|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Electrochemical performances of layered LiM1 yM'yO2 (M=Ni, Co; M'=Mg, Al, B) oxides in lithium batteries显示文摘 | Julien C Nazri G A Rougier A | 2000 | Solid State Ionics2000，135，14： | 1 |
| 3 | Stable expression of sialyl Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration显示文摘 | Julien S Lagadec C Krzewinski R | 2005 | Breast Cancer Res Treat2005，90，1： | 1 |
| 4 | Optimized electrochemical performance of LiFePO4 at 60℃ with purity controlled by SQUID magnetometry 显示文摘 | ZAGHIB K RAVET N GAUTHIER M GENDRON F MAUGER A GOODENOUGH J B JULIEN C M | 2006 | Journal of Power Sources2006，163，： | 1 |
| 5 | Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treat- ment of Cancer trial 10902 显示文摘 | van der HAGE J A van de VELDE C J H JULIEN J P | 2001 | J Clin Oneol2001，19，22： | 1 |
| 6 | Structural, magnetic and electrochemical properties of lithium iron orthosilicate 显示文摘 | ZAGHIB K AIT SALAH A RAVET N MAUGER A GENDRON F JULIEN C M | 2006 | J Power Sources2006，160，： | 1 |
| 7 | Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease 显示文摘 | Julien C Tremblay C Emond V | 2009 | J Neuropathol Exp Neurol2009，68，： | 1 |
| 8 | Assessing the risks of exposures to multiple chemicals with a common mechanism of toxicity: how to cumulate? 显示文摘 | Wilkinson C F Christoph G R Julien E | 2000 | Regulatory Toxicology and Pharmacology2000，31，1： | 1 |
| 9 | 显示文摘 | Julien C Ziolkiewicz S Lemal M | 2001 | J Mater Chem2001，11，： | 1 |
| 10 | Review of 5-V electrodes for Li-ion batteries: status and trends显示文摘 | JULIEN C M MAUGER A | 2013 | Ionics2013，19，： | 1 |
| 11 | Structural studies of Li4/3Me5/3O4(Me=Ti,Mn) electrode materials:local structure and electrochemical aspects显示文摘 | Julien C M Massot M Zaghib K | 2004 | J Power Sources2004，136，： | 1 |
| 12 | The importance of the SMN genes in the genetics of sporadic ALS 显示文摘 | Philippe C William C Julien P | 2009 | Amyothophic Lateral Sclerosis2009，10，56： | 1 |
| 13 | Defining the Field of Research in Entrepreneurship 显示文摘 | Brnyat C Julien PA | 2001 | Journal of Business Venturing2001，16，2： | 1 |
| 14 | Beneficial effects of dietary ornega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease显示文摘 | BOUSQUET M SAINT-PIERRE M JULIEN C | 2008 | FASEB I2008，22，4： | 1 |
| 15 | Combustion synthesis and characterization of substituted lithium cobalt oxides in lithium batteries显示文摘 | Julien C Camacho -Lopez M A Mohan T | 2000 | Solid State Ionics2000，135，： | 1 |
| 16 | Capitalizing on informa-tion organization and information visualization for a new-gene-ration catalogue显示文摘 | Julien C A Guastavino C Bouthillier F | | 0，，1： | 1 |
| 17 | Beneficial effects of dietary omega - 3 polyunsaturated fatty acid on toxin - induced neuronal degeneration in an animal model of Parkinson's dis- ease显示文摘 | Bousquet M Saint - Pierre M Julien C | 2008 | FASEB J2008，22，4： | 1 |
| 18 | Usefulness of 2‐[<sup>18</sup>F]‐fluoro‐2‐deoxy‐ d ‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study显示文摘 | Mikael Ebbo Aurélie Grados Eric Guedj Delphine Gobert Cécile Colavolpe Mohamad Zaidan Agathe Masseau Fanny Bernard Jean‐Marie Berthelot Nathalie Morel Fran?ois Lifermann Sylvain Palat Julien Haroche Xavier Mariette Bertrand Godeau Emmanuelle Bernit Nathal | 2014 | Arthritis Care & Research2014，，1： | 1 |
| 19 | Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10902显示文摘 | van der Hage JA van de Velde C J Julien JP | 2001 | J Clin Oncol2001，19，22： | 1 |
| 20 | Controlled user evaluations of information visualization interfaces for text retrieval: Literature review and meta- analysis显示文摘 | Julien C A Leide J E Boutheilier F | 2008 | Journal of the American Society for Information Science and Technology2008，59，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员