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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Mirror orientation selection (MOS) : a method for eliminating false positive clones from libraries generated by suppression subtractive hybridization显示文摘 | Rebrikov D V Britanova O V Gurskaya N G | 2000 | Nucleic Acids Res2000，28，20： | 1 |
| 3 | Mirror orientation selection (MOS) : a method for eliminating false positive clones from libraries generated by suppression subtraetive hybridization显示文摘 | Rebrikov D V Britanova O V Gurskaya N G etal | 2000 | Nucleic Acids Research2000，28，20： | 1 |
| 4 | Novel tran- scfiption factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the de- veloping mouse CNS显示文摘 | Britanova O Akopov S Lukyanov S | 2005 | Eur J Neurosci2005，21，3： | 1 |
| 5 | Mirror orientation selection (MOS) : a method for eliminating false positive clones from libraries generated by suppression subtractive hybridization 显示文摘 | Rebrikov D V Britanova O V Gurskaya N G | 2000 | Nucleic Acids Res2000，28，20： | 1 |
| 6 | Sath2 haploinsufiiciencyphenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development 显示文摘 | BRITANOVA O DEPEW M J SCHWARK M | 2006 | Am J Hum Genet2006，79，4： | 1 |
| 7 | Satb2 haploinsufficien- ey phenoeopies 2q32-q33 deletions, whereas loss suggests a fun- damental role in the coordination of jaw development显示文摘 | Britanova O Depew M J Schwark M | 2006 | Am J Hum Genet2006，79，4： | 1 |
| 8 | Mirror orientation selection:a method for eliminating fales positive clones from libraries generated by supre-ssion subtractive hybridization显示文摘 | Rebrikov D V Britanova O V Gurskaya N G | 2000 | Nucleic Acids Res2000，28，20： | 1 |
| 9 | Sath2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development显示文摘 | Britanova O Depew M J Schwark M | 2006 | Am J Hum Genet2006，79，： | 1 |
| 10 | Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent ex- pression in the developing mouse CNS 显示文摘 | Britanova O Akopov S Lukyanov S | 2005 | Eur J Neurosci2005，21，3： | 1 |
| 11 | Satb2 Haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development 显示文摘 | Britanova O Depew M J Schwark M | 2006 | Am J Hum Genet2006，79，4： | 1 |
| 12 | Mirror orientation selection (MOS) : a method for eliminating false positive clones from libraries generated by suppression subtractive hybridization 显示文摘 | Rebrikov D V Britanova O V Nya G | 2000 | Nucleic Acids Res2000，28，20： | 1 |
| 13 | Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS显示文摘 | BRITANOVA O AKOPOV S LUKYANOV S | 2005 | Eur J Neurosci2005，21，3： | 1 |
| 14 | Satb2 haploinsufficiency phenocopies 2q32 - q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development 显示文摘 | Britanova O Depew M J Schwark M | 2006 | Am J Hum Genet2006，79，4： | 1 |
| 15 | Mirror orientation selection(MOS), a method for eliminating false positive clones from libraries generated by suppression subtractive hybridization显示文摘 | Rebrikov D V Britanova O V Gurskaya N G | 2000 | Nucleic Acids Research2000，28，20： | 1 |
| 16 | Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development显示文摘 | Britanova O Depew M J Schwark M | 2006 | Am J Hum Genet2006，79，4： | 1 |
| 17 | Mirror Orientation Selection (MOS) :A Method for Eliminating False Positive Clones from Libraries Generated by Suppression Subtractive Hybridization 显示文摘 | Rebrikov D V Britanova O V Gurskaya N G | 2000 | Nucleic Acids Res2000，28，： | 1 |
| 18 | Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type- dependent expression in the developing mouse CNS 显示文摘 | Britanova O Akopov S Lukyanov S | 2005 | Eur J Neurosci2005，21，3： | 1 |
| 19 | Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell- type-dependent expression in the developing mouse CNS 显示文摘 | Britanova O Akopor S Lukyanov S | 2005 | Eur J Neurosei2005，21，3： | 1 |
| 20 | Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development显示文摘 | Britanova O Depew MJ Schwark M | 2006 | Am J Hum Genet2006，79，4： | 1 |
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