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| 1 | Essential hypertension and oxidative stress:New insights显示文摘Essential hypertension is a highly prevalent pathological condition that is considered as one of the most relevant cardiovascular risk factors and is an important cause of morbidity and mortality around the world. Despite the fact that mechanisms underlying hypertension are not yet fully elucidated,a large amount of evidence shows that oxidative stress plays a central role in its pathophysiology. Oxidative stress can be defined as an imbalance between oxidant agents,such as superoxide anion,and antioxidant molecules,and leads to a decrease in nitric oxide bioavailability,which is the main factor responsible for maintaining the vascular tone. Several vasoconstrictor peptides,such as angiotensin Ⅱ,endothelin-1 and urotensin Ⅱ,act through their receptors to stimulate the production of reactive oxygen species,by activating enzymes like NADPH oxidase andxanthine oxidase. The knowledge of the mechanism described above has allowed generating new therapeutic strategies against hypertension based on the use of antioxidants agents,including vitamin C and E,N-Acetylcysteine,polyphenols and selenium,among others. These substances have different therapeutic targets,but all represent antioxidant reinforcement. Several clinical trials using antioxidants have been made. The aim of the present review is to provide new insights about the key role of oxidative stress in the pathophysiology of essential hypertension and new clinical attempts to demonstrate the usefulness of antioxidant therapy in the treatment of hypertension. | Jaime González Nicolás Valls Roberto Brito Ramón Rodrigo | 2014 | World Journal of Cardiology2014，6，6： | 20 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Effect of biofeedback accompanying occupational therapy and functional electrical stimulation in hemiplegic patients显示文摘 | Maria Inês Paes Louren??o Linamara Rizzo Battistella Christina May Moran de Brito Gracinda Rodrigues Tsukimoto Margarida Harumi Miyazaki | 2008 | International Journal of Rehabilitation Research2008，，1： | 2 |
| 4 | Prevalence and clinical relevance of autoimmune neutropenia in patients with primary Sjogren's syndrome 显示文摘 | Brito Zeron P Soria N Munoz S | 2009 | Semin Arthritis Rheum2009，38，5： | 1 |
| 5 | Adenosine receptors: expression, function and regulation 显示文摘 | Sheth S Brito R Mukherjea D | 2014 | Int J Mol Sci2014，15，2： | 1 |
| 6 | First report of root-knot nematode Meloidogyne enterolobii on to- mato and cucumber in Switzerland 显示文摘 | Kiewnick S Karssen G Brito J A | 2008 | Plant Disease2008，92，9： | 1 |
| 7 | The essential oil of Eucalyptus tereticornis, and its constituents alpha-and beta-pinene, potentiate acetylcholine-induced contractions in isolated rat trachea 显示文摘 | Lima F J Brito T S Freire W B | 2010 | Fitoterapia2010，81，6： | 1 |
| 8 | Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic stenosis显示文摘 | Moura LM Faria S Brito M | 2012 | Am J Cardiovasc Dis2012，2，： | 1 |
| 9 | Corrosion resistance and characterization of metallic coatings deposited by thermal spray on carbon steel显示文摘 | V.R.S. Sá Brito I.N. Bastos H.R.M. Costa | 2012 | Materials and Design2012，，： | 1 |
| 10 | Zero-dimensional model for preliminary design of ablative pulsed plasma Teflon thrusters 显示文摘 | Brito C M Elaskar S A Brito H H | 2004 | Journal of Propulsion and Power2004，20，6： | 1 |
| 11 | Mechanical behaviour of non-structural concrete made with recycled ceramic aggregates 显示文摘 | Brito J de Pereira A S Correia J R | 2005 | Cement & Concrete Composites2005，，27： | 1 |
| 12 | OPAl requires mitofusin 1 to promote mitochondrial fusion 显示文摘 | Cipolat S de Brito OM Dal Zilio B | 2004 | Proc Natl Acad Sci USA2004，101，15： | 1 |
| 13 | Community genomics among stratified microbial assemblages in the ocean's interior显示文摘 | DeLong E F Preston C M Mincer T Rich V Hallam S J Frigaard N U Martinez A Sullivan M B Edwards R Brito B R Chisholm S W Karl D M | | 0，，5760： | 1 |
| 14 | Sintering and Crystallite Growth of Nanocrystalline Copper Doped Tin Oxide显示文摘 | SANTILLI C V PULCINELLI S H BRITO G E S | 1999 | J Phys Chem B1999，103，14： | 1 |
| 15 | Determination of pesticide residues in coconut water by liquid - liquid ex- traction and gas chromatography with electron - capture plus thermionic specific detection and solid - phase ex- traction and high - performance liquid chromatography with ultraviolet detection 显示文摘 | Brito N M Navickiene S Polese L | 2002 | J Chromatogr A2002，957，2： | 1 |
| 16 | TRPV1 : a potential drug target for treating various diseases 显示文摘 | Brito R Sheth S Mukherjea D | 2014 | Cells2014，3，2： | 1 |
| 17 | Passive Thermographic Inspection of Adhered Ceramic Claddings: Limitation and Conditioning Factors显示文摘 | Ecem Edis Inês Flores-Colen Jorge de Brito | 2013 | Journal of Performance of Constructed Facilities2013，，6： | 1 |
| 18 | Determination of trace element concentrations in tomato samples at different stages of maturation by ICP OES and ICP-MS following microwave-assisted digestion显示文摘 | BRESSY F C BRITO G B BARBOSA I S | 2013 | Microchemical Journal2013，109，： | 1 |
| 19 | Fault detection and classification in transmission lines based on wavelet transform and ANN显示文摘 | Silva K M Souza B A Brito N S D | 2006 | IEEE Transactions onPowerDelivery2006，21，4： | 1 |
| 20 | Managing inter- dependencies in supplier networks 显示文摘 | Roseira C Brito C Henneberg S C | 2010 | IndustrialMarketing Management2010，39，6： | 1 |
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