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| 1 | Cyclooxygenase-2 and the inflammogenesis of breast cancer显示文摘Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) COX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to COX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of COX-2 and PGE-2 expression induces transcription of CYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic CYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit COX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of COX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of COX-2 and the prostaglandin cascade in the 'inflammogenesis of breast cancer'. | Randall E Harris Bruce C Casto Zachary M Harris | 2014 | World Journal of Clinical Oncology2014，5，4： | 15 |
| 2 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 3 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 4 | Marketing Productivity, Marketing Audits and Systems for Marketing Performance Assessment显示文摘 | NEIL A M BRUCE H C | 2002 | Journal of Business Research2002，，55： | 1 |
| 5 | Dynamic chan- ges of left ventricular performance and left atrial volume in- duced by the mueller maneuver in healthy young adults and implications for obstructive sleep apnea, atrial fibrillation, and heart failure显示文摘 | Orban M Bruce C J Pressman GS | 2008 | Am J Cardiol2008，102，11： | 1 |
| 6 | Thermophilic aerobic digestionA reliable and effective process for sludge treatment at sm&ll works显示文摘 | Murray K C Tong A Bruce A M | 1990 | Water Sci Technol1990，22，34： | 1 |
| 7 | Engineering and kinetic characterisation of two glucosy|transferases from Arabidopsis thaliana 显示文摘 | Weis M Lim E K Bruce N C | 2008 | Biochimie2008，90，： | 1 |
| 8 | Automated detection of subpixel hyperspectral targets with continuous and discrete wavelet 显示文摘 | Bruce L M Morgan C Larsen S | 2001 | IEEE Transaction on Geoscience and Remote Sensing2001，39，10： | 1 |
| 9 | Intracardiac measurement of pre-ejection myocardial velocities estimates the transmural extent of viable myocardium early after reperfusion in acute myocardial infarction显示文摘 | Pislaru C Bruce CJ Belohlavek M | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 10 | Cores of inventory centralization games显示文摘 | Bruce C Hartman Moshe Dror M oshe Shaked | 2000 | Games and Economic Behavior2000，，31： | 1 |
| 11 | Financing Constraints and Corporate Investment 显示文摘 | Fazzari Steven M R Glenn Hubbard Bruce C Petersen | 1988 | Brookings Paper on Economic Activity1988，19，1： | 1 |
| 12 | Dietary lipid enhancement of broodstock reproductive performance and egg and larval quality in Atlantic halibut(Hippoglossus hippoglossus)显示文摘 | Mazorra C Bruce M Bell J G | 2003 | Aquaculture2003，227，： | 1 |
| 13 | Insect host location : a volatile situation 显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trends in Plant Science2005，10，6： | 1 |
| 14 | 查看详情显示文摘 | H L Nguyen P N Horton M B Hursthouse C Legon D W Bruce | | 0，，： | 1 |
| 15 | Purification and primary structural charaeterization of prophenoloxidases from Aedes aegypti larvae显示文摘 | Junsuo S L Seong R K Bruce M C | 2005 | Insect Biochem Mol Biol2005，35，： | 1 |
| 16 | Ribotypes and virulence gene polymorphisms suggest three distinct Listeria monocytogenes lineages with differences in pathogenic potential显示文摘 | Wiedmann M J L Bruce C Keating | 1997 | Infect Immun1997，65，： | 1 |
| 17 | Breeding oilseed rape for pod shattering resistance 显示文摘 | Morgan C L Ladbrooke Z L Bruce D M | 2000 | Journal of Agricultural Science2000，135，： | 1 |
| 18 | Removal of arsenic(III) from groundwater by nanoscale zero-valent iron 显示文摘 | Sushil R K Bruce M Laurent C | 2005 | Enviromnental Science & Technology2005，39，5： | 1 |
| 19 | Iron and cobalt ethylene polymerization catalys bearing 2,6-bis (imino) pyridyl ligands: synthesis, structures,and polymerization studies 显示文摘 | BRITOVSEK G J P BRUCE M GIBSON V C | 1999 | Journal of American Chemical Society1999，121，38： | 1 |
| 20 | Ribotypes and viru- lence gene polymorphisms suggest three distinct Listeria mono- cytogenes lineages with differences in pathogenic potential显示文摘 | Wiedmann M Bruce JL Keating C | 1997 | Infect Immun1997，65，7： | 1 |
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