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	题名	作者	年代	出处	被引量
1	Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype.	C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf	2014	World Journal of Cardiology2014，6，4：	3
2	Inter-ocular and inter-session reliability of the electroretinogram photopic negative response (PhNR) in nonhuman primates显示文摘	Fortune B Bui BV Cull G	2004	Exp Eye Res2004，78，1：	1
3	Intraocular pressure elevation after subtenon injection of triamcinolone acetonide during uveitis显示文摘	Bui Quoc E Bodaghi B Adam R	2002	J Fr Ophtalmol2002，25，10：	1
4	Knowledge discovery from models of soil properties developed through data mining显示文摘	BUI E N HENDERSON B L VIERGEVER K	2006	Ecological Modelling2006，191，34：	1
5	Isoprenoid biosyn- thesis through the methylerythritol phosphate pathway: The(E)-4-hydroxy-3-methylbut-2-enyl diphosphate syn- thase(GcpE) is a protein显示文摘	Seemann M Bui B T Wolff M	2002	Angew Chem Int Ed Engl2002，41，：	1
6	Extracorporeal membrane oxygenation in lambs through umbilical vessel perfusion: Cardiac and hepatic complication 显示文摘	Chi Bui K Humpheries B Kitagawa H	1992	Biol Neonate1992，61，：	1
7	The gradient of retinal functional changes during acute intraocular pressure elevation 显示文摘	Bui BV Edmunds B Cioffi GA	2005	Invest Ophthalmol Vis Sci2005，46，：	1
8	Effect of PEEP ventilation on re- nal function, plasma renin, aldosterone, neurophysins and urinary ADH, and prostaglandins显示文摘	Annat G Viale JP Bui Xuan B	1983	Anesthesiology1983，58，2：	1
9	Cystain C and carotid intima-media thickness in astmptomtic adults: the multi-ehtnic study of atherosis(MESA)显示文摘	Bui AL Katz R Kestenbaum B	2009	Am J Kindney Dis2009，53，3：	1
10	Effect of Ag addition on the corrosion properties of Sn-based alloys 显示文摘	BUI Q V NAM N D NOH B I KAR A KIM J C4 JUNG S B	2010	Materials and Corrosion2010，61，1：	1
11	Current Staging of Renal Cell Carcinoma显示文摘	Leibovich B C Pantuek A J Bui M H	2003	Urol Clin North Am2003，30，3：	1
12	Methodology to label mixed carbohydrate components by APTS 显示文摘	Bui A Kocsis B Kilar F	2008	Journal of Bio- chemistry and Biophysical Methods2008，70，：	1
13	Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production显示文摘	Bui NT Sengpiel B	2000	J Neurosci2000，20，15：	1
14	Dibenzocyclooctadiene lignans and lanostane derivatives from the roots of Kadsura coccinea and their protective effects on primary rat hepatocyte injury induced by t - butyl hydroperoxide显示文摘	NINH K B BUI V T PHAN V K		0，，11：	1
15	Wavelet analysis reveals dynamics of rat oscillatory potentials显示文摘	Forte J Bui B Vingrys A	2008	J Neurosci Methods2008，169，1：	1
16	pfhrp2 and pfhrp3 polymorphisms in Plasmodiumfalciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic tests显示文摘	Wurtz N Fall B Bui K	2013	Malar J2013，12，：	1
17	Investigating structural and biochemical correlates of ganglion cell dysfunction in streptozotocin-indueed diabetic rats显示文摘	Bui B V Loeliger M Thomas M	2009	Exp Eye Res2009，88，6：	1
18	Tribological behavior of W-DLC coated rubber seals显示文摘	PEI Y T BUI X L ZHOU X B	2008	Surface and Coatings Technology2008，202，9：	1
19	Extracting Causal Re- lations on HIV Drug Resistance from Literature显示文摘	Bui Q C Nuallain B O Boucher C A	2010	BMC Bioinfor- matics2010，11，：	1
20	Development of hybrid rice in Vietnam 显示文摘	Bui B B	2002	Journal of Agriculture and Rural Development2002，，2：	1

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