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| 1 | Gut microbiota imbalance and colorectal cancer显示文摘The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. However, alterations to the microbiome caused by environmental changes(e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. Colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of micro-organisms, and the involvement of the microbiota in colorectal carcinogenesis is becoming increasingly clear. Indeed, many changes in the bacterial composition of the gut microbiota have been reported in colorectal cancer, suggesting a major role of dysbiosis in colorectal carcinogenesis. Some bacterial species have been identified and suspected to play a role in colorectal carcinogenesis, such as Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis, Enterococcus faecalis, Clostridium septicum, Fusobacterium spp. and Escherichia coli. The potential pro-carcinogenic effects of these bacteria are now better understood. In this review, we discuss the possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial derived metabolism, oxidative stress and anti-oxidative defenses modulation. We lastly describe how bacterial microbiota modifications could represent novel prognosis markers and/or targets for innovative therapeutic strategies. | Johan Gagnière Jennifer Raisch Julie Veziant Nicolas Barnich Richard Bonnet Emmanuel Buc Marie-Agnès Bringer Denis Pezet Mathilde Bonnet | 2016 | World Journal of Gastroenterology2016，22，2： | 76 |
| 2 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 3 | 45°侧卧位微创前外侧入路应用于全髋关节置换术短期结果显示文摘目的总结45°侧卧位下经微创前外侧入路(OCM)行全髋关节置换术的手术经验以及短期结果回顾。方法回顾性分析18例45°侧卧位经微创前外侧入路(OCM)行全髋关节置换术围手术期及1年随访结果,包括可视化疼痛评分(VAS)和髋关节Harris评分,血红蛋白下降值,异体输血率,住院时间等,进行影像学评价,测量髋臼假体外展角,前倾角以及股骨假体内外翻与沉降程度,并与同期常规后入路行全髋关节置换术组病例进行对照,采用独立样本t检验及卡方检验分别进行组间计量与计数资料比较。结果 OCM组术后48 h VAS评分,术后1周Harris评分,血红蛋白下降值,输血率,平均住院日均优于后入路组;术后1年OCM组平均Harris评分为(93.74±1.80),后入路组(92.24±2.76),差异有统计学意义(t=2.068,P<0.05)。两组病例均无并发症发生。两组间髋臼假体外展角,前倾角比较无差异,股骨假体沉降距离,内外翻角度无差异。结论经OCM入路全髋关节置换术围手术期疼痛轻,失血少,康复快,具有快速康复的优势,具有一定的临床应用前景,但仍需期待更多的前瞻性研究及远期效果报道。 | 李之琛 Olivier Bringer 陈东峰 赵杰 卢伟杰 钱东阳 严广斌 陈玉书 | 2017 | 中华关节外科杂志(电子版)2017，11，6： | 7 |
| 4 | 7.0TMR关节软骨自旋锁定三维自旋-晶格弛豫时间成像与量化分析的实验研究显示文摘目的建立MR关节软骨自旋锁定旋转坐标系中的自旋-晶格弛豫时间(T1ρ)三维成像技术和量化分析方法。方法用7.0TMR机和内径为6cm的圆柱形鸟笼23Na—H射频线圈,采用自旋锁定自动补偿脉冲簇和三维自旋回波序列,自旋锁定时间(spin—lockingtime,TSL)分别为0、10、20、30、40和50ms,自旋锁定频率带宽为440Hz(自旋锁定磁场BSL),对6个不同浓度(1%~6%)琼脂糖凝胶体模和8个猪髌骨分别进行自旋锁定T1ρ成像扫描,建立自旋锁定T1ρ成像技术并评价其重复性。在VnmrJ图像终端上,利用自行编制的软件进行三维重组自旋锁定T1ρWI,并重构T1ρ弛豫时间图;采用人工标注的方法画感兴趣区,分别测定体模与髌骨软骨T1ρWI的信噪比(SNR)与T1ρ值。T1ρ值在各组间的对比,行单因素方差分析;软骨组织与琼脂糖体模SNR随时间对比关系的假设检验,行多因素方差分析。结果关节软骨T1ρWI的SNR值、短自旋锁定时间采集图像的SNR值明显高于长自旋锁定时间采集的图像。在不同自旋锁定时间髌骨软骨T1ρWI,SNR值在48±8~95±8之间;不同自旋锁定时间,正常软骨SNR与1%琼脂糖体模的对比关系不同,当自旋锁定时间〈30ms时,琼脂糖体模的图像SNR均低于正常软骨;〉30ms时,正常软骨的图像SNR均低于1%的琼脂糖体模。随着琼脂糖浓度减少,不同自旋锁定时间采集的图像SNR值逐渐增加。各浓度琼脂糖凝胶体模T1ρWI值测量的变异系数均小于10%,显示重复性好。髌骨关节软骨全层、表层、中间层、深层、钙化层T1ρ值测定结果分别为(68.9±6.3)、(80.7±12.8)、(65.7±7.0)、(82.4±7.7)、(69.7±6.4)ms(F=6.436,P〈0.05)。T1ρ值在软骨表层和深层明显高于中间层、钙化层和软骨全层。结论三维自旋锁定T1ρ成像技术是可行的、敏感的、特异的软骨分子成像技术,T1ρ弛豫时间图可量化测量关节软骨的分层状结构。 | 周智洋 单鸿 Steffen Ringgaard 邹学农 邹立津 李海声 李晓娟 Hans Stcdkilde-Jcrgensen Cody Bringer | 2008 | 中华放射学杂志2008，42，10： | 6 |
| 5 | Reciprocal interactions between gut microbiota and autophagy显示文摘A symbiotic relationship has set up between the gut microbiota and its host in the course of evolution,forming an interkingdom consortium.The gut offers a favorable ecological niche for microbial communities,with the whole body and external factors(e.g.,diet or medications)contributing to modulating this microenvironment.Reciprocally,the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other organs.However,failure in one or another of these two partners can lead to the breakdown in their symbiotic equilibrium and contribute to disease onset and/or progression.Several microbial and host processes are devoted to facing up the stress that could alter the symbiosis,ensuring the resilience of the ecosystem.Among these processes,autophagy is a host catabolic process integrating a wide range of stress in order to maintain cell survival and homeostasis.This cytoprotective mechanism,which is ubiquitous and operates at basal level in all tissues,can be rapidly down-or upregulated at the transcriptional,post-transcriptional,or post-translational levels,to respond to various stress conditions.Because of its sensitivity to all,metabolic-,immune-,and microbial-derived stimuli,autophagy is at the crossroad of the dialogue between changes occurring in the gut microbiota and the host responses.In this review,we first delineate the modulation of host autophagy by the gut microbiota locally in the gut and in peripheral organs.Then,we describe the autophagy-related mechanisms affecting the gut microbiota.We conclude this review with the current challenges and an outlook toward the future interventions aiming at modulating host autophagy by targeting the gut microbiota. | Pierre Lapaquette Jean-Baptiste Bizeau Niyazi Acar Marie-Agnès Bringer | 2021 | World Journal of Gastroenterology2021，27，48： | 4 |
| 6 | Alendronate treatment does not inhibit bone formation within biphasic calcium phosphate ceramics in posterolateral spinal fusion: an experimental study in porcine model显示文摘背景 Biphasic 钙磷酸盐(BCP ) 陶艺作为一个 osteoconductive 矩阵有一个潜在的优点并且让最佳的再吞为骨头形成评价。在针的熔化期间把 BCP 陶艺用作骨头接枝要求在材料并且提供长期的 support.Bisphosphonates 的在邻近的 vertebraes 之间的随后的衔接以内的成骨被报导了延长骨头愈合的过程。在在未知的针的熔化遗体的 BCP 陶艺以内的骨头形成上的 bisphosphonate 治疗的影响。这研究的目的是在 posterolateral 在 BCP 成骨上评估 alendronate 的影响针的有小花梗螺丝钉固定的 fusion.Methods Posterolateral 针的熔化在 22 pigs.BCP 陶艺在腰部的脊骨被执行作为骨头接枝被使用获得在邻近的横向的过程之间的骨头熔化。在处理的十一头猪组织 receivedoral alendronate 为三个月的 10 mg/d 手术后地。在控制组的十一头猪没与 alendronate 接受处理。所有动物经历了 posterolateral 有 BCP 陶艺的针的熔化。熔化率被评估在熔化率由 X 光检查评估了的 operation.Results 以后的三个月在处理组是 27.3% , 20% 在控制组织。用组织学的评估的熔化率在处理组是 18.2% , 20% 在控制组织。熔化质量的吝啬的体积是(3.64 敩 ? 景戠敲獡 ? 慣据牥愠摮搠瑥牥業楮杮琠敨漠瑰浩污琠敲瑡敭瑮趸 ? 趸吗?? | XUE Qing-yun JI Quan LI Hai-sheng ZOU Xue-nong Niels Egund Martin Lind Finn B Christensen Cody Bringer | 2009 | Chinese Medical Journal2009，，22： | 3 |
| 7 | Embedding edit distance to enable private keyword search 显示文摘 | Bringer J Chabanne H | 2012 | Human-centrie Computing and Information Sciences2012，2，1： | 1 |
| 8 | Methyle- netetrahydrofolate reductase ( MTHFR ) C677T polymorphism is associated with osteoporotic vertebral frac- tures, but is a weak predictor of BMD 显示文摘 | Villadsen MM Bringer MH Carstens M | 2005 | Osteoporos Int2005，16，4： | 1 |
| 9 | Growth and Characterization of 200mm SI GaAs Crystals Grown by the VGF Method 显示文摘 | Stenzenberger J Bringer T Bomer F | 2003 | Journal of Crystal Growth2003，250，12： | 1 |
| 10 | Revisting the short-wave spectrum of the sea surface in the light of the weighted curvature approximation 显示文摘 | Bringer A | 2013 | IEEE Geoscience and Remote Sensing Society2013，52，1： | 1 |
| 11 | Influence of Primary PCI on the Mortality of Very Old Patients With ST - segment Elevation Myocardial Infarction 显示文摘 | Zabrocki R Bringer S Faeh A | 2014 | Circulation2014，130，14： | 1 |
| 12 | Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels显示文摘 | SONG H BRINGER M R TICE J D | 2003 | Applied Physics Letters2003，83，22： | 1 |
| 13 | Heat Transfer in the Critical Re- gion显示文摘 | Bringer R P Smith J M | 1957 | AIChE J1957，3，1： | 1 |
| 14 | Computation of three-dimensional unbounded eddy current problem using asympototic boundary conditions显示文摘 | Chen Qinshi Konrad Adalbert Bringer Paul P | 1995 | IEEE Trans on MAG1995，31，3： | 1 |
| 15 | Heat Transfer in the Critical Region 显示文摘 | Bringer R P Smith J M | 1957 | Aiche J1957，3，1： | 1 |
| 16 | Evidence for incomplete charge transfer and La-derived states in the valence bands of endohedrally doped La@ C82显示文摘 | Kessler B Bringer A Cramm S | 1997 | Phys Rev Lett1997，79，： | 1 |
| 17 | Role of the pentose phosphate pathway and the Entner–Doudoroff pathway in glucose metabolism of Gluconobacter oxydans 621H显示文摘 | Janine Richhardt Stephanie Bringer Michael Bott | 2013 | Applied Microbiology and Biotechnology2013，，10： | 1 |
| 18 | Weight nutrition and ho - moral events in women Hum显示文摘 | AsdevantA Bringer JLefebvre P | 1997 | REPROD1997，，： | 1 |
| 19 | Abdominal obesity is associated with ineffective control of cardiovascular risk factors in primary care in France显示文摘 | Dallongeville J Bringer J Bruckert E | 2008 | Diabetes Metab2008，34，： | 1 |
| 20 | Weight, nutrition and hormonal elements in women显示文摘 | Asdevant A Bringer J Lefebvre P | 1997 | Hum Reprod1997，12，11： | 1 |
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