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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Ovarian autoimmune disease: clinical concepts and anima models显示文摘卵巢不是一个 immunologically 给予优惠的机关,但是在为卵巢特定的抗原的 tolerogenic 机制的一个故障在生育力上有灾难性的后果在里面女人,和这在自体免疫的疾病的鼠科的模型被复制。孤立的卵巢的自体免疫的疾病在女人是稀罕的,由于疾病和无能到的严厉可能播送越过代授与卵巢的疾病的基因信息。尽管如此,自体免疫的卵巢炎经常与另外的自体免疫的疾病联合被观察,特别地自体免疫的肾的疾病,并且在社会和单个健康上拿使用费。在老鼠的研究揭示了保护卵巢免受自体免疫的攻击的伤害的至少二机制。这些机制为自体免疫的管理者(亚耳河) 由导出胸腺的规章的 T 房间,以及一个角色包括 autoreactive T 房间的控制,在髓的 thymic 导致限制织物的抗原的表示的一个 transcriptional 管理者上皮的房间在 T 房间的开发期间。尽管后者机制不完全地被定义,也的失败导致自体免疫调停指向和卵巢的滤泡的弄空,这很好被建立。在这评论,我们将探讨自体免疫调停的临床的特征和后果在女人的卵巢的不孕,以及由动物揭示了的疾病的可能的机制当模特儿。 | Bryce D Warren William K Kinsey Lynda K McGinnis Lane K Christenson Susmita Jasti Anne M Stevens Brian K Petroff Margaret G Petroff | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 4 | Uncoupling of cardiae cells by fatty acids structure activity relations hips显示文摘 | Burt J M Massey K D Brian N | 1991 | Am J Physiol1991，20，3： | 1 |
| 5 | The path forward for bio- fuels and biomaterials显示文摘 | Arthur J R Charlotte K W Brian H D | 2006 | Science2006，311，5760： | 1 |
| 6 | Tissue,preparation and fluorescence spectroscopy of bulk monoclinic显示文摘 | Williams D K Bihari B Brian M | 1998 | J Phys Chem B1998，102，6： | 1 |
| 7 | Adverse effects associated with physical restraint 显示文摘 | Wanda K Mohr Theodore A Petti Brian D Mohr | 2003 | Can J Psychiatry2003，48，5： | 1 |
| 8 | Applying PSQI: metrics and more 显示文摘 | Rahul K Lee D Brian N | 2011 | OtolaryngotHead Neck Surg2011，145，2： | 1 |
| 9 | Mass Spectroscopic Characterization of the Coronavirus Infectious Bronchitis Virus Nucleoprotein and Elucidation of the Role of Phosphorylation in RNA Binding by Using Surface Plasmon Resonance显示文摘 | Chen H Y Andrew G Brian K D | 2005 | J Virol2005，79，2： | 1 |
| 10 | The pathway forward for biofuels and biomaterials 显示文摘 | ARTHUR J R CHARLOTrE K W BRIAN H D | 2006 | Sci2006，311，： | 1 |
| 11 | The Synthesis and Characterization of Some Soluble Ruthenium and Osmium Clusters and a Preliminary Study of Their Use as Catalysts in the Water Gas Shift Reaction,Polyhedron 显示文摘 | Dare J F Paul J D Brian K N | 1998 | 17(1):28991998，17，1： | 1 |
| 12 | A brushless exciter model incorporating multiple rectifier modes and preisach's hysteresis theory显示文摘 | ALIPRANTIS D C SUDHOFF S D BRIAN T K | 2006 | IEEE Transactions on Energy Conversion2006，21，1： | 1 |
| 13 | The path forwards for biofuels and biomaterials显示文摘 | Arthur J R Charltte K W Brian H D | 2006 | Science2006，311，27： | 1 |
| 14 | Delineation and mod- elling of a nucleolar retention signal in the coronavirus nucleo- capsid protein 显示文摘 | Mark L R Brian K D Richard M J | 2006 | Traffic2006，7，： | 1 |
| 15 | Dysnatremias and Survival in Adult Burn Patients: A Retrospective Analysis显示文摘 | Stewart Ian J Morrow Benjamin D Tilley Molly A Snow Brian D Gisler Christopher Kramer Keith W Aden James K Renz Evan M Chung Kevin K | 2013 | American Journal of Nephrology2013，，1： | 1 |
| 16 | Tissue Preparation and Fluorescence Spectroscopy of Bulk Monoclinic显示文摘 | Williams D K Bihari B Brian M | 1998 | J Phys Chem B1998，102，6： | 1 |
| 17 | Influence of gas phase equilibria on the ehemieal vapor deposition of graphene显示文摘 | Amanda M L Brian D Ian A K | 2013 | ACS Nano2013，7，： | 1 |
| 18 | Prevalence of obesity and trends in the distribution of body mass index among US adults,1999-2010显示文摘 | KATHER INE M F MARGARET D C BRIAN K K | 2012 | JAMA2012，307，5： | 1 |
| 19 | The path forward for biofuels and biomaterials 显示文摘 | Arthur J R Charlotte K W Brian H D | 2006 | Science2006，311，： | 1 |
| 20 | Entrained-flow adsorption of mercury usiag activated carbon显示文摘 | Shannon D S Brian K G | 2001 | Air & Waste Manage2001，51，： | 1 |
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