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| 1 | 限制性与自由输血策略对心血管疾病患者非心脏手术效果的影响:系统回顾与Meta分析显示文摘目的比较采取限制性与自由输血策略的心血管疾病患者的非心脏手术结局。数据来源搜集涉及医院红细胞输注阈值的随机控制试验。检索CENTRAL、Medline、EMBase、CINAHL、PubMed、LILACS、NHSBT输血证据库、Clinical Trials.gov、WHO国际临床试验注册平台、国际标准随机对照临床试验编号登记、欧盟临床试验登记。检索时间为2015-11-02之前。试验选择选取发表与未发表的比较限制性与自由输血阈值的随机控制试验,试验均纳入心血管疾病患者。结果检索到41项试验,其中7项试验纳入心血管疾病患者。另选取4项纳入心血管疾病患者的试验。最终共搜集11项纳入心血管疾病患者(n=3 033)的试验进行Meta分析(限制性输血1 514例,自由输血1 519例)。输血阈值与30 d死亡率之间联系的汇集风险比例为1.15〔95%CI(0.88,1.50),P=0.50〕,异质性较小(I^2=14%)。限制性输血患者的急性冠脉综合征风险与自由输血患者相比更高〔9项试验;风险比例1.78,95%CI(1.18,2.70),P=0.01,I^2=0%〕。结论对急性冠脉综合征或慢性心血管疾病患者采取80 g/L以下的限制性输血阈值可能并不安全,对病死率与其他结局的影响并不确定。这些数据可暂时支持对急性或慢性心血管疾病患者使用更加自由的输血阈值(>80 g/L),但有待更具有说服力的高质量的心血管疾病患者随机试验进行验证。 | Docherty AB O' Donnell R Brunskill S 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 12 |
| 2 | Distinct path- ways regulate proapoptotic Nix and BNip3 in cardiac stress 显示文摘 | Galvez A S Brunskill E W Marreez Y | 2006 | J Biol Chem2006，281，3： | 1 |
| 3 | Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomes显示文摘 | Clifford DM Fisher SA Brunskill S J | 2012 | PLoS One2012，7，37： | 1 |
| 4 | Stem cell therapy for chronic ischaemic heart disease and congestive heart failure显示文摘 | Fisher SA Brunskill S J Doree C | 2014 | Cochrane Database Syst Rev2014，4，00： | 1 |
| 5 | Water, salt and nutrient fluxes of tropical tidal salt flats 显示文摘 | Ridd P Sam R Hollins S Brunskil G | 1997 | Mangroves and Salt Marshes1997，，1： | 1 |
| 6 | Red cell transfusion for the management of upper gastrointestinal haemorrhage显示文摘 | Hearnshaw S Brunskill S Doree C | 2009 | Cochrane Database Syst Rev2009，2，00： | 1 |
| 7 | Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy显示文摘 | Eric W Brunskill S Steven Potter | | 0，，： | 1 |
| 8 | A systematic review of randomized controlled trials for plasma exchange in the treat- ment of thrombotic thrombocytopenic purpura 显示文摘 | Brunskill S J Tusold A Benjamin S | 2007 | Transfus Med2007，17，1： | 1 |
| 9 | Sediment provenance in a tropical fluvial and marine context by magnetic ' fingerprinting' of transportable sand fractions 显示文摘 | Maher B A Watkins S J Brunskill G | 2008 | Sedimentology2008，5，： | 1 |
| 10 | Red cell trans- fusion for the management of upper gastyointestinal haemorrhage 显示文摘 | Hearnshaw S Brunskill S Doree C | 2009 | Cochrane Database Syst Rev2009，2，00： | 1 |
| 11 | Bone marrow stem cell treatment for ischemic heart disease in patients with no option of revascularization : a systematic review and meta-analysis显示文摘 | FISHER S A DOREE C BRUNSKILL S J | 2013 | PLoS One2013，8，64： | 1 |
| 12 | Stemcell treatment for acute myocardial infarction显示文摘 | CLIFFORD D M FISHER S A BRUNSKILL S J | 2012 | Cochrane Database Syst Rev2012，，00： | 1 |
| 13 | Terrain trafficability analysis and soil mechanical property identifi- cation for planetary rovers: A survey显示文摘 | Chhaniyara S Brunskill C Yeomans B | 2012 | Journal of Terr- amechanics2012，49，2： | 1 |
| 14 | Global and regional hearing impairment prevalence: an analysis of 42 studies in 29 countries 显示文摘 | Stevens G Flaxman S Brunskill E | 2013 | Eur J Public Health2013，23，1： | 1 |
| 15 | Differential effects of peroxisome proliferator activated receptor -gamma (PPAR gamma) ligands in proximal tubular cells:thiazolidinediones are partial PPAR gamma agonists 显示文摘 | Chana R S Lewington A J Brunskill N J | 2004 | Kidney Int2004，65，6： | 1 |
| 16 | Changes in the gene expression pro-grams of renal mesangial cells during diabetic nephropathy显示文摘 | Brunskill E W Potter S S | 2012 | Bmc Nephrol2012，13，： | 1 |
| 17 | Autolo- gous bone marrow stem cells to treat acute myocardial in- farction: a systematic review 显示文摘 | Martin-Rendon E Brunskill S J Hyde C J | 2008 | Eur Heart J2008，29，15： | 1 |
| 18 | Route of deliveryand baseline left ventricular ejection fraction, key factors of bone-marrow-derived cell therapy for ischaemic heart dis- ease显示文摘 | Brunskill S J Hyde C J Doree C J | 2009 | Eur J Heart Fail2009，11，9： | 1 |
| 19 | Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress显示文摘 | Galvez A S Brunskill E W Marreez Y | 2006 | J Biol Chem2006，281，3： | 1 |
| 20 | Bone marrow stem cell treatment for ischemic heart disease in patients with no option of revascularization: a systematic review and meta-analysis显示文摘 | Fisher SA Doree C Brunskill S J | 2013 | PLoS One2013，8，64： | 1 |
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