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| 1 | Endoclips vs large or small-volume epinephrine in peptic ulcer recurrent bleeding显示文摘AIM:To compare the recurrent bleeding after endoscopic injection of different epinephrine volumes with hemoclips in patients with bleeding peptic ulcer.METHODS:Between January 2005 and December 2009,150 patients with gastric or duodenal bleeding ulcer with major stigmata of hemorrhage and nonbleeding visible vessel in an ulcer bed(Forrest Ⅱa) were included in the study.Patients were randomized to receive a small-volume epinephrine group(15 to 25 mL injection group;Group 1,n = 50),a large-volume epinephrine group(30 to 40 mL injection group;Group 2,n = 50) and a hemoclip group(Group 3,n = 50).The rate of recurrent bleeding,as the primary outcome,was compared between the groups of patients included in the study.Secondary outcomes compared between the groups were primary hemostasis rate,permanent hemostasis,need for emergency surgery,30 d mortality,bleeding-related deaths,length of hospital stay and transfusion requirements.RESULTS:Initial hemostasis was obtained in all patients.The rate of early recurrent bleeding was 30%(15/50) in the small-volume epinephrine group(Group 1) and 16%(8/50) in the large-volume epinephrine group(Group 2)(P = 0.09).The rate of recurrent bleeding was 4%(2/50) in the hemoclip group(Group 3);the difference was statistically significant with regard to patients treated with either small-volume or large-volume epinephrine solution(P = 0.0005 and P = 0.045,respectively).Duration of hospital stay was significantly shorter among patients treated with hemoclips than among patients treated with epinephrine whereas there were no differences in transfusion requirement or even 30 d mortality between the groups.CONCLUSION:Endoclip is superior to both small and large volume injection of epinephrine in the prevention of recurrent bleeding in patients with peptic ulcer. | Neven Ljubicic Ivan Budimir Alen Biscanin Marko Nikolic Vladimir Supanc Davor Hrabar Tajana Pavic | 2012 | World Journal of Gastroenterology2012，18，18： | 11 |
| 2 | Scoring systems for peptic ulcer bleeding: which one to use?显示文摘AIM To compare the Glasgow-Blatchford score(GBS), Rockall score(RS) and Baylor bleeding score(BBS) in predicting clinical outcomes and need for interventions in patients with bleeding peptic ulcers. METHODS Between January 2008 and December 2013, 1012consecutive patients admitted with peptic ulcer bleeding(PUB) were prospectively followed. The pre-endoscopic RS, BBS and GBS, as well as the post-endoscopic diagnostic scores(RS and BBS) were calculated for all patients according to their urgent upper endoscopy findings. Area under the receiver-operating characteristics(AUROC) curves were calculated for the prediction of lethal outcome, rebleeding, needs for blood transfusion and/or surgical intervention, and the optimal cutoff values were evaluated.RESULTS PUB accounted for 41.9% of all upper gastrointestinal tract bleeding, 5.2% patients died and 5.4% patients underwent surgery. By comparing the AUROC curves of the aforementioned pre-endoscopic scores, the RS best predicted lethal outcome(AUROC 0.82 vs 0.67 vs0.63, respectively), but the GBS best predicted need for hospital-based intervention or 30-d mortality(AUROC0.84 vs 0.57 vs 0.64), rebleeding(AUROC 0.75 vs 0.61 vs 0.53), need for blood transfusion(AUROC 0.83 vs0.63 vs 0.58) and surgical intervention(0.82 vs 0.63 vs 0.52) The post-endoscopic RS was also better than the post-endoscopic BBS in predicting lethal outcome(AUROC 0.82 vs 0.69, respectively).CONCLUSION The RS is the best predictor of mortality and the GBS is the best predictor of rebleeding, need for blood transfusion and/or surgical intervention in patients with PUB. There is no one 'perfect score' and we suggest that these two tests be used concomitantly. | Ivan Budimir Sanja Stojsavljevic Neven Barsic Alen Biscanin Gorana Mirosevic Sven Bohnec Lora Stanka Kirigin Tajana Pavic Neven Ljubicic | 2017 | World Journal of Gastroenterology2017，23，41： | 6 |
| 3 | Biliary leakage after urgent cholecystectomy: Optimization of endoscopic treatment显示文摘AIM: To investigate the results of endoscopic treatment of postoperative biliary leakage occurring after urgent cholecystectomy with a long-term follow-up.METHODS: This is an observational database study conducted in a tertiary care center. All consecutive patients who underwent endoscopic retrograde cholangiography(ERC) for presumed postoperative biliary leakage after urgent cholecystectomy in the period between April 2008 and April 2013 were considered for this study. Patients with bile duct transection and biliary strictures were excluded. Biliary leakage was suspected in the case of bile appearance from either percutaneous drainage of abdominal collection or abdominal drain placed at the time of cholecystectomy. Procedural and main clinical characteristics of all consecutive patients with postoperative biliary leakage after urgent cholecystectomy, such as indication for cholecystectomy, etiology and type of leakage, ERC findings and post-ERC complications, were collected from our electronic database. All patients in whom the leakage was successfully treated endoscopically were followed-up after they were discharged from the hospital and the main clinical characteristics, laboratory data and common bile duct diameter were electronically recorded. RESULTS: During a five-year period, biliary leakage was recognized in 2.2% of patients who underwent urgent cholecystectomy. The median time from cholecystectomy to ERC was 6 d(interquartile range, 4-11 d). Endoscopic interventions to manage biliary leakage included biliary stent insertion with or without biliary sphincterotomy. In 23(77%) patients after first endoscopic treatment bile flow through existing surgical drain ceased within 11 d following biliary therapeutic endoscopy(median, 4 d; interquartile range, 2-8 d). In those patients repeat ERC was not performed andthe biliary stent was removed on gastroscopy. In seven(23%) patients repeat ERC was done within one to fourth week after their first ERC, depending on the extent of the biliary leakage. In two of those patients common bile duct stone was recognized and removed. Three of those seven patients had more complicated clinical course and they were referred to surgery and were excluded from long-term follow-up. The median interval from endoscopic placement of biliary stent to demonstration of resolution of bile leakage for ERC treated patients was 32 d(interquartile range, 28-43 d). Among the patients included in the follow-up(median 30.5 mo, range 7-59 mo), four patients(14.8%) died of severe underlying comorbid illnesses.CONCLUSION: Our results demonstrate the great efficiency of the endoscopic therapy in the treatment of the patients with biliary leakage after urgent cholecystectomy. | Neven Ljubii Alen Bianin Tajana Pavi Marko Nikoli Ivan Budimir August Miji Ana Duzel | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 3 |
| 4 | Space partitioning strategies for indoor WLAN positioning with cascade-connected ANN structures显示文摘 | BORENOVIC M NESKOVIC A BUDIMIR D | 2011 | International Journal of Neural Systems2011，21，1： | 1 |
| 5 | Choice of antimicrobial drug for infections caused by Chlamydia trachomatis and Chlamydophila pneunoniae显示文摘 | Zele-Starcevic L Plecko V Budimir A | | 0，，04： | 1 |
| 6 | Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus strains isolated in a multicenter study of nursing home residents in Croatia显示文摘 | Budimir A Pal MP Bo?njak Z | 2014 | Amer J Infect Contr2014，42，11： | 1 |
| 7 | Molecular characterization of methicillin-resistant Staphylococcus aureus bloodstream isolates from Croatia显示文摘 | Budimir A Deurenberg RH Plecko V | 2006 | J Antimicrob Chemother2006，57，2： | 1 |
| 8 | Design of open-loop dual-mode microstrip filters显示文摘 | Athukorala L Budimir D | | 0，，： | 1 |
| 9 | Cytokinin-mediated Axillary ShootFormation in Pinus heldreichi显示文摘 | Stoji5i<^ D Budimir S | 2004 | Biologia Plantanim2004，48，3： | 1 |
| 10 | Design of compact dual-mode microstrip filters显示文摘 | ATHUKORALA L BUDIMIR D | 2010 | IEEE Transactions on Microwave Theory and Techniques2010，58，11： | 1 |
| 11 | Choice of antimicrobial drug for infections caused by Chlamydia trachomatis and Chlamydophila pneumoniae 显示文摘 | Zele-starcevic L Plecko V Budimir A | 2004 | Acta Med Croatica2004，58，4： | 1 |
| 12 | Extension of the dielectric tunability range in ferroelectric materials by electric bias field antiparallel to polarization 显示文摘 | Budimir M Damjanovic D Setter N | 2006 | Appl Phys Lett2006，88，： | 1 |
| 13 | Overview of molecular typing methods for outbreak detection and epidemiological surveillance显示文摘 | Sabat AJ Budimir A Nashev D | 2013 | Euro Surveill2013，18，20： | 1 |
| 14 | 查看详情显示文摘 | Sak-Bisnar M Budimir M Kovac S Kukulj D Duic L | | 0，，： | 1 |
| 15 | Metal ions,Alzheimer's disease and chelation therapy显示文摘 | Budimir A | 2011 | Acta Pharmaceutica2011，61，1： | 1 |
| 16 | Morganella Morganii causing fatal sepsis in a platelet recipient and also isolated from a donors stool显示文摘 | Golubic cepulie B Budimir A Plecko V | 2004 | Transfus Med2004，14，3： | 1 |
| 17 | Somatic embryogenesis and plantlet regeneration from cultured shoots and cotyledons of seedlings from stored seeds of black and white spruce (Picea mariana and Picea glauca)显示文摘 | Attree S M Budimir S Fowke L C | | 0，，01： | 1 |
| 18 | Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods显示文摘 | MILADINOVIC D L BUDIMIR S I MI- HAJILOV-KRSTEV T M | 2012 | Anal Bioanal Chem2012，403，4： | 1 |
| 19 | Morpho-histologieal and bioherbicidal evaluation of wild-type and transformed hairy roots of goosefoot显示文摘 | DMITROVIC S MITIC N BUDIMIR S | 2015 | South African Journal of Botany2015，96，11： | 1 |
| 20 | Molecular characterization of methicillin-resistant Staphylococcus aureus bloodstream isolates from Croatia 显示文摘 | Budimir A Deurenberg RH Plecko V | 2006 | J Antimicrob Chemother2006，57，2： | 1 |
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