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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Benefits of the use of blood conservation in scoliosis surgery显示文摘AIM To investigate whether autologous blood transfusion(ABT) drains and intra-operative cell salvage reduced donor blood transfusion requirements during scoliosis surgery.METHODS Retrospective data collection on transfusion requirements of patients undergoing scoliosis surgery is between January 2006 and March 2010. There were three distinct phases of transfusion practice over this time: Group A received 'traditional treatment' with allogeneic red cell transfusion(ARCT) in response to an intra- or postoperative anaemia(Hb < 8 g/d L or a symptomatic anaemia); Group B received intra-operative cell salvage in addition to 'traditional treatment'. In group C,ABT wound drains were used together with both intra-operative cell salvage and 'traditional treatment'.RESULTS Data from 97 procedures on 77 patients,there was no difference in mean preoperative haemoglobin levels between the groups(A: 13.1 g/d L; B: 13.49 g/d L; C: 13.66 g/d L). Allogeneic red cell transfusion was required for 22 of the 37 procedures(59%) in group A,17 of 30(57%) in group B and 16 of 30(53%) in group C. There was an overall 6% reduction in the proportion of patients requiring an ARCT between groups A and C but this was not statistically significant(χ2 = 0.398). Patientsin group C received fewer units(mean 2.19) than group B(mean 2.94)(P = 0.984) and significantly fewer than those in group A(mean 3.82)(P = 0.0322). Mean length of inpatient stay was lower in group C(8.65 d) than in groups B(12.83) or A(12.62).CONCLUSION When used alongside measures to minimise blood loss during surgery,ABT drains and intra-operative cell salvage leads to a reduced need for donor blood transfusion in patients undergoing scoliosis surgery. | Peter R Loughenbury Lyeanda Berry Ben T Brooke Abhay S Rao Robert A Dunsmuir Peter A Millner | 2016 | World Journal of Orthopedics2016，7，12： | 3 |
| 3 | Endoscopic options for treatment of dysplasia in Barrett's esophagus显示文摘Recent advances in the endoscopic treatment of dysplasia in Barrett's esophagus(BE) have allowed endoscopists to provide effective and durable eradication therapies. This review summarizes the available endoscopic eradication techniques for dysplasia in patients with BE including endoscopic mucosal resection, endoscopic submucosal dissection, photodynamic therapy, argon plasma coagulation, radiofrequency ablation and cryotherapy. | R Brooks Vance Kerry B Dunbar | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 3 |
| 4 | Utility of liver biopsy in predicting clinical outcomes after percutaneous angioplasty for hepatic venous obstruction in liver transplant patients显示文摘AIM: To determine utility of transplant liver biopsy in evaluating efficacy of percutaneous transluminal angioplasty(PTA) for hepatic venous obstruction(HVOO). METHODS: Adult liver transplant patients treated with PTA for HVOO(2003-2013) at a single institution were reviewed for pre/post-PTA imaging findings, manometry(gradient with right atrium), presence of HVOO on prePTA and post-PTA early and late biopsy(EB and LB, < or > 60 d after PTA), and clinical outcome, defined as good(no clinical issues, non-HVOO-related death) or poor(surgical correction, recurrent HVOO, or HVOOrelated death). RESULTS: Fifteen patients meeting inclusion criteria underwent 21 PTA, 658 ± 1293 d after transplant.In procedures with pre-PTA biopsy(n = 19), no difference was seen between pre-PTA gradient in 13/19 procedures with HVOO on biopsy and 6/19 procedures without HVOO(8 ± 2.4 mm Hg vs 6.8 ± 4.3 mm Hg; P = 0.35). Post-PTA, 10/21 livers had EB(29 ± 21 d) and 9/21 livers had LB(153 ± 81 d). On clinical follow-up(392 ± 773 d), HVOO on LB resulted in poor outcomes and absence of HVOO on LB resulted good outcomes. Patients with HVOO on EB(3/7 good, 4/7 poor) and no HVOO on EB(2/3 good, 1/3 poor) had mixed outcomes. CONCLUSION: Negative liver biopsy greater than 60 d after PTA accurately identifies patients with good clinical outcomes. | Ammar Sarwar Edward Ahn Ian Brennan Olga R Brook Salomao Faintuch Raza Malik Khalid Khwaja Muneeb Ahmed | 2015 | World Journal of Hepatology2015，7，14： | 2 |
| 5 | p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘 | Dean J L Brook M Clark A R | 1999 | J Biol Chen1999，274，： | 1 |
| 6 | The D allele of the angiotensin convening enzyme gene contributes towards blood LDL- cholesterol levels and the presence of hypertension显示文摘 | Oren l Brook JG Gershoni-Barueh R | 1999 | Atherosclerosis1999，145，： | 1 |
| 7 | A robust layered control system for a mobile robot显示文摘 | Brooks R A | 1986 | IEEE Journal of Robotics and Automation1986，2，1： | 1 |
| 8 | Effects of day/night temperature differential and irradiance on the flower stem quality of Sandersonia aorantiaca显示文摘 | Davies L J Brooking I R Catley J L | 2002 | Scientia Horticulturae2002，，95： | 1 |
| 9 | Detection of nickeliferous rocks by alysus of herbarium species of indicator plants显示文摘 | Brooks R R Lee J Reeves R D | 1977 | Joumal of Geochemical Exploration1977，，5： | 1 |
| 10 | The effect of osteogenic growth factors on bone growth into a ceramic-filled defect around an implant显示文摘 | Clarke S A Brooks R A Lee P T | 2004 | Bone Joint Surg Br2004，22，5： | 1 |
| 11 | Virus infection expands a biased subset of T ceils that bind tetrameric class I peptide complexes 显示文摘 | COLES R M JONES C M BROOKS A G | 2003 | Eur J Immunol2003，33，6： | 1 |
| 12 | A robust layered control system for a mobile robot显示文摘 | BROOKS R A | 1986 | IEEE J Robotics Autom1986，，： | 1 |
| 13 | Self-guided Langevin dynamics simulation method显示文摘 | Wu X Brooks B R | 2003 | Chem Phys Letter2003，381，： | 1 |
| 14 | Molecular cloning of the cDNA for androgen-dependent sperm-coating glycoproteins secreted by the rat epididymis显示文摘 | BROOKS D E MEANS A R WRIGHT E J | 1986 | Eur J Biochem1986，161，： | 1 |
| 15 | A robust layered control system for a mobile robot显示文摘 | Brooks R A | 1986 | IEEE J Robotics and Automation1986，2，1： | 1 |
| 16 | Growth and growth hormone secretion显示文摘 | Brook C G Hindmarsh P C Stanhope R | 1988 | Endocrinology1988，119，2： | 1 |
| 17 | A robust layered control system for a mobile robot 显示文摘 | BROOKS R A | 1986 | IEEE Journal of Robotics and Automation1986，2，1： | 1 |
| 18 | Spectral CT with metal artifacts reduction software for improvement of tumor visibility in the vicinity of gold fiducial markers 显示文摘 | BROOK O R GOURTSOYIANNI S BROOK A | 2012 | Radiology2012，263，3： | 1 |
| 19 | Chemical and biological remediation of the benthos near Atlantic salmon farms 显示文摘 | Brooks K M Stiems A R Mahnken C V W | 2003 | Aquaculture2003，255，： | 1 |
| 20 | Properties of porous media affecting fluid flow 显示文摘 | Brooks R H Corey A T | 1966 | Journal of Irrigation DrainageDivision1966，72，2： | 1 |
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