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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | RANDALL A IVES B EASTMAN C | 1974 | Journal of Environmental Economics and Management1974，，1： | 1 |
| 5 | Demonstration of hormesis (increase in fatality rate)by penicillin显示文摘 | Randall W A Price C W Welch H | 1947 | American Journal of Public Health and the Nations Health1947，37，4： | 1 |
| 6 | Phase relations and dielectric properties in the Bi2O3-ZnO-Ta2O5 system显示文摘 | YOUN H J SOGABE T RANDALL C A | 2001 | J Am Ceram Soc2001，84，11： | 1 |
| 7 | Assimilable organic carbon (AOC) and biodegradable dissolved organic carbon (BDOC) : complementary measurements 显示文摘 | ESCOBAR I C RANDALL A A | 2001 | Wat Res2001，35，18： | 1 |
| 8 | Nitrate versus Oxygen Respiration in the Activated Sludge Process显示文摘 | McClintock S A Sherrard J H Novak J T Randall C W | 1988 | Journal WPCF1988，60，3： | 1 |
| 9 | Bacterial growth in distri- bution systems Effect of assimilable organic carbon and biode- gradable dissolved organic carbon显示文摘 | Escobar I C Randall A A Taylor J S | 2001 | Environmental Science -Technology2001，35，17： | 1 |
| 10 | Amplification of padlock probes for DNA diagnostics by cascade rolling circle amplification or the polymerase chain reaction 显示文摘 | THOMAS D C NARDONE G A RANDALL S K | 1999 | Archives of Pathology & Laboratory Medicine1999，123，12： | 1 |
| 11 | Influence of NF on distribution system biostability 显示文摘 | ESCOBAR I C RANDALL A A | 1999 | AWWA1999，91，6： | 1 |
| 12 | Investigation of a high Tc piezoelectric system: ( 1-x ) Bi ( Mgl/2 Til/2 ) O3 -xPbTiO3 显示文摘 | Randall C A Eitel R Jones B | 2004 | Journal of Applied Physics2004，95，7： | 1 |
| 13 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | Randall A Ives B Eastman C | 1974 | Journal of Environ- mental Economics and Management1974，1，2： | 1 |
| 14 | Microwave processing of electroceramic materials and devices显示文摘 | Fang C Y Randal C A Lanagan M T | 2009 | Journal of Electroceramics2009，22，： | 1 |
| 15 | A biochemical hypothesis explaining the response of enhanced biological phosphorus removal biomass to organic substrates显示文摘 | C R Hood A A Randall | 2001 | Water Research2001，35，： | 1 |
| 16 | Grain Size and Domain Size Relations in Bulk Ceramics 显示文摘 | C ao W W Randall C A | 1996 | Journal of Physics and Chemistry of Solids1996，57，10： | 1 |
| 17 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | RANDALL A IVES B EASTMAN C | 1974 | Journal of Environmental Eco-nomics and Management1974，1，2： | 1 |
| 18 | Removal of assimilable organic carbon and biodegradable dissolved organic carbon by reverse osmosis and nanofiltration membranes 显示文摘 | ESCOBAR I C HONG S RANDALL A A | 2000 | Membr Sci2000，175，： | 1 |
| 19 | Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs显示文摘 | RANDALL G GRAKOUI A RICE C M | 2003 | Proc Nat Acad Sci USA2003，100，： | 1 |
| 20 | Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs 显示文摘 | Randall G Grakoui A Rice C M | 2002 | PNAS2002，100，1： | 1 |
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