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| 1 | Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes显示文摘AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLD) listed for liver transplantation. METHODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLD cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets < 150 × 109/L); or(4) ascites without radiological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLD patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELD(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity. | Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 2 | Effects of participation in a martial arts-based antibullying program in elementary schools 显示文摘 | Stuart W T Bridget K B Timothy D N Eric M V Peter F Stephen W T | 2008 | Psychology in the School2008，45，10： | 1 |
| 3 | Newborn screening for congenital hypothyroidism in very-low-birth-weight babies:the need for a second test显示文摘 | Sunita B Bridget W Veronica CW | 2011 | Journal of Inherited Metabolic Disease2011，34，3： | 1 |
| 4 | Choosing appropriate techniques for quantifying groundwater recharge显示文摘 | BRIDGET R S HEALY R W COOK P G | 2002 | Hydrogeology Journa12002，10，1： | 1 |
| 5 | Carcinoid of the rectum risk stratification(CaRRS):A strategy forpreoperative outcome assessment显示文摘 | Bridget N Douglas W | 2007 | Annals of Surgical Oncology2007，14，2： | 1 |
| 6 | Carcinoid of the rectum risk stratification (CaRRS): A strategy for preoperative outcome assessment显示文摘 | Bridget N Douglas W Laura H | 2007 | Annals of Surgical Oncology2007，14，： | 1 |
| 7 | Wetland management: an analysis of past practice and recent policy changes in ontario显示文摘 | BRIDGET S- H ALTERS D W | 2007 | Journal of Environment Management2007，82，： | 1 |
| 8 | Choosing ap-propriate tech-niques for quantifying groundwater recharge 显示文摘 | Bridget R Scanlon Healy R W Cook P G | 2002 | Hydrogeology Journal2002，10，1： | 1 |
| 9 | Vaccination of cattle with Mycobacterium bovines culture Filtrate Proteins andinterleukin-2 for protection against Bovine Tuberculosis显示文摘 | Neil W D Bridget V M A Skinner | 2000 | Infection and Immunity2000，68，： | 1 |
| 10 | Linguistic complexity, speech production, and comprehension in Parkinson's disease:Behavioral and physiologi- cal indices 显示文摘 | Bridget W Anne S | 2011 | Journal of Speech Language and Hearing Re- search2011，54，： | 1 |
| 11 | Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa显示文摘Multiple endocrine neoplasia 2B(MEN2B) is a rare syndrome caused by an activating mutation of the RET gene, leading to enteric gangliomatosis. This child presented with constipation at 1-mo old, was diagnosed with MEN2 B by rectal biopsy at 4 mo, had thyroidectomy at 9 mo and a colectomy at 4 years. We studied the extent of neuronal and nerve fibre proliferation and which classes of enteric nerves are affected by examining the colon with multiple neuronal antibodies. Resected transverse colon was fixed, frozen, sectioned and processed for fluorescence immunohistochemistry labelling with antibodies against TUJ1, Hu, ChAT, NOS, VIP, SP and CGRP and cKit. Control transverse colon was from the normal margin of Hirschsprung(HSCR) colon(4-year-old) and a child with familial adenomatous polyposis(FAP, 12 year). Myenteric ganglia were increased in size to as wide as the circular muscle. There was a large increase in nerve cells and nerve fibres. ChAT-, NOS-, VIP-and SP-immunoreactive nerve fibres all increased in the myenteric ganglia. NOS-IR nerves preferentially increased in the muscle, while VIP and SP increased in submucosal ganglia and mucosal nerve fibres. The density of ICC was normal. RET overactivation in MEN2B lead to a large increase in intrinsic nerve fibres in the myenteric and submucosal ganglia, with a relative increase in NOS-IR nerve fibres in the circular muscle and VIP and SP in the submucosal ganglia and mucosa. The changes were associated with severe constipation resulting in colectomy at 4 years. | John M Hutson Pam J Farmer Cristal J Peck Chung W Chow Bridget R Southwell | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 1 |
| 12 | Numerical error assessment and a temporal horizon for internal waves in a hydrostatic model 显示文摘 | Hodges B R Bernard Laval Bridget M W | 2006 | Ocean Modelling2006，13，1： | 1 |
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