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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Analysis of catheter-Tip (8-mm) and actual tissue temperatures achieved during radiofrequeney ablation at the orifice of the pulmonary vein显示文摘 | BUNCH T J BRUCE G K JOHNSON S B | 2004 | Circulation2004，110，： | 1 |
| 3 | Navier-stokes flow field analysis of compressible flow in a high pressure safety relief valve显示文摘 | BRUCE V WANG T S | 2000 | Journal of Applied Mathematics2000，34，12： | 1 |
| 4 | Designing and rating process heat exchangers 显示文摘 | BRUCE T ROBERT S UMESH R | 1998 | Chemical Processing1998，61，4： | 1 |
| 5 | Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation显示文摘 | Dinger M E Amaral P P Mercer T R Pang K C Bruce S J Gardiner B B | 2008 | Genome Res2008，18，： | 1 |
| 6 | The impact of depressive symptomatology on physical disability:MacArthur Studies of Successful Aging 显示文摘 | BRUCE M L SEEMAN T E MERRILL S S | 1994 | Am J Public Health1994，84，： | 1 |
| 7 | Semiconductive metal oxide ferroelectric memory transistor: a long-retention nonvolatile memory transistor显示文摘 | LIT K HSU S T BRUCE D | 2005 | Appl Phys Lett2005，，12： | 1 |
| 8 | Liquid phasemixing in turbulent bed contactor 显示文摘 | Bruce A E R Sai P S T Krishnaiah K | 2003 | Chemical Engineering Science2003，，58： | 1 |
| 9 | Meta-Analysis of Raloxifene for the Prevention and Treatment of Postmenopausal Osteoporosis显示文摘 | Ann C Peter T Nicole Z Vivian R Bruce W Jonathan A George W Beverley S Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 10 | Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and celiac disease 显示文摘 | BRUCE S E BJARNASON I PETERS T J | 1985 | Clin Sci1985，68，5： | 1 |
| 11 | Correlation techniques,perforation strategies,and recovery factors:An integrated3-D reservoir modeling study,Sirikit Field,Thai-land显示文摘 | Bruce A R Sanlung M Duivenvoorden S T C | 1999 | AAPG Bulletin1999，83，10： | 1 |
| 12 | Meta-Analysis of the Efficacy of Vitamin D Treatment in Preventing Osteoporosis in Postmenopausal Women显示文摘 | Emmanuel P George W Beverley S William G Bruce W Nicole Z Ann C Jonathan A Peter T Robert J Carol G Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 13 | Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders显示文摘 | Bruce S Said T Forest C | 2011 | Fertil Steril2011，96，： | 1 |
| 14 | Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a,micronucleus and Comet assays integrated into 28-day repeat dose studies显示文摘 | Shi J Krsmanovic L Bruce S Kel y T Paranjpe M Szabo K | 2011 | Environ Mol Mutagen2011，52，9： | 1 |
| 15 | HIV Testing Frequency Among Men Who Have Sex With Men Attending Sexually Transmitted Disease Clinics: Implications for HIV Prevention and Surveillance显示文摘 | Donna J Helms Hillard S Weinstock Kristen C Mahle Kyle T Bernstein Bruce W Furness Charlotte K Kent Cornelis A Rietmeijer Akbar M Shahkolahi James P Hughes Matthew R Golden | 2009 | JAIDS Journal of Acquired Immune Deficiency Syndromes2009，，3： | 1 |
| 16 | Liquid holdup in turbulent bed contactor显示文摘 | Bruce A E R Sai P S T Krishnaiah K | 2004 | Chemical Engineering Journal2004，99，3： | 1 |
| 17 | Characterization of liquid phase mixing in turbulent bed contactor through RTD studies显示文摘 | Bruce A E R Sai P S T Krishnaiah K | 2004 | Chemical Engineering Journal2004，104，： | 1 |
| 18 | The role of surface acidity in adsorption of aromatic sulfur heterocycles from fuels显示文摘 | Sachin N A H M S H Bruce J T | 2013 | Fuel2013，105，56： | 1 |
| 19 | Designing and rating process heat exchanges 显示文摘 | BRUCE T ROBERT S UMESH R | 1998 | Chemical Processing1998，61，4： | 1 |
| 20 | Designing and rating process heat exchangers 显示文摘 | Bruce T Robert S Umesh R | 1998 | Chemical Processing1998，61，4： | 1 |
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