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| 1 | Gastric neuroendocrine tumor: A practical literature review显示文摘Gastric neuroendocrine tumors are gastric neoplasms originating from enterochromaffin type cells and are inserted in a larger group,named gastroenteropancreatic neuroendocrine tumors.They are considered rare and variable in terms of their clinical,morphological and functional characteristics and may be indolent or aggressive.They are classified into types I,II and III,according to their pathophysiology,behavior and treatment.Their diagnosis occurs,in most cases,incidentally during upper digestive endoscopies,presenting as simple gastric polyps.Most cases(type I and type II)are related to hypergastrinemia,can be multiple and are treated by endoscopic resection,whenever possible.The use of somatostatin analogs for tumor control may be one of the options for therapy,in addition to total or subtotal gastrectomy for selected cases.Adjuvant chemotherapy is only reserved for poorly differentiated neuroendocrine carcinomas.Although rare,gastric neuroendocrine tumors have an increasing incidence over the years,therefore deserving more comprehensive studies on its adequate treatment.The present study reviews and updates management recommendations for gastric neuroendocrine tumors. | Gabriel Antonio Roberto Carolina Magalhães Britto Rodrigues Renata D’Alpino Peixoto Riad Naim Younes | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 8 |
| 2 | Pain inhibition through transplantation of fetal neuronal progenitors into the injured spinal cord in rats显示文摘Neuropathic pain after spinal cord injury(SCI) is a complex condition that responds poorly to usual treatments. Cell transplantation represents a promising therapy;nevertheless, the ideal cell type in terms of neurogenic potential and effectiveness against pain remains largely controversial. Here, we evaluated the ability of fetal neural stem cells(fNSC) to relieve chronic pain and, secondarily, their effects on motor recovery. Adult Wistar rats with traumatic SCI were treated, 10 days after injury, with intra-spinal injections of culture medium(sham) or fNSCs extracted from telencephalic vesicles(TV group) or the ventral medulla(VM group) of E/14 embryos. Sensory(von Frey filaments and hot plate) and motor(the Basso, Beattie,Bresnahan locomotor rating scale and inclined plane test) assessments were performed during 8 weeks. Thereafter, spinal cords were processed for immunofluorescence and transplanted cells were quantified by stereology. The results showed improvement of thermal hyperalgesia in the TV and VM groups at 4 and 5 weeks after transplantation, respectively. Moreover, mechanical allodynia improved in both the TV and VM groups at 8 weeks. No significant motor recovery was observed in the TV or VM groups compared with sham. Stereological analyses showed that ~70% of TV and VM cells differentiated into NeuN+ neurons,with a high proportion of enkephalinergic and GABAergic cells in the TV group and enkephalinergic and serotoninergic cells in the VM group. Our study suggests that neuronal precursors from TV and VM, once implanted into the injured spinal cord, maturate into different neuronal subtypes, mainly GABAergic, serotoninergic, and enkephalinergic, and all subtypes alleviate pain, despite no significant motor recovery. The study was approved by the Animal Ethics Committee of the Medical School of the University of S?o Paulo(protocol number 033/14) on March 4, 2016. | Chary M. Batista Eric D. Mariano Camila S. Dale Alexandre F. Cristante Luiz R. Britto Jose P. Otoch Manoel J. Teixeira Matthias Morgalla Guilherme Lepski | 2019 | Neural Regeneration Research2019，14，11： | 3 |
| 3 | Paddy Leaf Disease Detection Using an Optimized Deep Neural Network显示文摘Precision Agriculture is a concept of farm management which makes use of IoT and networking concepts to improve the crop.Plant diseases are one of the underlying causes in the decrease in the number of quantity and quality of the farming crops.Recognition of diseases from the plant images is an active research topic which makes use of machine learning(ML)approaches.A novel deep neural network(DNN)classification model is proposed for the identification of paddy leaf disease using plant image data.Classification errors were minimized by optimizing weights and biases in the DNN model using a crow search algorithm(CSA)during both the standard pre-training and fine-tuning processes.This DNN-CSA architecture enables the use of simplistic statistical learning techniques with a decreased computational workload,ensuring high classification accuracy.Paddy leaf images were first preprocessed,and the areas indicative of disease were initially extracted using a k-means clustering method.Thresholding was then applied to eliminate regions not indicative of disease.Next,a set of features were extracted from the previously isolated diseased regions.Finally,the classification accuracy and efficiency of the proposed DNN-CSA model were verified experimentally and shown to be superior to a support vector machine with multiple cross-fold validations. | Shankaranarayanan Nalini Nagappan Krishnaraj Thangaiyan Jayasankar Kalimuthu Vinothkumar Antony Sagai Francis Britto Kamalraj Subramaniam Chokkaligam Bharatiraja | 2021 | Computers, Materials & Continua2021，，7： | 2 |
| 4 | Improved charge transfer at carbon nanotube electrodes显示文摘 | Britto P J Santhanam KSV Rubio A | 1999 | Adv Mater1999，，11： | 1 |
| 5 | Carbon nanotube electrode for oxidation of dopamine显示文摘 | P J BRITTO K S V SANTHANAM P M AJAYAN | 1996 | Bioelectrochemistry and Bioenergetics1996，41，： | 1 |
| 6 | Laboratory seismic tests on geotextile wrap-faced and geotextile-rein- forced segmental retaining walls 显示文摘 | RAMAKRISHNAN S BUDHU M BRITTO A | 1998 | Geosyntheties International Industrial Fabrics Assoe Int1998，5，1： | 1 |
| 7 | Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania ( Leishmania ) 显示文摘 | Pereira B A Britto C Alves C R | 2012 | Microbial Pathogenesis2012，52，2： | 1 |
| 8 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 9 | From Dynamic Classifier Selection to Dynamic Ensemble Selection 显示文摘 | Ko A Sabourin R Britto Jr A | 2008 | Pattern Recognition2008，41，5： | 1 |
| 10 | Remodelling the upper eyelid in the man- agement of orbitopalpebral neurofibromatosis 显示文摘 | Marchac D Britto JA | 2005 | Br ] Plast Surg2005，58，： | 1 |
| 11 | The regulation of nitrate and ammonium transport systems in plants 显示文摘 | GLASS A D M BRITTO D T KAISER B N | 2002 | Journal of Experimental Botany2002，53，370： | 1 |
| 12 | Viral and atypical bac?terial detection in acute respiratory infection in children under five years显示文摘 | Bezerra PG Britto MC CorreiaJB | 2011 | PLoS ONE2011，6，4： | 1 |
| 13 | Copolymerization of ethylene and 1-hexene with Et2ZrCl2 in hexane 显示文摘 | Britto M L Galland G B Santos J H Z | 2001 | Polymer2001，42，： | 1 |
| 14 | Futile transmembrane NH4+cycling:a cellular hypothesis to explain ammonium toxicity in plants显示文摘 | Britto D T Siddiqi M Y Glass A D M | 2001 | Proceedings of the National Academy of Sciences2001，98，7： | 1 |
| 15 | Novel glioblastoma makers with diagnostic and prognostic value indentified through transeriptome anaiysis显示文摘 | Reddy SP Britto R Vinnakota K | 2008 | Clin Cancer Res2008，14，10： | 1 |
| 16 | Nicotine and α-bungarotoxin midigy the dendritic growth of cholinoceptive neurons in the developing chick tectum 显示文摘 | Britto LRG Lindstrom JM Torrao AS | 2003 | Developmental Brain Res2003，143，1： | 1 |
| 17 | Expression of FGFR2 and FGFR3 in the normal human fetal orbit 显示文摘 | Khan SH Britto JA Evans RD | 2005 | Br J Ophthalmol2005，89，12： | 1 |
| 18 | NH4+ toxicity in higher plants:a critical review显示文摘 | Britto D T Kronzucker H J | 2002 | Journal of Plant Physiology2002，159，6： | 1 |
| 19 | The relationship between p63 and p53 expression in normal and neoplastic breast tissue 显示文摘 | Ribeiro-Silva A Zambelli Ramalho LN Britto Garcia S | 2003 | Arch Pathol Lab Med2003，127，3： | 1 |
| 20 | Aspiration lung injury 显示文摘 | Britto J Demling RH | 1993 | New Horiz1993，1，3： | 1 |
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