|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bone morphogenetic protein-2 is a negative regulator of hepatocyte proliferation downregulated in the regenerating liver显示文摘AIM: To characterize the expression and dynamic changes of bone morphogenetic protein (BMP)-2 in hepatocytes in the regenerating liver in rats after partial hepatectomy (PH), and examine the effects of BMP-2 on proliferation of human Huh7 hepatoma cells. METHODS: Fifty-four adult male Wistar rats were randomly divided into three groups: A normal control (NC) group, a partial hepatectomized (PH) group and a sham operated (SO) group. To study the effect of liver regeneration on BMP-2 expression, rats were sacrificed before and at different time points after PH or the sham intervention (6, 12, 24 and 48 h). For each time point, six rats were used in parallel. Expression and distribution of BMP-2 protein were determined in regenerating liver tissue by Western blot analysis and immunohistochemistry. Effects of BMP-2 on cell proliferation of human Huh7 hepatoma cell line were assessed using an MTT assay.RESULTS: In the normal liver strong BMP-2 expression was observed around the central and portal veins. The expression of BMP-2 decreased rapidly as measured by both immunohistochemistry and Western blot analysis. This decrease was at a maximum of 3.22 fold after 12 h and returned to normal levels at 48 h after PH. No significant changes in BMP-2 immunoreactivity were observed in the SO group. BMP-2 inhibited serum induced Huh7 cell proliferation.CONCLUSION: BMP-2 is expressed in normal adult rat liver and negatively regulates hepatocyte proliferation. The observed down regulation of BMP-2 following partial hepatectomy suggests that such down regulation may be necessary for hepatocyte proliferation. | Cui-Ping Xu Wen-Min Ji Gijs R van den Brink Maikel P Peppelenbosch | 2006 | World Journal of Gastroenterology2006，12，47： | 10 |
| 2 | Formation of polychlorinated benzenes during the catalytic combustion of chlorobenzene using a Pt/v-Al2O3 catalyst显示文摘 | R W von den Brink R Louw P Mulder | 1998 | Applied Catalysis B:Environmental1998，16，： | 2 |
| 3 | Rare earth major and trace elements in chert from the Franciscan complex and Monterey Group,California, Assessing REE sources to finegrained marine sediments显示文摘 | Murray R W Buchholtz T Brink M R | 1991 | Geochimica et Cosmochimica Acta1991，55，： | 1 |
| 4 | Rare earth, major, and trace element composition of Montereyand DSDP chert and associated host sediment : Assessing the influenceof chemical fractionation during diagenesis 显示文摘 | MURRAY R W TEN BRINK M R B GERLACHDC | 1992 | Geochimica et Cosmochimica Acta1992，56，7： | 1 |
| 5 | A helping hand from neutrophils in T cell-in- dependent antibody responses 显示文摘 | Tangye SG Brink R | 2012 | Nat Immunol2012，13，2： | 1 |
| 6 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 7 | Rare earth elements as indicators of different marine depositional environments in chert and shale显示文摘 | Murray R W Buchholtz ten Brink M R | 1990 | Geology1990，18，： | 1 |
| 8 | Characterizationof recombinant camel chymosin reveals superior properties for thecoagulation of bovine and camel milk显示文摘 | KAPPELER S R BRINK H RAHBEK-NIELSEN H | 2006 | Biochem Biophys ResCommun2006，342，2： | 1 |
| 9 | Genetic, environmental and phenotyp- ic relationships among gestation 1 ength, birth weight, growth traits and age at first calving in beef cattle显示文摘 | Bourdon R M Brinks J S | 1982 | J Anim Sci1982，55，： | 1 |
| 10 | Somatoplastic sterility as a cause of seed failure after interspecific hybridization显示文摘 | COOPER D C BRINK R A | 1940 | Genetics1940，25，： | 1 |
| 11 | The continuous analysis of nitrate and ammonium in aerosols by the steam jet aerosol collector (SJAC): extension and validation of the methodology 显示文摘 | Slanina J Ten Brink H M Otjes R P | 2001 | Atmospheric Environment2001，35，13： | 1 |
| 12 | Characterization of recombinant camel chymosin reveals superior properties for the coagulation of bovine and camel milk显示文摘 | Kappeler S R van den Brink H Rahbek-Nielsen H | 2006 | Biochemical and Biophysical Research Communications2006，342，2： | 1 |
| 13 | Angiotensin Ⅱ stimulates gene ezpreasion of insulike growth factor I and its receptor through effec on Hood procure and food in- take显示文摘 | BRINK M CHRASI J PRICE S R | 1999 | Hypertension1999，34，5： | 1 |
| 14 | Rare earthelements as indicators of different marine depositionalenvironments in chert and shale显示文摘 | Murray R W ten Brink M R B Jones D L | 1990 | Geology1990，18，3： | 1 |
| 15 | Rare earth,major, and trace elements in chert from the Franciscan Complex and Monterey group, California: Assessing REE sources to Fine-grained marine sediments 显示文摘 | MURRAY R W BUEHHOLTZ TEN BRINK M R GERLACH D C | 1991 | Geoehimica et Cosmochimica Acta1991，55，： | 1 |
| 16 | Rare-earth, major, and trace elements in chert from the Franciscan complex and Monterey group, Californian:Assessing REE sources to fine -grained marine sediments 显示文摘 | Murray R W Buchholtzten Brink M R Gerlach D C | 1991 | Geochimica et Cosmochimica Acta1991，55，： | 1 |
| 17 | The good, the bad and the ugly-TFH cells in human health and disease 显示文摘 | Tangye SG Ma CS Brink R | 2013 | Nat Rev Imrnunol2013，13，6： | 1 |
| 18 | Green, cata-lytic oxidation of alcohols in water 显示文摘 | ten Brink G J Arends I W C E Sheldon R A | 2000 | Science2000，287，5458： | 1 |
| 19 | Axiomatizations of the shapley value for cooperative games on antimatroids显示文摘 | Algaba E Bilbao J M Brink R | 2003 | Mathematical Methods of Operations Research2003，57，： | 1 |
| 20 | Leptin is a growth factor for colonic epithelial cells显示文摘 | Hardwick J C Van Den Brink G R Offerhaus G J | 2001 | Gastroenterology2001，121，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员