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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Hot-cor- rosion Resistance of Ni-Cr-A1-Y and Ni-18 % Si SI- loys in Sulfate Eutectic and Sulfate Plus Vanadate Melts at 973 K 显示文摘 | BRUCE M W FRED S P GERALD H M | 2002 | Oxidation of Metals2002，58，56： | 1 |
| 3 | Fermentation of hexose and pentose sugars using a novel ethanologenic Escherichia coli strain显示文摘 | Robert B H Herbert A W Rodney J B | 1998 | Enzyme and Microbial Technology1998，23，： | 1 |
| 4 | 查看详情显示文摘 | H L Nguyen P N Horton M B Hursthouse C Legon D W Bruce | | 0，，： | 1 |
| 5 | Fish assemblages associated with artificial reefs of concrete aggregates or quarry stone offshore Miami Beach,Florida,USA显示文摘 | BRIAN K W BRUCE H RICHARD E S | 2002 | Aquatic Living Resources2002，15，2： | 1 |
| 6 | Occurrence of pulmonary thromboembolism immediately after arthroplasty显示文摘 | Bruce W Vander Wall H Peters M | 2001 | Nucl Med Commun2001，22，： | 1 |
| 7 | Polyaniline nanofibers: Facile synthesis and chemical sensors显示文摘 | Huang J Virji S Bruce H W | 2003 | J Am Chem Soc2003，125，2： | 1 |
| 8 | Methodolo- gies for simulating impacts of climate change on crop produc- tion显示文摘 | JEFFREY W W GERRIT H BRUCE A K | 2011 | Field Crops Research2011，124，： | 1 |
| 9 | Experimental investigation of melt topology in partially melten quartzo-feldspathic aggregates under hydrostatic and non-hydrostatic stress显示文摘 | Gleason G C Bruce V Green H W | 1999 | Journal of Metamorphic Geology1999，17，： | 1 |
| 10 | Cis-acting elements involved in photoregulation of an oat phytochrome promoter in rice显示文摘 | BRUCE W B QUAIL P H | 1990 | Plan Cell1990，，2： | 1 |
| 11 | Phytosterols,phy-tostanols,and their conjugates in foods:structural diversity,quantitative analysis,and health-romoting uses显示文摘 | Robert A M Bruce D W Kevin B H | 2002 | Progress in Lipid Research2002，41，： | 1 |
| 12 | Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex显示文摘 | Huang Ying Wu Zhiping Riwanto Meliana Gao Shengqiang Levison Bruce S Gu Xiaodong Fu Xiaoming Wagner Matthew A Besler Christian Gerstenecker Gary Zhang Renliang Li Xin-Min DiDonato Anthony J Gogonea Valentin Tang W H Wilson Smith Jonathan D | 2013 | Journal of Clinical Investigation2013，，9： | 1 |
| 13 | Standoff detection of weapons and contraband in the 100GHz to 1Thz region显示文摘 | Appleby R Bruce W H | | 0，，11： | 1 |
| 14 | Wasteful commuting显示文摘 | BRUCE W H AILSA R | 1982 | The Journal of Political Economy1982，90，5： | 1 |
| 15 | Polyaniline Nanofibers:Facile Synthesis and Chemical Sensors显示文摘 | Huang J Virji S Bruce H W | 2003 | J Am Chem Soc2003，125，： | 1 |
| 16 | Postinjury multiple organ fail-ure: the role of the gut显示文摘 | Heithan T H Bruce C K David W M | 2001 | Shock2001，15，1： | 1 |
| 17 | Methodologiesfor simulating impacts of climate change on crop production 显示文摘 | JEFFREY W W GERRIT H BRUCE A K | 2011 | Field Crops Research2011，124，： | 1 |
| 18 | Equivalence of Bioimped-ance and Thermodilution in Measuring Cardiac Index After Cardiac Surgery显示文摘 | Scott Sageman W Robert H Bruce D | 2002 | J of Cardiothoracic and Vascular Anesthesia2002，16，1： | 1 |
| 19 | Postinjury multiple organ failure:The role of the gut显示文摘 | Heithan T H Bruce C K David W M | 2001 | Shock2001，15，： | 1 |
| 20 | Occurrence of Pulmonary thromboembolism immediately after arthroplasty显示文摘 | Bruce W Vander Wall H Peters M | 2001 | Nucl Medcommun2001，22，1： | 1 |
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