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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | Paediatric and adult colonic manometry: A tool to help unravel the pathophysiology of constipation显示文摘Colonic motility subserves large bowel functions, including absorption, storage, propulsion and defaecation. Co-lonic motor dysfunction remains the leading hypothesis to explain symptom generation in chronic constipation, a heterogeneous condition which is extremely prevalent in the general population, and has huge socioeconomic impact and individual suffering. Physiological testing plays a crucial role in patient management, as it is now accepted that symptom-based assessment, although im-portant, is unsatisfactory as the sole means of directing therapy. Colonic manometry provides a direct method for studying motor activities of the large bowel, and this review provides a contemporary understanding of how this technique has enhanced our knowledge of normalcolonic motor physiology, as well as helping to elucidate pathophysiological mechanisms underlying constipation. Methodological approaches, including available catheter types, placement technique and recording protocols, are covered, along with a detailed description of re-corded colonic motor activities. This review also criti-cally examines the role of colonic manometry in current clinical practice, and how manometric assessment may aid diagnosis, classification and guide therapeutic inter-vention in the constipated individual. Most importantly, this review considers both adult and paediatric patients. Limitations of the procedure and a look to the future are also addressed. | Philip G Dinning Marc A Benninga Bridget R Southwell S Mark Scott | 2010 | World Journal of Gastroenterology2010，16，41： | 1 |
| 3 | Cadmium,Lead,and Other Metals in Relation to Semen Quality:Human Evidence forMolybdenum as a Male Reproductive Toxicant显示文摘 | John D M Mary G R Bridget P | 2008 | Environ Health Perspect2008，116，11： | 1 |
| 4 | Impact of land use and land cover change on groundwater recharge and quality in the southwestern US显示文摘 | Bridget R S Robert C R David A S | | 0，，： | 1 |
| 5 | Monoclonal antibodies to hepatitis B e antigen (HBeAg) derived from hepatitis B core antigen (HBcAg):their use in characterization and detection of HBeAg显示文摘 | Bridget Ferns R Tedder RS | 1984 | J Gen Virol1984，65，： | 1 |
| 6 | A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa 显示文摘 | Andrew L G Bridget K Arne R | 2004 | Developmental Cell2004，7，： | 1 |
| 7 | Are Consumers Willing to Pay More for Biodegradable Contain- ers Than for Plastic Ones? Evidence fi'om Hypothetical Con- joint Analysis and Nonhypothetical Experimental Auctions 显示文摘 | Cheng yah Yue Charles R Hall Bridget K Behe | 2010 | Journal of Agricultural and Applied Economics2010，42，4： | 1 |
| 8 | Local and global factors controlling water-energy balances within the Budyko framework 显示文摘 | XU Xianli LIU Wen BRIDGET R S | 2013 | Geophysical Research Letters2013，40，： | 1 |
| 9 | Choosing appropriate techniques for quantifying groundwater recharge显示文摘 | BRIDGET R S HEALY R W COOK P G | 2002 | Hydrogeology Journa12002，10，1： | 1 |
| 10 | Variability in automat- ic activation as an unobtrusive measure of racial attitudes: A bona fide pipeline? 显示文摘 | Russell H F Joni R J Bridget C | 1995 | Journal of Personality and Social Psychology1995，69，6： | 1 |
| 11 | Telepresence, soundscapes and technological expectation:putting the observer into the equation显示文摘 | Gary P Cheryl C B Bridget R etc | 2010 | Virtual Reality2010，，14： | 1 |
| 12 | Evaluation of groundwater storage monitoring with the GRACE satellite:Case study of the High Plains aquifer,central United States显示文摘 | Strassberg Gil Bridget R Scanlon Chambers Don | 2009 | Water Resources Research2009，45，： | 1 |
| 13 | Can we simulate regional groundwater flow in a karst system using equivalent porous media models? Case study,Barton Springs Edwards aquifer,USA显示文摘 | Robert E M Michael E B Brian S | 2003 | Journal of Hydrology2003，276，： | 1 |
| 14 | Choosing ap-propriate tech-niques for quantifying groundwater recharge 显示文摘 | Bridget R Scanlon Healy R W Cook P G | 2002 | Hydrogeology Journal2002，10，1： | 1 |
| 15 | Telepresence, soundscapes andtechnological expectation:putting the observer into the equation显示文摘 | Gary P Cheryl C B Bridget R etc | 2010 | Virtual Reality2010，，14： | 1 |
| 16 | Cadmium,Lead,and other metals in relation to semen quality:Human evidence for molybdenum as a male reproductive toxicant显示文摘 | John D M Mary G R Bridget P | 2008 | Environmental Health Perspectives2008，116，11： | 1 |
| 17 | Telepresence, soundscapes and technological expectation: putting the observer into the equation显示文摘 | Gary P Cheryl C B Bridget R etc | 2010 | Virtual Reality2010，，14： | 1 |
| 18 | Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa显示文摘Multiple endocrine neoplasia 2B(MEN2B) is a rare syndrome caused by an activating mutation of the RET gene, leading to enteric gangliomatosis. This child presented with constipation at 1-mo old, was diagnosed with MEN2 B by rectal biopsy at 4 mo, had thyroidectomy at 9 mo and a colectomy at 4 years. We studied the extent of neuronal and nerve fibre proliferation and which classes of enteric nerves are affected by examining the colon with multiple neuronal antibodies. Resected transverse colon was fixed, frozen, sectioned and processed for fluorescence immunohistochemistry labelling with antibodies against TUJ1, Hu, ChAT, NOS, VIP, SP and CGRP and cKit. Control transverse colon was from the normal margin of Hirschsprung(HSCR) colon(4-year-old) and a child with familial adenomatous polyposis(FAP, 12 year). Myenteric ganglia were increased in size to as wide as the circular muscle. There was a large increase in nerve cells and nerve fibres. ChAT-, NOS-, VIP-and SP-immunoreactive nerve fibres all increased in the myenteric ganglia. NOS-IR nerves preferentially increased in the muscle, while VIP and SP increased in submucosal ganglia and mucosal nerve fibres. The density of ICC was normal. RET overactivation in MEN2B lead to a large increase in intrinsic nerve fibres in the myenteric and submucosal ganglia, with a relative increase in NOS-IR nerve fibres in the circular muscle and VIP and SP in the submucosal ganglia and mucosa. The changes were associated with severe constipation resulting in colectomy at 4 years. | John M Hutson Pam J Farmer Cristal J Peck Chung W Chow Bridget R Southwell | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 1 |
| 19 | Choosing appropriate techniques for quan-tifying groundwater recharge 显示文摘 | Bridget R | 2002 | HydrogeologyJournal2002，10，2： | 1 |
| 20 | Numerical error assessment and a temporal horizon for internal waves in a hydrostatic model 显示文摘 | Hodges B R Bernard Laval Bridget M W | 2006 | Ocean Modelling2006，13，1： | 1 |
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