|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep显示文摘Osteopontin(OPN; also known as Secreted Phosphoprotein 1, SPP1) is a secreted extra-cellular matrix(ECM) protein that binds to a variety of cell surface integrins to stimulate cell-cell and cell-ECM adhesion and communication. It is generally accepted that OPN interacts with apically expressed integrin receptors on the uterine luminal epithelium(LE)and conceptus trophectoderm to attach the conceptus to the uterus for implantation. Research conducted with pigs and sheep has significantly advanced understanding of the role(s) of OPN during implantation through exploitation of the prolonged peri-implantation period of pregnancy when elongating conceptuses are free within the uterine lumen requiring extensive paracrine signaling between conceptus and endometrium. This is followed by a protracted and incremental attachment cascade of trophectoderm to uterine LE during implantation, and development of a true epitheliochorial or synepitheliochorial placenta exhibited by pigs and sheep, respectively. In pigs, implanting conceptuses secrete estrogens which induce the synthesis and secretion of OPN in adjacent uterine LE. OPN then binds to αvβ6 integrin receptors on trophectoderm, and the αvβ3 integrin receptors on uterine LE to bridge conceptus attachment to uterine LE for implantation. In sheep, implanting conceptuses secrete interferon tau that prolongs the lifespan of CL. Progesterone released by CL then induces OPN synthesis and secretion from the endometrial GE into the uterine lumen where OPN binds integrins expressed on trophectoderm(αvβ3) and uterine LE(identity of specific integrins unknown) to adhere the conceptus to the uterus for implantation. OPN binding to the αvβ3 integrin receptor on ovine trophectoderm cells induces in vitro focal adhesion assembly, a prerequisite for adhesion and migration of trophectoderm, through activation of: 1) P70S6 K via crosstalk between FRAP1/MTOR and MAPK pathways; 2) MTOR,PI3 K, MAPK3/MAPK1(Erk1/2) and MAPK14(p38) signaling to stimulate trohectoderm cell migration; and 3) focal adhesion assembly and myosin II motor activity to induce migration of trophectoderm cells. Further large in vivo focal adhesions assemble at the uterine-placental interface of both pigs and sheep and identify the involvement of sizable mechanical forces at this interface during discrete periods of trophoblast migration, attachment and placentation in both species. | Greg A Johnson Robert C Burghardt Fuller W Bazer | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 4 |
| 3 | Uterine biology in pigs and sheep显示文摘There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL) which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species. | Fuller W Bazer Gwonhwa Song Jinyoung Kim Kathrin A Dunlap Michael Carey Satterfield Gregory A Johnson Robert C Burghardt Guoyao Wu | 2012 | Journal of Animal Science and Biotechnology2012，3，3： | 3 |
| 4 | 显示文摘 | Johnson L L Johnson W C O'Brein D L | 1961 | Chemical Engineering Progress Symposium Section1961，35，： | 2 |
| 5 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 6 | A sampling-based computational strategy for representation of epistemic uncertainty in model predictions with evidence theory显示文摘 | Helton J C Johnson J D Oberkampt W L | 2007 | Computer Methods in Applied Mechanics and Engineering2007，196，3740： | 1 |
| 7 | Do viscous polysaccharides slow absorption by inhibiting diffusion or convection?显示文摘 | Edwards C A Johnson I T Read N W | 1988 | European Journal of Clinical Nutrition1988，42，： | 1 |
| 8 | Improved mechanical behavior of bulk metallic glasses containing in situ formed ductile phase dendrite dispersions显示文摘 | Hays C C Kim C P Johnson W L | 2001 | Materials science engineering2001，，304306： | 1 |
| 9 | Adjusting batch effects in microarray expression data using empirical bayes methods显示文摘 | JOHNSON W E LI C RABINOVIC A | 2007 | Biostatistics2007，8，1： | 1 |
| 10 | Ecological Benefits of Riparian Restoration in Urban Water- sheds : Study Design and Preliminary Results 显示文摘 | HESSION W C JOHNSON T E CHARLES D F | 2000 | Environ- mental Monitoring and Assessment2000，63，： | 1 |
| 11 | Waterrelations in winter wheat as drought resistance indicators 显示文摘 | Sehonfeld MA Johnson R C Carver B F Mornhinweg D W | 1988 | Crop Science1988，28，3： | 1 |
| 12 | Reinventing your business model显示文摘 | JOHNSON M W CHRISTENSEN C M KAGERMANN H | 2008 | Harvard Business Review2008，86，12： | 1 |
| 13 | SUPCRT92: A software package for calculating the standard molal thermodynamic properties of minerals, gases, aqueous species, and reactions from 1 to 5000 bar and 0 to 1000℃ 显示文摘 | Johnson J W Oelders E H Helgeson H C | 1992 | Computers & Geosciences1992，18，7： | 1 |
| 14 | Fracture toughness and fatigue-crack propagation in a Zr-Ti-Cu-Ni-Be bulk metallic glass显示文摘 | Gilbert C J Ritchie M R O Johnson W L | 1997 | Appl Phys Lett1997，71，4： | 1 |
| 15 | Improving nitrogen use efficiency for cereal production显示文摘 | Ruan W R Johnson C V | 1999 | Agronomy Journal1999，91，： | 1 |
| 16 | Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent,pirfenidone:results of a prospective,open-label Phase Ⅱ study显示文摘 | Raghu G Johnson W C Lockhart D | 1999 | Am J Respir Crit Care Med1999，159，41： | 1 |
| 17 | Novel renoprotective actions of erythropoietin: new uses for an old hormone 显示文摘 | Johnson D W Forman C Vesey D A | 2006 | Nephrology (Carhon)2006，11，4： | 1 |
| 18 | Woodland expansion in the Platte River, Nebraska: patterns and causes显示文摘 | Johnson W C 1994 | 1994 | Ecol Monogr1994，64，： | 1 |
| 19 | A Molec- ular Dynamics Study of Scale Effects on the Fric- tion of Single- asperity Contacts 显示文摘 | Zhang L C Johnson K L Cheong W C D | 2001 | Tribology Letters2001，10，12： | 1 |
| 20 | Reinventing your business model 显示文摘 | JOHNSON M W CHRISTENSEN C M KAGERMANN H | 2008 | Harvard Business Review2008，86，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员