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1直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, comparedThomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) 2002Acta Pharmacologica Sinica2002,23,2:3
2Normal Forms of Symplectic MatricesYiming Long Nankai Institute of Mathematics.Nankai University,Tianjin 300071,P.R.China Di Dong Department of Mathematics.SUNY at Stony Brook,Stony Brook,NY 111794-3651,USA Associate Member of the ICTP 2000Acta Mathematica Sinica,English Series2000,16,2:2
3Free radicals and tissue damage produced by exercise显示文摘Davies KJ Quintanilha AT Brooks GA 0,,04:1
4Free radicals and tissue damage produced by exercise显示文摘Davies KJ Quintanilha AT Brooks GA 1982Biochem Biophys Res Comnlun1982,107,4:1
5Free radicals and tissue damage produced by exercise 显示文摘Davies KJ Quintanilha AT Brooks GA 1982Biochem Bio-phys Res Commun1982,107,4:1
6Free radical and tissue damage produced by exercise 显示文摘Davies K J Quintanilha AT Brooks GA 1982Biochem Biophys Res Commun1982,107,4:1
7Free radical and tissue damage produced by exercise显示文摘Davies KJ Quintanilha AT Brooks GA 1982Biophys Res comm1982,107,:1
8Pharmacokinetin and pharmacodynamic assessment of bioavailability for two prodrugs of mothyprednisolone显示文摘Dalay Yates PT Gregory AT Brooks CD 1997Br J Clin harmacol1997,48,6:1
9Free radicals and tissue damage produced by exercise显示文摘Davies KJA Quintanilha AT Brooks GA 1982Biochem Biophys Res Commu1982,107,:1
10Nanofabrication in Polymer Solutions显示文摘This review covers recent advances in fabrication of nanomaterials in polymer solutions with emphasis on using the self assembled amphiphilic block copolymers in solution to fabricate organic/inorganic composites with nanoscale modifications. The phase behavior of block copolymers in water and the use of templates to form ordered nanostructures are reviewed in detail. Modern physical techniques for nanoscale characterization are also introduced. The authors suggested that this approach should provide new routes to create materials with interesting morphologies for many different applications.Tianbo LIU, Li Zhi LIU, Benjamin CHU *(Department of Chemistry,State University of New York at Stony Brook, Stony Brook,NY 11790 3400,USA) Dedicated to the Occasion of the 80th Birthday of Prof.HUANG Bao Tong and Prof.FENG Zhi Liu 2001应用化学2001,18,5:1
11Free radicals and tissue damage produced by exercise 显示文摘Davies K J Quintanilha AT Brooks GA Et AL 1982BiochemBiophys Res Commun1982,107,4:1
12Contingent self-worth and self- handicapping: Do incremental theorists protect self-esteem? 显示文摘Niiya Y Brook AT Crocker J 2010Self Identity2010,9,3:1
13Identifica- tion of the gene for Nance-Horan syndrome ( NHS ) 显示文摘BROOKS SP EBENEZER ND POOPALASUNDARAM S LEHMANN O J MOORE AT HARDCASTLE AJ 2004J Med Genet2004,41,10:1
14Free radicals and tissue damage produced by exercise显示文摘Davies KJA Quintanilha AT Brooks GA 1982Biochern Biophys Res Communi1982,107,4:1
15Free radical and tissue damage produced by exercise显示文摘Davis KJA Quintanjha AT Brooks GA 1982Biochem Biophy Rescomm1982,107,:1
16Cancer screening in the United States,2010: a review of current American Cancer Society guidelines and issues in cancer screening显示文摘Smith RA Cokkinides V Brooks D et at 2010CA Cancer J Clin2010,60,99:1
17Are you sleeping ? pilot comparison of self- reported and objective measures of sleep quality and duration in an inpatient alcoholism treatment program显示文摘Brooks AT Krumlauf MC Whiting BP 2012Subst Abuse2012,6,:1
18Preliminary experience of carbon fibre cage prostheses for treatment of cervical spine disorder显示文摘Brook NS Rorke AW King AT 1997Br J Neurosurg1997,11,:1
19Free radical and tissue damage produced by exercise显示文摘Davies KJ Quintanilha AT Brooks GA 1982Biophys Res Comm1982,107,:1
20Free radicals and tissue damage produced by exercise显示文摘Davies KJ Quintanilha AT Brooks GA Packer L 0,,:1
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