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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | The development of cutaneous allodynia during a migraine attack:clinical evidence for sequential recruitment of spinal and supraspinal nociceptive neurons in migraine 显示文摘 | Burstein R Cutrer MF Yarnitsky D | 2000 | Brain2000，123，： | 1 |
| 3 | DAML-S:A Semantic Markup Language for Web Services显示文摘 | Burstein M Hobbs J R | 2002 | IEEE Intelligent Systems Journal2002，，7： | 1 |
| 4 | Functional imaging of the trigeminal system: applications to migraine pathophysiology 显示文摘 | Borsook D Burstein R Moulton E | 2006 | Headache2006，46，1： | 1 |
| 5 | Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage Ⅱ or Ⅲ breast cancer a pilot study显示文摘 | Burstein HJ Harris LN Gelman R | 2003 | J Clin Oncol2003，21，： | 1 |
| 6 | Localized effective charges in diatomic crystals显示文摘 | LUCOVSKY G MARTIN R M BURSTEIN E | 1971 | Phys Rev B1971，4，： | 1 |
| 7 | Sensitization of menin- geal sensory neurons and the origin of headaches 显示文摘 | Strassman A M Raymond S A Burstein R | 1996 | Nature1996，384，6609： | 1 |
| 8 | Reactions of pipeline steels in carbon dioxide solutions 显示文摘 | Linter B R Burstein G T | 1999 | Corrosion Science1999，，41： | 1 |
| 9 | Analgesic triptan action in an animal model of intracranial pain:a race against the development of central sensitization显示文摘 | Burstein R Jakubowski M | 2004 | Ann Neurol2004，55，： | 1 |
| 10 | 显示文摘 | Burstein G T Barnett C J Kucernak R J | 1996 | J Electrochem Soc1996，143，7： | 1 |
| 11 | Incidence and evolution of subependymal and intraventricular hemorrhage:a study of infants with birth weght less than 1500 g 显示文摘 | Papile LA Burstein J Burstein R | 1978 | J Pediatr1978，92，： | 1 |
| 12 | Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B1D receptor agonists 显示文摘 | Burstein R | 2004 | PNAS2004，101，12： | 1 |
| 13 | Effect of carbon monoxide on the electrooxidation of hydrogen by tungsten carbide 显示文摘 | McIntyre D R Burstein G T Vossen A | 2002 | J Power Sources2002，107，： | 1 |
| 14 | Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage Ⅱ or Ⅲ breast cancer显示文摘 | Burstein H J Bellon J R Galper S | 2006 | Int J Radiat Oncol Biol Phys2006，64，2： | 1 |
| 15 | Defeating migraine pain with triptans:a race against the development of cutaneous allodynia显示文摘 | Burstein R Collins B Jakubowski M | | 0，，： | 1 |
| 16 | Incidence and evaluation of subependymal and intraventricular hemorrhage:a study of infants with birth weight less than 1 500 g 显示文摘 | Papile LA Burstein J Burstein R | 1978 | J Pediatr1978，92，4： | 1 |
| 17 | Thalamic sensitization transforms localized pain into widespread allodynia显示文摘 | Burstein R Jakubowski M Garcia-Nicas E | | 0，，： | 1 |
| 18 | Development and optimization of a doxorubicin loaded poly (lactic acid) contrast agent for ultrasound directed drug delivery显示文摘 | Eisenbrey JR Burstein OM Kambhampati R | 2010 | J Control Release2010，143，： | 1 |
| 19 | Analgesic triptan action in an animal model of intracranial pain: A race against the development of central sensitization显示文摘 | Burstein R Collins B Jakubowski M | 2004 | Ann Neurol2004，55，： | 1 |
| 20 | Composite hyoid-stemohyoid inter-position graft revisited:UCLA experience 1974-1984显示文摘 | Burstein FD Canalis R Ward PH | 1986 | Laryngo-scope1986，96，5： | 1 |
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