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| 1 | 继发于自身免疫性脑炎的急性症状性发作和自身免疫相关癫痫:概念性定义显示文摘发作是自身免疫性脑炎综合征常见且突出的表现。致病性神经元自身抗体检测的进展,使人们对癫痫发作的自身免疫性原因的认识得以提高。通过对发现这些自身抗体患者的临床研究,加深了对这些疾病中的发作特征、治疗和预后的了解。国际抗癫痫联盟(ILAE)自身免疫和炎症工作组对两个诊断实体提出了概念性定义:(a)继发于自身免疫性脑炎的急性症状性发作和(b)自身免疫相关癫痫,后者表明了发作的持久性倾向。在讨论该类疾病的病理生理学、治疗、预后和社会后果时,这样的区别是有意义的。文章讨论了生物标记物在应用这些概念性定义中的作用,并以工作组成员所治疗的患者为例来加以说明。 | Steriade C Britton J Russell CD 刘丹丹(译) 邵晓秋(译) 吴逊(审) 关鸿志(审) | 2020 | 癫痫杂志2020，6，5： | 23 |
| 2 | Iron and non-alcoholic fatty liver disease显示文摘The mechanisms that promote liver injury in non-alcoholic fatty liver disease(NAFLD) are yet to be thoroughly elucidated. As such, effective treatment strategies are lacking and novel therapeutic targets are required. Iron has been widely implicated in the pathogenesis of NAFLD and represents a potential target for treatment. Relationships between serum ferritin concentration and NAFLD are noted in a majority of studies, although serum ferritin is an imprecise measure of iron loading. Numerous mechanisms for a pathogenic role of hepatic iron in NAFLD have been demonstrated in animal and cell culture models. However, the human data linking hepatic iron to liver injury in NAFLD is less clear, with seemingly conflicting evidence, supporting either an effect of iron in hepatocytes or within reticulo-endothelial cells. Adipose tissue has emerged as a key site at which iron may have a pathogenic role in NAFLD. Evidence for this comes indirectly from studies that have evaluated the role of adipose tissue iron with respect to insulin resistance. Adding further complexity, multiple strands of evidence support an effect of NAFLD itself on iron metabolism. In this review, we summarise the human and basic science data that has evaluated the role of iron in NAFLD pathogenesis. | Laurence J Britton V Nathan Subramaniam Darrell HG Crawford | 2016 | World Journal of Gastroenterology2016，22，36： | 14 |
| 3 | Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery显示文摘Pomegranate fruit peel is rich in bioactive plant natural products,such as hydrolyzable tannins and anthocyanins.Despite their documented roles in human nutrition and fruit quality,genes involved in natural product biosynthesis have not been cloned from pomegranate and very little sequence information is available on pomegranate in the public domain.Shotgun transcriptome sequencing of pomegranate fruit peel cDNA was performed using RNA-Seq on the Illumina Genome Analyzer platform.Over 100 million raw sequence reads were obtained and assembled into 9,839 transcriptome assemblies (TAs) (>200 bp).Candidate genes for hydrolyzable tannin,anthocyanin,flavonoid,terpenoid and fatty acid biosynthesis and/or regulation were identified.Three lipid transfer proteins were obtained that may contribute to the previously reported IgE reactivity of pomegranate fruit extracts.In addition,115 SSR markers were identified from the pomegranate fruit peel transcriptome and primers were designed for 77 SSR markers.The pomegranate fruit peel transcriptome set provides a valuable platform for natural product biosynthetic gene and SSR marker discovery in pomegranate.This work also demonstrates that next-generation transcriptome sequencing is an economical and effective approach for investigating natural product biosynthesis,identifying genes controlling important agronomic traits,and discovering molecular markers in non-model specialty crop species. | Nadia Nicole Ono Monica Therese Britton Joseph Nathaniel Fass Charles Meyer Nicolet Dawei Lin Li Tian | 2011 | Journal of Integrative Plant Biology2011，53，10： | 12 |
| 4 | 左前额叶参与非相关词对的语义编码过程──来自光学成像的佐证显示文摘通过研究左前额叶在非相关词对的语义编码过程中的作用,探讨近红外光学成像技术用于脑高级认知活动检测的可行性。被试在两种实验条件下分别学习视觉呈现的20个汉字非相关词对,要求被试或将词对组成一个有意义的句子(深加工),或判断两个词是否具有相同的结构组合(浅加工)。光学成像器即时记录连续光透过额骨及前额皮层后760nm和850nm的漫射光强变化,以此推测相应脑组织的血容量变化。结果表明,与浅加工相比,左下前额叶在深加工时的血容量增多,尤其是背外侧部分。 | 杨炯炯 曾绍群 骆清铭 管林初 匡培梓 龚辉 Britton Chance | 2001 | 心理学报2001，33，1： | 11 |
| 5 | 牧草如何生长——植物生长与放牧管理之关联(英文)显示文摘适当管理饲料饲草资源的基本原则是理解多年生牧草如何生长。长期以来 ,对根系生长有了基本的了解 ,对去叶和环境对根系生长的影响也知之甚多。然而 ,对去叶、干旱及其他环境因素对多年生牧草的影响以及这些牧草对去叶的反应缺乏应有的理解。从牧草返青到开花 ,植物处于短枝阶段 ,适度放牧并不对多年生牧草的健康和活力造成危害 ,因为植物会弥补其失去的叶片。然而 ,当牧草从短枝向长枝阶段 (节间伸长和开花期 )转移时 ,碳水化合物主要用于节间伸长和开花过程。在开花后和休眠前期 ,碳水化合物主要向茎基和植物基部转移 ,以供来年新枝条的发育。因此 ,在花后和休眠前期 ,放牧系统必须被调节到“无放牧”状态。“无放牧”状态 ,如休息、轮牧、延迟轮牧和快速轮牧制 ,其价值在于这种定期的禁牧可提高多年生牧草的活力 ,改善草地的健康状况 ,并且在不利的环境条件下 。 | Ronald E Sosebee David B Wester J Carlos Villalobos Carlton M Britton Changgui Wan Hisham Nofal | 2005 | 草业学报2005，14，1： | 8 |
| 6 | Arterial vs venous blood gas differences during hemorrhagic shock显示文摘AIM: To characterize differences of arterial(ABG) and venous(VBG) blood gas analysis in a rabbit model of hemorrhagic shock. METHODS: Following baseline arterial and venous blood gas analysis, fifty anesthetized, ventilated New Zealand white rabbits were hemorrhaged to and maintained at a mean arterial pressure of 40 mm Hg until a state of shock was obtained, as defined by arterial p H ≤ 7.2 and base deficit ≤-15 mmol/L. Simultaneous ABG and VBG were obtained at 3 minute intervals. Comparisons of p H, base deficit, p CO2, and arteriovenous(a-v) differences were then made between ABG and VBG at baseline and shock states. Statistical analysis was applied where appropriate with a significance of P < 0.05. RESULTS: All 50 animals were hemorrhaged to shockstatus and euthanized; no unexpected loss occurred. Significant differences were noted between baseline and shock states in blood gases for the following parameters: p H was significantly decreased in both arterial(7.39 ± 0.12 to 7.14 ± 0.18) and venous blood gases(7.35 ± 0.15 to 6.98 ± 0.26, P < 0.05), base deficit was significantly increased for arterial(-0.9 ± 3.9 m Eq/L vs-17.8 ± 2.2 m Eq/L) and venous blood gasses(-0.8 ± 3.8 m Eq/L vs-15.3 ± 4.1 m Eq/L, P < 0.05). p CO2 trends(baseline to shock) demonstrated a decrease in arterial blood(40.0 ± 9.1 mm Hg vs 28.9 ± 7.1 mm Hg) but an increase in venous blood(46.0 ± 10.1 mm Hg vs 62.8 ± 15.3 mm Hg), although these trends were non-significant. For calculated arteriovenous differences between baseline and shock states, only the p CO2 difference was shown to be significant during shock.CONCLUSION: In this rabbit model, significant differences exist in blood gas measurements for arterial and venous blood after hemorrhagic shock. A widened p CO2 a-v difference during hemorrhage, reflective of poor tissue oxygenation, may be a better indicator of impending shock. | Kristopher Burton Williams Ashley Britton Christmas Brant Todd Heniford Ronald Fong Sing Joseph Messick | 2014 | World Journal of Critical Care Medicine2014，3，2： | 6 |
| 7 | 用近红外光学漫射成象方法观测语义编码在前额叶的响应显示文摘本文采用近红外光学漫射成象技术成功观测了左右前额区在知觉与语义编码中的活动. 发现大脑在完成上述两任务时,左前额的活动显著地强于右前额,语义加工引起的活动显著地强于知觉加工. 对于每一侧而言,与浅加工相比,深加工时的活动主要集中在下前额叶.上述结果进一步证实了左前额叶在语义加工中的作用. | 曾绍群 杨炯炯 龚辉 骆清铭 Britton Chance | 2000 | 光子学报2000，29，1： | 6 |
| 8 | 编码非相关词对是否具有半球对称性?一项近红外光学成像的研究(英文)显示文摘目的本研究采用近红外光学成像技术(fNIRS),探讨双侧前额叶在非相关词对的语义编码过程中的作用。方法48名被试者分别在深、浅加工2种实验条件下对非相关词对进行编码,光学成像器即时记录在前额叶皮层,波长为760nm和850nm的漫射光强变化,以此推测相应脑组织的血容量变化。结果与浅加工相比,在深加工条件下,双侧前额叶中与背外侧前额叶相对应区域的血容量变化都较为明显,尤其是左侧前额叶。本研究结果并不完全支持HERA模型,但与其它相关的脑成像研究结果相似。结论材料的特异性是影响记忆编码中半球一侧化的重要因素,当需要对刺激间的联系进行加工时,右侧前额叶也会参与记忆的编码过程。本研究还提示fNIRS技术可用于记忆等脑高级认知功能的研究。 | 杨炯炯 曾少群 骆清铭 管林初 匡培梓 龚辉 Lichty Wemara Chance Britton | 2005 | 航天医学与医学工程2005，18，5： | 3 |
| 9 | MITOCHONDRIAL REDOX IMAGING FOR CANCER DIAGNOSTIC AND THERAPEUTIC STUDIES显示文摘Mitochondrial redox states provide important information about energy-linked biological processes and signaling events in tissues for various disease phenotypes including cancer.The redox scanning method developed at the Chance laboratory about 30 years ago has allowed 3D highresolution(∼50×50×10µm^(3))imaging of mitochondrial redox state in tissue on the basis of the fluorescence of NADH(reduced nicotinamide adenine dinucleotide)and Fp(oxidized flavoproteins including flavin adenine dinucleotide,i.e.,FAD).In this review,we illustrate its basic principles,recent technical developments,and biomedical applications to cancer diagnostic and therapeutic studies in small animal models.Recently developed calibration procedures for the redox imaging using reference standards allow quantification of nominal NADH and Fp concentrations,and the concentration-based redox ratios,e.g.,Fp/(Fp+NADH)and NADH/(Fp+NADH)in tissues.This calibration facilitates the comparison of redox imaging results acquired for different metabolic states at different times and/or with different instrumental settings.A redox imager using a CCD detector has been developed to acquire 3D images faster and with a higher in-plane resolution down to 10µm.Ex vivo imaging and in vivo imaging of tissue mitochondrial redox status have been demonstrated with the CCD imager.Applications of tissue redox imaging in small animal cancer models include metabolic imaging of glioma and myc-induced mouse mammary tumors,predicting the metastatic potentials of human melanoma and breast cancer mouse xenografts,differentiating precancerous and normal tissues,and monitoring the tumor treatment response to photodynamic therapy.Possible future directions for the development of redox imaging are also discussed. | LIN Z.LI HE N.XU MAHSA RANJI SHOKO NIOKA BRITTON CHANCE | 2009 | Journal of Innovative Optical Health Sciences2009，2，4： | 3 |
| 10 | 【原创论文】德国东西部睾丸癌后发生第二原发癌的风险关注对侧睾丸癌显示文摘上世纪70年代起以顺铂为基础的化疗使睾丸癌的存活率显著提高。然而,化疗和放疗具有潜在的致癌性。本研究的目的是评估德国睾丸癌存活者患第二原发癌(包括原发组织学类型精原细胞瘤和非精原细胞瘤)的风险。我们确认了德国东部地区(1961-1989年和1996-2008年)癌症登记的16990例睾丸癌和德国西部地区萨尔州(1970.2008年)癌症登记的1401例睾丸癌。我们用标准化发病率(SIRs)和95%N信区间(95%CI)估计第二原发癌的风险。我们将估计的年标准化发病率绘制成图以显示趋势。德国东部1961.1989年观察到301例第二原发癌(SIR:1.9;95%CI:1.7-2.1),1996—2008年观察到159例第二原发癌(SIR:1.7:95%CI:1.4~2.0)。两地癌症登记的对侧睾丸癌增加(SIR:萨尔6.0,德国东部13.9)。与其它地区相比,德国东部精原细胞瘤的SIR增加更为显著。数据分析显示对侧睾丸癌的SIR有稳定的趋势。大多数其它癌症(包括组织学特异性肿瘤)的SIRs的估计精度低,可能与样本量较小有关。睾丸癌患者患第二原发癌尤其是对侧睾丸癌的风险增加,因此应进行严密随访。 | Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 11 | Ultrasound elastography as an adjuvant to conventional ultrasound in the preoperative assessment of axillary lymph nodes in suspected breast cancer: A pilot study显示文摘 | K. Taylor S. O’Keeffe P.D. Britton M.G. Wallis G.M. Treece J. Housden D. Parashar S. Bond R. Sinnatamby | 2011 | Clinical Radiology2011，，11： | 2 |
| 12 | The effects of middle cerebral artery occlusion on central nervous system apoptotic events in normal and diabetic rats显示文摘 | Britton M Rafols J Alousi S | 2003 | Int J Exp Diabetes Res2003，4，1： | 2 |
| 13 | 短周期面波的自动检测算法显示文摘给出了一种短周期瑞雷(Rg)波的自动检测器,其目的是用于三分量台站所记录到的区域(<2.5°震中距)事件。该检测器以17~22s的瑞雷波自动检波方法为模型;我们已经修改了用在近距离和短周期的算法。我们对该检测器在印度中部一群定位很好的矿山爆破和该地区一组地面实测事件进行了检验。Rg波检测器结合了半自动的事件检测系统和定位算法,并被用在连续数据上。为进行前置滤波,对傅里叶方法和基于小波的方法进行了评估。在小波前置滤波后,我们看到了用Rg波检测器估算的后方位角标准偏差的样本,它与系列事件fk3CP波的后方位角相当。结果表明,用Rg震相后方位角定位与用小信噪比的初至震相后方位角定位这两种方法是兼容的。相对于傅里叶前置滤波而言,我们更推荐小波前置滤波,因为在近距离上,在低信噪比的背景上检波,小波前置滤波的一致性更好。 | I. M. Tibuleac J. M. Britton 李忠伟(译) 许健生(校) | 2006 | 世界地震译丛2006，37，6： | 2 |
| 14 | QUANTITATIVE REDOX SCANNING OF TISSUE SAMPLES USING A CALIBRATION PROCEDURE显示文摘The fluorescence properties of reduced nicotinamide adenine dinucleotide(NADH)and oxidizedflavoproteins(Fp)including flavin adenine dinucleotide(FAD)in the respiratory chain are sensitive indicators of intracellular metabolic states and have been applied to the studies of mitochondrial function with energy-linked processes.The redox scanner,a three-dimensional(3D)low temperature imager previously developed by Chance et al.,measures the in vivo metabolicproperties of tissue samples by acquiring fluorescence images of NADH and Fp.The redox ratios,i.e.Fp/(Fp+NADH)and NADH/(Fp+NADH),provided a sensitive index of the mitochondrialredox state and were determined based on relative signal intensity ratios.Here we report thefurther development of the redox scanning technique by using a calibration method to quantifythe nominal concentration of the fluorophores in tissues.The redox scanner exhibited very goodlinear response in the range of NADH concentration between 165–1318µM and Fp between90–720µM using snap-frozen solution standards.Tissue samples such as human tumor mousexenografts and various mouse organs were redox-scanned together with adjacent NADH and Fpstandards of known concentration at liquid nitrogen temperature.The nominal NADH and Fpconcentrations as well as the redox ratios in the tissue samples were quantified by normalizing the tissue NADH and Fp fluorescence signal to that of the snap-frozen solution standards.This calibration procedure allows comparing redox images obtained at different time,independent of instrument settings.The quantitative multi-slice redox images revealed heterogeneity inmitochondrial redox state in the tissues. | HE N.XU BAOHUA WU SHOKO NIOKA BRITTON CHANCE LIN Z.LI | 2009 | Journal of Innovative Optical Health Sciences2009，2，4： | 2 |
| 15 | Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficle显示文摘 | Robert A. Britton Vincent B. Young | 2014 | Gastroenterology2014，，： | 2 |
| 16 | Caenorhabditis elegans conserved in parasitic Biochemical Parasitology A cathepsin L protease for embryogenesis is functionally nematodes 显示文摘 | Britton C Murray L | 2002 | Molecular2002，122，： | 1 |
| 17 | Diabetes enhances apoptosis induced by cerebral ischemia显示文摘 | Li ZG Britton M Sima AA | 2004 | Life Sci2004，76，3： | 1 |
| 18 | The role of hepatic vein Doppler in diagnosing acute rejection following paediatric live transplanation显示文摘 | Britton PD Lomas DJ Coulden RA | 1992 | Clin Radiol1992，45，4： | 1 |
| 19 | Constraint-based functional design verification for conceptual design 显示文摘 | Deng Y M Britton G A Tor S B | 2000 | Computer-Aided Design2000，32，14： | 1 |
| 20 | The ABC of APC 显示文摘 | Fearnhead N S Britton M P Bodmer W F | 2001 | Hum Mol Genet2001，10，7： | 1 |
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