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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 3 | Two-component phase-average turb ulence st atistics downstream of a rotating spoked-wheel wake generator显示文摘 | O'Brien J E Capp S P | 1989 | Journal o f Turbomachinery1989，111，10： | 2 |
| 4 | Analysis of variation in isolates of Rhizoctonia solani by random amplified polymorohic DNA assay显示文摘 | Duncan S Barton J E O'brien P A | 1993 | Mycol Res1993，15，： | 1 |
| 5 | Analysis of variation in isolates of Rhizoctonia solani by random amplified polymorphic DNA assay显示文摘 | Duncan S Barton J E O′Brien P A | 1993 | Mycol Res1993，97，9： | 1 |
| 6 | Molecular phylogeny of the red panda (Ailurus fulgens)显示文摘 | Slattery J P O'Brien S J | 1995 | J Hered1995，86，6： | 1 |
| 7 | High-pressure granulites: Forma tion, recovery of peak conditions and implications for tecton- ics显示文摘 | O'Brien P J R6tzler J | 2003 | Journal of Metamorphic Geology2003，21，： | 1 |
| 8 | The Force Exerted bySurface Waves on Piles 显示文摘 | Morison J R O'Brien M P Johnson J W | 1950 | Journal of Petroleum Technology (S0022-3522)1950，2，5： | 1 |
| 9 | Interannual variability in the eastern subtropical North Pacific Ocean显示文摘 | Leonardi A P Morey S L O'Brien J J | | 0，，： | 1 |
| 10 | Bonding-induced thermal conductance enhancement at inorganic hereto-interfaces using nano- molecular monolayers显示文摘 | O'Brien P J Shenogin S Liu J X | 2013 | Nature Materials2013，12，： | 1 |
| 11 | The Implications of Debt Heterogeneity for R and D Investment and Firm Performance 显示文摘 | David P O'Brien J P Yoshikawa T | 2008 | Academy of Management Journal2008，51，： | 1 |
| 12 | Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment 显示文摘 | Richon V M O'Brien J P | 2002 | Clinical Cancer Res2002，8，3： | 1 |
| 13 | Urinary vascular endothelial growth factor and its correlation with bladder cancer recurrence rates显示文摘 | CREW J P O' BRIEN T BICKNELL R | 1999 | J Urol1999，161，3： | 1 |
| 14 | Molecular cytogenetic definition of the chicken genome: the first complete avian karyotype显示文摘 | Masabanda J S Burt D W O'Brien P C | 2004 | Genetics2004，166，3： | 1 |
| 15 | Linking growth episodes of zircon and metamorphic textures to zircon chemistry: An exam- ple from the ultrahigh-temperature granulites of Rogaland (SW Norway)显示文摘 | M6Uer A O'Brien P J Kennedy A | 2003 | Mineralogy2003，5，： | 1 |
| 16 | Vehicle lateral control for automated highway systems 显示文摘 | O'Brien R T Iglesias P A Urban T J | 1996 | IEEE Trans Contr Syst Technol1996，4，3： | 1 |
| 17 | The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene显示文摘 | O'BRIEN K P HOLM S J NILSSON S | 2001 | J Invest Dermatol2001，116，5： | 1 |
| 18 | Interannual variability in the eastern subtropical North Pacific Ocean显示文摘 | Leonardi A P Morey S L O'Brien J J | 2002 | Journal of Physlcal Oceanography2002，32，： | 1 |
| 19 | Modulating hypoxia-induced hepatocyte injury by affecting intracellular redox state显示文摘 | O'Brien P J | 1995 | Biochim Biophys Acta1995，1269，2： | 1 |
| 20 | Project organizations as social networks显示文摘 | Chinowsky P Diekmann J O'Brien J | 2010 | Journal of Construction Engineering and Management2010，136，： | 1 |
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