|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples显示文摘瞄准:比较胰腺的腺癌织物标本的基因表示侧面,胰腺的人和腺癌和白血病房间线和正常的胰取样以便区分差别的冒号表示了基因并且在内视镜的指导超声的好针渴望( 指导EUS 的 FNA )由量的即时 RT-PCR ( RT-QPCR )验证基因的一个子集的微分表示标本。方法:包含 1176 基因的商业地奉献的癌症 cDNA 宏数组(地图集人癌症 1.2 ) 被使用。不同统计途径(层次聚类的、主要部件分析(PCA ) 和 SAM ) 被用来分析表示数据。RT-QPCR 和免疫组织化学的研究被用于结果的确认。结果:RT-QPCR 验证了 LCN2 的增加的表示(lipocalin 2 ) 并且第一次在恶意的胰的小块地(织物类型 plasminogen 使活跃之物或 tPA ) 同样与正常相比胰。Immunohistochemical 分析证实了在癌入侵的管的上皮细胞局部性的 LCN2 蛋白质的增加的表示。在与胰腺的腺癌从病人通过指导 EUS 的 FNA 获得的 12 件样品的小块地和 LCN2 抄本的分析与在正常纸巾发现的那些比较显示出显著地增加的表示层次,显示高质量的 RNA 的足够的数量能与这种技术被获得。结论:表示介绍是一个有用方法识别简历标记和潜在的目标基因。在胰腺的癌症的指导 EUS 的 FNA 样品的分子的分析为胰腺的腺癌的诊断作为珍贵策略出现。 | Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse Louis Buscail | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 2 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 3 | Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials. | Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 4 | Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis显示文摘 | B. Bournet A. Souque P. Senesse E. Assenat M. Barthet N. Lesavre A. Aubert D. O’Toole P. Hammel P. Levy P. Ruszniewski M. Bouisson J. Escourrou P. Cordelier L. Buscail | 2009 | Endoscopy2009，，06： | 2 |
| 5 | Antiproliferative effect of somatostatin and analogs显示文摘 | Bousquet C Puente E Buscail L | 2001 | Chemotherapy2001，47，2： | 1 |
| 6 | Oxidation of alumina formers at 1173 K: effect of yttrium ion implantation and yttrium alloying addition 显示文摘 | Cueff R Buscail H Caudron E | 2003 | Corrosion Science2003，45，8： | 1 |
| 7 | Antiproliferation effect of somatostatin and analogs 显示文摘 | Bousquet C Puente E Buscail L | 2001 | Chemotherapy [suppl 2]2001，47，： | 1 |
| 8 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 9 | Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer显示文摘 | Buscail L Saint-Laurent N Chastre E | 1996 | Cancer Res1996，56，8： | 1 |
| 10 | Interventional Endoscopic Ultrasound in Pancreatic Diseases显示文摘 | Louis Buscail Patrick Faure Barbara Bournet Janick Selves Jean Escourrou | 2006 | Pancreatology . 2006 (1-2)2006，，： | 1 |
| 11 | Antiproliferation effect of somatostatin and analogs显示文摘 | Bousquet C Puente E Buscail L | 2001 | Chemotherapy2001，47，1： | 1 |
| 12 | Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclaseactivating peptide显示文摘 | Cambillau C Seva C | 1992 | Gastroenterology1992，103，3： | 1 |
| 13 | Antiproliferation effect of somatostatin and analogs 显示文摘 | Bousquet C Puente E Buscail L | 2001 | Chemotherapy2001，4，2： | 1 |
| 14 | 显示文摘 | Cueff R Buscail H Caudron E | 2003 | Corrosion Science2003，45，8： | 1 |
| 15 | Stimulation of tyrosinephosph atase and inhibition of cell proliferation by somatostatin analogues:Mediation b y human somatostatin receptor subtypes SSTR1 andSSTR2显示文摘 | Delesque N Esteve JP | 1994 | Proc Natl Acad Sci USA1994，81，： | 1 |
| 16 | Direct measurements of carbon and carbonate export from a coral reef ecosystem( Moorea Island, French Polynesia) 显示文摘 | DELESALLE B BUSCAIL R CARBONNE J | 1998 | Coral Reefs1998，17，2： | 1 |
| 17 | Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal显示文摘 | Buscail L Saint LN Chastre E | 1996 | Cancer Res1996，56，： | 1 |
| 18 | Endoscopic ultrasonography in pancreatobiliary disease using radial instruments显示文摘 | Buscail L | 1995 | Gastrointest Endosc Clin N Am1995，5，： | 1 |
| 19 | Stimulation of tyroaine phosphatase and inhibition of cell proliferation by somatostatin analogues:Mediation by human somatostatin receptor subtypes SSTR1 and SSTR显示文摘 | Buscail L Delesque N Esteve JP | 1994 | Proc Natl Acad Sci (USA)1994，81，： | 1 |
| 20 | Sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells显示文摘 | Delesque N Buscail L Esteve JP | 1997 | Cancer Res1997，57，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员