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| 1 | Spontaneous fungal peritonitis: Micro-organisms, management and mortality in liver cirrhosis-A systematic review显示文摘BACKGROUND Spontaneous peritonitis is an infection of ascitic fluid without a known intraabdominal source of infection. spontaneous fungal peritonitis (SFP) is a potentially fatal complication of decompensated cirrhosis, defined as fungal infection of ascitic fluid in the presence of ascitic neutrophil count of greater than 250 cells/mL. AIM To determine the prevalence of fungal pathogens, management and outcomes (mortality) of SFP in critically ill cirrhotic patients. METHODS Studies were identified using PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Scopus databases until February 2019. Inclusion criteria included intervention trials and observation studies describing the association between SFP and cirrhosis. The primary outcome was in-hospital, 1-mo, and 6- mo mortality rates of SFP in cirrhotic patients. Secondary outcomes were fungal microorganisms identified and in hospital management by anti-fungal medications. The National Heart, Lung and Blood Institute quality assessment tools were used to assess internal validity and risk of bias for each included study. RESULTS Six observational studies were included in this systematic review. The overall quality of included studies was good. A meta-analysis of results could not be performed because of differences in reporting of outcomes and heterogeneity of the included studies. There were 82 patients with SFP described across all the included studies. Candida species, predominantly Candida albicans was the fungal pathogen in majority of the cases (48%-81.8%) followed by Candida krusei (15%- 25%) and Candida glabrata (6.66%-20%). Cryptococcus neoformans (53.3%) was the other major fungal pathogen. Antifungal therapy in SFP patients was utilized in 33.3% to 81.8% cases. The prevalence of in hospital mortality ranged from 33.3% to 100%, whereas 1-mo mortality ranged between 50% to 73.3%. CONCLUSION This systematic review suggests that SFP in end stage liver disease patient is associated with high mortality both in the hospital and at 1-mo, and that antifungal therapy is currently underutilized. | Tooba Tariq Furqan B Irfan Mehdi Farishta Brian Dykstra Eric Martin Sieloff Archita P Desai | 2019 | World Journal of Hepatology2019，11，7： | 7 |
| 2 | The safety of Voriconazole显示文摘 | Brian A P Jack B | 2002 | CID2002，35，10： | 1 |
| 3 | Low-temperature polyol synthesis of AuCuSn2 and AuCuSn2:using solution chemistry to access ternary intermetallic compounds as nanocrystals显示文摘 | Brian M L Nattamai S P B Raymond E S | 2005 | JACS2005，，： | 1 |
| 4 | Simultaneous inversion of pre-stack seismic data 显示文摘 | Hampson D P Brian H R Brad P B | 2005 | Expanded Abstracts of 75th Annual Internat SEG Mtg2005，，： | 1 |
| 5 | Modelling an infrared man portable air defence system显示文摘 | Birchenall R P Richardson M A Brian B | 2010 | Infrared Physics & Technology2010，53，5： | 1 |
| 6 | Does Perceived Organizational Support Mediate the Relationship between Procedural Justice and Behavior? 显示文摘 | Robert H M Gerald L B Brian P N | 1998 | Academy of Organizational Citizenship Management Journal1998，41，3： | 1 |
| 7 | Modifiable Factors Associated With Improved Cardiac Arrest Survival in a Multicenter Basic Life Support/Defibrillation System: OPALS Study Phase I Results显示文摘 | Ian G Stiell George A Wells Valerie J DeMaio Daniel W Spaite Brian J Field Douglas P Munkley Marion B Lyver Lorraine G Luinstra Roxanne Ward | 1999 | Annals of Emergency Medicine1999，，： | 1 |
| 8 | Urine biomarkers predict the cause of glomerular disease显示文摘 | SANJU A V BRIAN P MILOS N B | 2007 | J Am Soc Nephrol2007，18，： | 1 |
| 9 | Gene si- lencing using micro-RNA designed hairpins显示文摘 | Michael T M Christian P P Brian B H | 2002 | RNA2002，，8： | 1 |
| 10 | Light gap disturbance,recruitment limitation,and tree diversity in a neotropical forest显示文摘 | Hubbell S P Foster R B O'Brian S T Harms K E Condit R Wechsler B Wright S J Loo de Lao S | | 0，，： | 1 |
| 11 | Optical Properties of Tm^3+ Ions in Alkali Germanate Glass显示文摘 | Brian M W Norman P B Donald J R | 2006 | Journal of Non-Crystalline Solids2006，352，： | 1 |
| 12 | Effect of magnetic endoscope imaging on colonoscopy performance: a randomised controlled trial显示文摘 | Syed G Shah Jim C Brooker Christopher B Williams Catherine Thapar Brian P Saunders | 2000 | The Lancet2000，，9243： | 1 |
| 13 | A landscape effect in tenosynovial giant-cell tumor from activa- tion of CSF1 expression by a translocation in a minority of tumor cells 显示文摘 | Robert B West2 Brian P Rubin 2 Melinda A | 2006 | PNAS2006，103，： | 1 |
| 14 | Evaluation of ultraviolet light-emitting diodes for detection of atmospheric NO by photolysis-chemiluminescence显示文摘 | IIana B P Brian M L Thomas B R | 2010 | Journal of Atmospheric Chemistry2010，65，2： | 1 |
| 15 | Grey integer Programming显示文摘 | Huang Gouhe Brian W B Gilles G P | 1995 | European Journal of Operational Research1995，83，： | 1 |
| 16 | Review article:Comparative anatomy of the aldo-keto reductase superfa-mily显示文摘 | JOSEPH M J MILANIE J B BRIAN P C | 1997 | Biochem J1997，326，： | 1 |
| 17 | Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes显示文摘 | Sands Arthur T Zambrowicz Brian P Rosenstock Julio Lapuerta Pablo Bode Bruce W Garg Satish K Buse John B Banks Phillip Heptulla Rubina Rendell Marc Cefalu William T Strumph Paul | 2015 | Diabetes Care2015，，7： | 1 |
| 18 | Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia显示文摘 | Brian B Maryse P Richard C B | 2007 | J Physiol2007，580，2： | 1 |
| 19 | Measurement and analysis of dissolution patterns in rock fractures显示文摘 | Erik D P Brian B Yoseph Y | 2002 | Water Resources Research2002，38，2： | 1 |
| 20 | The ABCs of HVDC transmission technologies显示文摘 | Michael P B Brian K J | 2007 | IEEEPower&Energy2007，5，2： | 1 |
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