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| 1 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 2 | Brazilian biosafety law and the new breeding technologies显示文摘Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two decades.Although this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to country.In recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food security.In Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and management.However,most of new breeding technologies did not exist at that time and were not considered in this law.In2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation system.Briefly,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk assessment.If the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing procedures.Currently,152 GM products are commercially approved in Brazil.In 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six products.It is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops. | Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 5 |
| 3 | Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice 显示文摘 | Omori Y Zaidan Dagli ML Yamakage K | 2001 | Murat Res2001，477，12： | 1 |
| 4 | Semantic wikis and the collaborative construction of ontologies:a case study显示文摘 | Zaidan F.H Bax M.P | | 0，，03： | 1 |
| 5 | Novel approach for high (secure and rate) data hidden within triplex space for exe- cutable file显示文摘 | Zaidan A A Zaidan B B Alanazi O H | 2010 | Scientific Research and Essayss2010，5，15： | 1 |
| 6 | Usefulness of 2‐[<sup>18</sup>F]‐fluoro‐2‐deoxy‐ d ‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study显示文摘 | Mikael Ebbo Aurélie Grados Eric Guedj Delphine Gobert Cécile Colavolpe Mohamad Zaidan Agathe Masseau Fanny Bernard Jean‐Marie Berthelot Nathalie Morel Fran?ois Lifermann Sylvain Palat Julien Haroche Xavier Mariette Bertrand Godeau Emmanuelle Bernit Nathal | 2014 | Arthritis Care & Research2014，，1： | 1 |
| 7 | Challenges of Hidden Data in the Unused Area Two within Executable Files显示文摘 | Naji A W Za idan A A Zaidan B B | 2009 | Journal of Computer Science2009，5，11： | 1 |
| 8 | The sympathetic skin re- sponse in diabetic neuropathy and its relationship to autonomic symp- toms显示文摘 | A1-Moallem MA Zaidan RM Alkali NH | 2008 | Saudi Med J2008，29，4： | 1 |
| 9 | Rate of protamine administration:Its effect on heparin reversal and antithrombin recovery after coronary artery surgery显示文摘 | Zaidan JR Johnson S Brynes R | 1986 | Anesth Analg1986，65，4： | 1 |
| 10 | Meeting the security requirements of electronic medical records in the ERA of high-speed compuing显示文摘 | ALANAZI H O ZAIDAN A A ZAIDAN B B | 2015 | Journal of Medical Systems2015，39，1： | 1 |
| 11 | Modeling of insulated CFRP-strengthened reinforced concrete T- beam exposed to fire 显示文摘 | Hawileh R A Naser M Zaidan W | 2009 | Engineering Structures2009，31，12： | 1 |
| 12 | Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice显示文摘 | Krishna Duro de Oliveira Marcello Vannucci Tedardi Bruno Cogliati Maria Lúcia Zaidan Dagli Sircili MP | 2013 | BioMed Research International2013，，： | 1 |
| 13 | A rare homozygous missense mutation in ATP7B exon 19 in a case of Wilson disease显示文摘 | Majumda R Al Jumech M Zaidan R | 2004 | Eur Neurol2004，51，1： | 1 |
| 14 | The antioxidant defences of brain mitochondria during short-term forebrain ischemia and recirculation inthe rat显示文摘 | Sims NR Williams VK Zaidan E Powell JA | 1998 | Brain Res Mol Brain Res1998，60，： | 1 |
| 15 | Modifications in Connexin Expression in Liver Development and Cancer显示文摘 | Mathieu Vinken Joery de Kock André G. Oliveira Gustavo B. Menezes Bruno Cogliati Maria Lú cia Zaidan Dagli Tamara Vanhaecke Vera Rogiers | 2012 | Cell Communication and Adhesion . 2012 (3-4)2012，，： | 1 |
| 16 | The antioxidant defences of brain mitochondria during short-term forebrain ischemia and recirculation in the rat显示文摘 | Sims NR Williams VK Zaidan E | 1998 | Brain Res Mol Brain Res1998，60，： | 1 |
| 17 | Fibronectin and laminin induce expression of islet cell markers in hepatic oval cells in culture显示文摘 | Leite A R CorrSa-Giannella M L Zaidan Dagli M L | 2007 | Cell Tissue Res2007，327，： | 1 |
| 18 | New technique of hidden data in PE-file with in unused area one显示文摘 | ZAIDAN A A ZAIDAN B B OTHMAN F | 2009 | International Journal of Computer and Electrical Engineering2009，1，1： | 1 |
| 19 | Novel framework for hidden data in the image page within executable file using compu- tation between advanced encryption standard and distortion techniques 显示文摘 | NAJI A W HAMEED S A ZAIDAN B B | 2009 | International Journal of Computer Science and Information Security2009，3，1： | 1 |
| 20 | The sympatheticskin response in diabetic neuropathy and its relationship toautonomic symptoms显示文摘 | AI-Moallem MA Zaidan RM Alkali NH | 2008 | Saudi Med J2008，29，4： | 1 |
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