查资料随机选取对照 ,对照要在年龄、性别、地区方面与病例相匹配。在过去 5~ 30年期间 ,凡住过两年以上的房间都布放了氡探测器。氡测量涵盖了 77%的照射周期。结果 病例居室的平均氡浓度为 2 30 4Bq m3 (n =76 8) ,对照为 2 2 2 2Bq m3 (n =16 5 9)。居民肺癌危险度随室内氡水平的增高有所上升 (P <0 0 0 1)。根据线性模型 ,对全部研究个体而言 ,在 10 0Bq m3 情况下 ,附加比值比 (EOR)为 0 19(95 %CI:0 0 5 ,0 47)。对测量涵盖了 10 0 %照射周期的个体 ,为 0 31(95 %CI:0 10 ,0 81)。在对照射的不确定度进行调整后 ,估算值可增加70 %。结论 研究结果证明室内水平氡照射会增加肺癌危险度 。 | 王作元 Lubin JH 王陇德 张守志 Boice JD Jr 崔宏星 张淑蓉 Conrath SC 夏英 尚兵 Brenner A 雷苏文 Metayer KC 曹吉生 Chen KW 雷淑杰 Kleinerman RA | 2002 | 中华放射医学与防护杂志2002，22，3： | 28 |
| 2 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 3 | Sucrose synthase, starch accumulation, and tomato fruit sink strength显示文摘 | Wang F Sanz A Brenner ML | 1993 | Plant Physiology1993，101，： | 1 |
| 4 | Sex effects in evaluating leaders显示文摘 | D A Butterfield | 1989 | Journal of Applied Psychology1989，，6： | 1 |
| 5 | Nitric oxide:a key factor behind thedysfunctionality of endothelial progenitor cells in diabetes mellitus type-2显示文摘 | Hamed S Brenner B Roguin A | 2011 | Cardiovasc Res2011，91，1： | 1 |
| 6 | Diabetes and thyroid cancer risk in the National Institutes of Health-AARP Diet and Health Study显示文摘 | Aschebrook-Kilfoy B Sabra MM Brenner A | 2011 | Thyroid2011，21，： | 1 |
| 7 | Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21 st century 显示文摘 | Puhe D Gondos A Brenner H | 2009 | Blood2009，113，7： | 1 |
| 8 | Solar Forcing of Drought Frequency in the Maya Lowlands 显示文摘 | David A Hodell Mark Brenner Jason H Curtis | 2001 | SCIENCE2001，292，18： | 1 |
| 9 | Effect of alchol con- sumption on systemic markers of inflammation显示文摘 | Imhof A Froehlich M Brenner H | 2001 | Lancet2001，357，： | 1 |
| 10 | Influence of two different volume replacement regimens on renal function in elderly patients undergoing cardiac surgery: comparison of a new starch preparation with gelatin显示文摘 | Boldt J Brenner T Lehmann A | 2003 | Intensive Care Med2003，29，5： | 1 |
| 11 | BK channel 134 subunit reduces dentate gyrus excitability and protects a- gainst temporal lobe seizures显示文摘 | Brenner R Chen Q H Vilaythong A | 2005 | Nat Neurosei2005，8，12： | 1 |
| 12 | Vasoregulation by the betal subunit of the calcium-activated potassium channel显示文摘 | Brenner R Perez G J Bonev A D | 2000 | Nature2000，407，6806： | 1 |
| 13 | HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway 显示文摘 | Finzer P Krueger A Stohr M Brenner D Soto U Kuntzen C Krammer PH Rosl F | 2004 | Oncogene2004，23，28： | 1 |
| 14 | Heparanase induces tissue fac- tor expression in vascular endothelial and cancer ceils 显示文摘 | Nadir 'Y Brenner B Zetser A | 2006 | J Thromb Haemost2006，4，11： | 1 |
| 15 | Transnational Networking and Business Performance: Ethnic Entrepreneurs in Canada 显示文摘 | KARIV D MENZIES T V BRENNER G A | 2009 | Entrepreneur- ship and Regional Development2009，21，3： | 1 |
| 16 | The effect of clumping and stomatal response on evaporation from sparsely vegetated shrublands 显示文摘 | Brenner A J Incoll L D | 1997 | Agricultural and Forest Meteorology1997，84，34： | 1 |
| 17 | Mieropartieles and placental hemostasis 显示文摘 | Aharon A Brenner B | 2009 | Thromb Res2009，123，2： | 1 |
| 18 | Wide-Area Traffic Monitoring With the SAR/GMTI System PAMIR 显示文摘 | Cerutti-Maori D Klare J Brenner A R and Ender J H G | 2008 | IEEE Transactions on Geoscience and Remote Sensing2008，46，10： | 1 |
| 19 | RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocyte显示文摘 | Rot A Krieger M Brenner T | 1992 | J Exp Med1992，176，： | 1 |
| 20 | Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation显示文摘 | Brenner A J Stamplfer MR Aldaz CM | 1998 | Oncogene1998，17，2： | 1 |
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