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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 3 | Two-component phase-average turb ulence st atistics downstream of a rotating spoked-wheel wake generator显示文摘 | O'Brien J E Capp S P | 1989 | Journal o f Turbomachinery1989，111，10： | 2 |
| 4 | 炎症、癫痫发作和癫痫发生:对人类疾病的探索显示文摘癫痫在历史上被认为是一种神经元信号异常传导的疾病,表现为癫痫发作。随着大量自身抗体的发现和对自身免疫性脑炎认识的不断加深,人们越来越重视先天性和适应性免疫系统在癫痫发作和癫痫发生中的作用。在不同的癫痫发作相关的神经炎症和自身免疫疾病中,不同程度观察到了致病性抗体、补体激活、CD8+细胞毒性T细胞和小胶质细胞激活。这些异常的免疫反应被认为会导致神经元信号传导破坏,产生急性症状性癫痫发作,并且在某些情况下,还会发展为长期的自身免疫性癫痫。虽然早期使用免疫调节疗法可以改善自身免疫性脑炎和自身免疫性癫痫的预后,但患者的识别和治疗方法的选择并不总是明确。本篇综述讨论了免疫系统的不同成分在各种形式的癫痫发作中的作用,包括自身免疫性脑炎、自身免疫性癫痫、Rasmussen脑炎、热性感染相关性癫痫综合征和新发难治性癫痫持续状态。尤其是讨论了在这些疾病中观察到的病理生理学和独特的细胞因子谱,及其与诊断、预后和治疗决策的联系。 | Tan TH Perucca P O'Brien TJ Kwan P 高凡凯(译) 李硕(译) 薛国芳(审) Mastura Monif | 2022 | 癫痫杂志2022，8，4： | 2 |
| 5 | Analysis of variation in isolates of Rhizoctonia solani by random amplified polymorohic DNA assay显示文摘 | Duncan S Barton J E O'brien P A | 1993 | Mycol Res1993，15，： | 1 |
| 6 | Cardiostimulant effects of urotensin Ⅱ in human heart in vitro显示文摘 | Russell FD Molenaar P O Brien DM | 2001 | Br J Pharmacol2001，132，： | 1 |
| 7 | Analysis of variation in isolates of Rhizoctonia solani by random amplified polymorphic DNA assay显示文摘 | Duncan S Barton J E O′Brien P A | 1993 | Mycol Res1993，97，9： | 1 |
| 8 | Molecular phylogeny of the red panda (Ailurus fulgens)显示文摘 | Slattery J P O'Brien S J | 1995 | J Hered1995，86，6： | 1 |
| 9 | The vascular tissue of the lodicules of wheat显示文摘 | ZEE S Y O'BRIEN T P | 1971 | Austral J Biol Sci1971，4，： | 1 |
| 10 | High-pressure granulites: Forma tion, recovery of peak conditions and implications for tecton- ics显示文摘 | O'Brien P J R6tzler J | 2003 | Journal of Metamorphic Geology2003，21，： | 1 |
| 11 | The Force Exerted bySurface Waves on Piles 显示文摘 | Morison J R O'Brien M P Johnson J W | 1950 | Journal of Petroleum Technology (S0022-3522)1950，2，5： | 1 |
| 12 | Concurrent conditions and human Listeriosis,England, 1999-2009显示文摘 | Mook P O Brien SJ Gillespie IA | 2011 | Emerging Infectious Diseases2011，17，1： | 1 |
| 13 | Interannual variability in the eastern subtropical North Pacific Ocean显示文摘 | Leonardi A P Morey S L O'Brien J J | | 0，，： | 1 |
| 14 | Bonding-induced thermal conductance enhancement at inorganic hereto-interfaces using nano- molecular monolayers显示文摘 | O'Brien P J Shenogin S Liu J X | 2013 | Nature Materials2013，12，： | 1 |
| 15 | The Implications of Debt Heterogeneity for R and D Investment and Firm Performance 显示文摘 | David P O'Brien J P Yoshikawa T | 2008 | Academy of Management Journal2008，51，： | 1 |
| 16 | Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment 显示文摘 | Richon V M O'Brien J P | 2002 | Clinical Cancer Res2002，8，3： | 1 |
| 17 | Use of the TLM method to solve nonlinear lumped networks显示文摘 | P B Johns M O'Brien | 1980 | Radio and Electronic Engineers1980，50，： | 1 |
| 18 | Enterovirus sequences resembling coxsackievirus A2 detected in stool and spleen from a girl with fatal myocarditis显示文摘 | Bendig JWA O'Brien PS Muir P | 2001 | J Med Virol2001，64，4： | 1 |
| 19 | Indium sulfide nanorods from single-source precursor显示文摘 | AFZAAL M MALIK M A O'BRIEN P | 2004 | Chem Commun2004，3，： | 1 |
| 20 | Effects of selected polychlorinated biphenyl (PCB) congeners on hepatic glutathione,glutathione-related enzymes,and selenium status:implications for oxidative stress显示文摘 | Twaroski T P O 'Brien M L Robertson L W | 2001 | Biochemical Pharmacology2001，62，3： | 1 |
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