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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Organizational Form and Environment: An Analysis of Between-form and Within-form Responses to Environmental Change显示文摘 | James J Hoffman Bruce T Lamont | 2000 | Strategic Management Journal2000，21，8： | 1 |
| 3 | Phosphine residues from phostoxin- treated grain 显示文摘 | Bruce R B Robbins A J Tuft T O | 1962 | Journal of Agricultural and Food Chemistry1962，10，1： | 1 |
| 4 | Learning subjective language 显示文摘 | Wiebe J Wilson T Bruce R Bell M Martin M | 2004 | Computational linguistics2004，30，3： | 1 |
| 5 | Insect host location : a volatile situation 显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trends in Plant Science2005，10，6： | 1 |
| 6 | Perception of plant volatile blends by herbivorous insects-Finding the right mix 显示文摘 | Bruce T J A Pickett J A | 2011 | Phytoehemistry2011，72，13： | 1 |
| 7 | Mesoporous silica- magnetite nanocomposite: fabrication and applications in magnetic bioseparations 显示文摘 | Sen T Sebastianelli A Bruce I J | 2006 | Journal of the American Chemical Society2006，128，： | 1 |
| 8 | Analysis of catheter-Tip (8-mm) and actual tissue temperatures achieved during radiofrequeney ablation at the orifice of the pulmonary vein显示文摘 | BUNCH T J BRUCE G K JOHNSON S B | 2004 | Circulation2004，110，： | 1 |
| 9 | New Sand Additive Alternative for Veining in Thin-walled Castings显示文摘 | P L Zajac J Bruce | 1999 | AFS Transactions1999，107，： | 1 |
| 10 | Insect host location:A volatile situation 显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trends in Plant Sciences2005，10，： | 1 |
| 11 | Surface modification of magnetic nanoparticles with alkoxysi|anes and their application in magnetic biosepara- tions显示文摘 | Bruce I J Sen T | 2005 | Langmuir2005，21，： | 1 |
| 12 | Phosphorylation of inositol 1,4,5-triphosphate receptors in parotid aeinar cells显示文摘 | BRUCE J I SHUTTLEWORTH T J GIOVANNUCCI D R | 2002 | J Biol Chem2002，277，2： | 1 |
| 13 | Mesoporous silica ma* gnetite nano composite: Fabrication and applications in magnetic bioseparations 显示文摘 | Sen T Seba stianelli A Bruce I J | 2006 | J Am Chem Soc2006，，128： | 1 |
| 14 | Transvenous pulmonary embolectomy by catheter device显示文摘 | Greefield L J Bruce T A Nicholus N B | 1971 | Ann Surg1971，74，： | 1 |
| 15 | Learning subjective language 显示文摘 | Wiebe J Wilson T Bruce R | 2004 | Computational Linguistics2004，30，3： | 1 |
| 16 | Response of economi-cally important aphids to components of Hemizygia petiolataesse-ntial oil显示文摘 | Bruce T J Birkett M A Blande J | 2005 | Pest Management Science2005，61，： | 1 |
| 17 | Combined Two-photon Excited Fluorescence and Second Harmonic Generation Backscattering Microscopy of Turbid Tissues 显示文摘 | ZOUMI A ALVIN T Y BRUCE J T | 2002 | Proceedings of SPIE2002，4620，： | 1 |
| 18 | Choice Situation,Refocusing,and Post-Bankruptcy Performance 显示文摘 | Divid D D James J H Bruce T L | 2002 | Journal of Management2002，28，5： | 1 |
| 19 | Surgical strategies for treating patients with pineal region tumors 显示文摘 | Bruce J N Ogden A T | 2004 | J Neurooncol2004，69，13： | 1 |
| 20 | Imaging Cells and Extracellular Matrix in vivo by Using Second-harmonic Generation and Two-photon Excited Fluorescence 显示文摘 | ZOUMI A ALVIN Y BRUCE J T | 2002 | Proc Natl Acad Sci2002，99，11： | 1 |
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