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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | 急性肺血栓栓塞症患者溶栓治疗后的远期预后分析显示文摘目的 分析急性大面积肺血栓栓塞症 (PTE)患者溶栓治疗后的远期预后。方法 对2 60例急性PTE患者进行溶栓治疗并随访 ,分析其临床资料及引起远期临床事件 [死亡、再发深静脉血栓形成、再发PTE、慢性血栓栓塞性肺动脉高压和 (或 )右心衰竭、抗凝治疗出现大出血、依赖家庭氧疗 ]的危险因素。结果 2 60例PTE患者在住院期间死亡 2 2例 (8 5 % ) ,其中 1 5例 (62 8% )死于PTE。随访 2 2 7例患者 ,为期 3 9~ 8 4年 ,死亡 72例 (31 7% ) ,其中有 2 1例患者死于再发PTE。对随访资料完整的 1 65例患者进行远期临床事件的危险因素分析 ,单因素分析显示 ,既往有血栓栓塞病史、抗凝治疗不足 6个月、植入下腔静脉滤器、溶栓后超声心动图仍显示右室功能障碍和 (或 )扩大、溶栓后超声多普勒仍测得肺动脉收缩压 >50mmHg、出院前核素肺通气 /灌注扫描显示肺血管床阻塞 >30 %与远期临床事件的发生相关 ;多变量分析显示 ,溶栓后超声心动图仍显示右室功能障碍和 (或 )扩大、溶栓后超声多普勒仍测得肺动脉收缩压 >50mmHg、出院前核素肺通气 /灌注扫描显示肺血管床阻塞 >30 %是PTE远期预后的独立危险因素。结论 通过高危因素的确立 ,可予患者更积极的治疗 。 | 刘品明 Nicolas Meneveau Franois Schiele Jean-Pierre Bassand | 2002 | 中华内科杂志2002，41，11： | 11 |
| 3 | Predictors of long-term clinical outcome of patients with acute massive pulmonary embolism after thrombolytic therapy显示文摘To assess the in-hospital clinical course and the long-term evolution of acute massive pulmonary embolism after thrombolytic therapy and to identify predictors of adverse clinical outcome Methods A total of 260 patients hospitalized from January 1989 to October 1998 were retrospectively reviewed and followed up for 3 9 to 8 4 years Baseline characteristics and variables pre- and post-thrombolysis were identified Particular attention was paid to the clinical events, including death, recurrent thromboembolism, chronic thromboembolic pulmonary hypertension, and major bleeding attributable to the use of anticoagulants Kaplan-Meier event-free survival curves were generated Univariate analysis by means of the log-rank test was used to test each candidate variable for association with clinical outcome Multivariate analysis with the Cox proportional hazard model was used to determine independent predictors of the long-term outcome Results The in-hospital mortality rate was 8 5%, with 68 2% due to pulmonary embolism itself, and the follow-up mortality rate was 31 7%, with 29 2% due to recurrent embolism Factors associated with an adverse outcome in univariate analysis were: (1) prior thromboembolic diseases; (2) duration of anticoagulant therapy <6 months; (3) inferior vena caval filter placement; (4) acute right ventricular dysfunction/dilation detected echocardiographically after thrombolysis; (5) Doppler recording of pulmonary artery systolic pressure >50 mmHg after thrombolysis; and (6) greater than 30% obstruction of pulmonary vasculature identified by pulmonary ventilation/perfusion scintigraphy before hospital discharge Multivariate analysis identified three independent predictors of poor long-term outcome for patients with acute massive pulmonary embolism after thrombolysis; which were: (1) Doppler recording of pulmonary artery systolic pressure >50 mm Hg, with relative risk of 3 78 and a 95% confidence interval of 2 70 to 4 86; (2) echocardiographic evidence of right ventricular dysfunction/dilatation (relative risk: 2 18; 95% confidence interval: 1 48 to 2 88); and (3) greater than 30% obstruction of pulmonary vasculature documented by lung scan (relative risk: 1 99; 95% confidence interval: 1 25 to 2 70) Conclusion The study showed that Doppler echocardiographic assessments after thrombolytic therapy and ventilation/perfusion scintigraphy prior to hospital discharge are valuable to establishment of new baseline characteristics, which is informative for risk stratification and prognostication of the long-term outcome for patients with acute massive pulmonary | 刘品明 Nicolas Meneveau Francois Schiele Jean Pierre Bassand | 2003 | Chinese Medical Journal2003，，4： | 10 |
| 4 | 经皮冠状动脉介入术中止血活性的早期改变及与纤溶酶原激活剂抑制物-1基因多态性的相关性显示文摘目的探讨经皮冠状动脉介入(PCI)术中冠状动脉内血浆纤溶酶原激活剂抑制物-1(PAI-1)、D-二聚体(D-D)、凝血因子Ⅶ(FⅦa)及可溶性P选择素(CD62P)活性在球囊扩张和支架植入前后的早期改变及其与PAI-1基因多态性的相关性,评估其对急性支架血栓形成的预测价值。方法选择稳定型心绞痛患者20例,按标准方法行冠状动脉造影且证实冠状动脉狭窄均在70%以上。术中冠状动脉内血样采集顺序依次为:球囊扩张前冠状动脉入口处(Ostium)用引导导管,球囊扩张15min以后及支架植入后15min通过血栓吸引器穿过病灶在病变远端采血。结果PAI-1基因多态性在本组中分布为4G/5G型最多(12例,60%),4G/4G型其次(6例,30%),5G/5G型最少(2例,10%)。4G和5G等位基因频率分别为60%和40%。具有PAI-14G/5G基因型患者冠状动脉内血浆PAI-1、D-D以及FⅦ活性在球囊扩张后较球囊扩张前明显升高且有统计学意义(P均为0.01),然而这些指标在球囊扩张前与支架植入后比较无显著性差异。结论球囊扩张较支架植入更易损伤血管内皮并导致冠状动脉内局部、早期止血活性的一过性增高,具有PAI-14G/5G基因型患者对这种反应较为敏感。PCI术前双联抗血小板药物可以有效抑制血小板活性。 | 艾力曼.马合木提 Nicolas Meneveau Francois Schiele Jean-Pierre Bassand | 2007 | 介入放射学杂志2007，16，9： | 4 |
| 5 | Early local intracoronary platelet activation after drug-eluting stent placement显示文摘在冠的干预以后的背景早本地的血小板激活在尖锐 stent 血栓(著名计算机生产厂商) 的增加的风险识别病人。然而,早在跟随 drug-eluting stent ( DES )培植的冠的循环在血小板激活变化从来没是在 26 连续选任的马厩的未来的研究的 reported.Methods 咽峡炎病人,血小板激活被在 DES 或赤裸的金属 stent ( BMS )的培植前后测量可溶的 glycoprotein V ( sGPV )和 P-selectin ( CD62P )分析。所有病人是有 clopidogrel (300 mg 装载剂量) 和阿司匹林的 pretreated (75 mg 口头上地) 在过程前的日子。血样品从冠的口被拉并且 10 -对与更低的基线一致的损害 site.Results 远侧的 20 公里临床的风险, CD62P 和 sGPV 的层次在正常参考以内范围,两个在冠的口并且对在 CD62P 和 sGPV 的 procedure.The 层次没显著地改变的经皮的冠的干预(打印机控制语言)前的损害远侧( CD62P :(31.1 他们区域比率(1.13he 瘤是穿正常白人衣服的 evaluated.With creatinine | Ailiman Mahemuti Nicolas Meneveau Marie-France Seronde FrancoisSchiele Mariette Mercier Evelyne Racadotand Jean-Pierre Bassand | 2007 | Chinese Medical Journal2007，，22： | 3 |
| 6 | Value of intravascular ultrasound imaging in following up patients with replacement of the ascending aorta for acute type A aortic dissection显示文摘背景 intravascular 的价值在有为大动脉的解剖(广告)是的尖锐类型 A 的上升主动脉的代替的病人的超声( IVUS )成像这研究的 unknown.The 目的是从2002年9月在这 setting.Methods 估计 IVUS 成像的潜在的使用到2005年7月,有 9 MHz 探查的 IVUS 成像与学习为尖锐类型与上升主动脉的代替在他们中的 5 个上集中了的怀疑或建立的 AD.This 在一系列 16 个连续病人被执行 AD. | HU Wei Francois Schiele Nicolas Meneveau Marie-France Seronde Pierre Legalery Fiona Caulfield Jean-Frangois Bonneville Sidney Chocron Jean-Pierre Bassand | 2008 | Chinese Medical Journal2008，，21： | 3 |
| 7 | 药物涂层支架与金属裸支架对稳定型心绞痛患者局部冠状动脉循环组织因子水平早期影响的比较显示文摘目的比较药物涂层支架(DES)与金属裸支架(BMS)置入前后冠状动脉循环内局部血浆组织因子(TF)水平的变化,探讨DES对血浆TF水平的早期改变及其对急性支架内血栓(AST)形成的意义。方法入选稳定型心绞痛患者26例,按标准方法行冠状动脉造影证实有冠状动脉狭窄均在70%以上。其中15例置入DES(DES组),11例置入BMS(BMS组)。全部患者术前给予阿司匹林、氯吡格雷口服,支架置入前静脉给予低分子质量肝素。PCI术中冠状动脉内血样采集顺序依次为:支架置入前后冠状动脉入口处(ostium)用引导导管,支架置入后15 min通过血栓吸引器穿过病灶在病灶下方(beyond the lesion)采血。血浆TF水平检测采用酶联免疫双抗体夹心法(ELISA)。结果PCI术前26例患者在冠状动脉入口处与病灶下方冠状动脉循环内的TF基线水平比较差异无统计学意义(31.50±7.05 ng/L比31.40±7.30 ng/L,P=0.748),但高于正常参考值3倍;支架置入后15min在冠状动脉入口处(29.60±6.96 ng/L比31.50±7.05 ng/L,P=0.135)与病灶下方(30.70±7.70 ng/L比31.40±6.30 ng/L,P=0.230)冠状动脉循环内的TF水平与术前比较,差异亦无统计学意义。术后15min,DES组和BMS组冠状动脉入口处(31.20±4.37 ng/L比30.70±5.39 ng/L,P=0.674)及病灶下方(31.60±5.39 ng/L比29.00±7.96 ng/L,P=0.789)TF水平差异均无统计学意义。结论稳定型心绞痛患者冠状动脉循环血内存在大量的TF。DES和BMS两种支架均不引起冠状动脉内局部、早期血浆TF水平的改变。 | 艾力曼·马合木提 Nicolas Meneveau 刘品明 Francois Schiele Jean-Pierre Bassand | 2008 | 中国介入心脏病学杂志2008，16，3： | 2 |
| 8 | Potential interest of intra-aorta ultrasound imaging for the diagnosis of aortic penetrating atherosclerotic ulcer显示文摘 | Hu Wei Francois Schiele Nicolas Meneveau Marie-France Seronde Pierre Legalery Jean-Francois Bonneville Sidney Chocron Jean-Pierre Bassand | 2006 | The International Journal of Cardiovascular Imaging2006，，5： | 1 |
| 9 | The potential value of intravascular ultrasound imaging in diagnosis of aortic intramural hematoma显示文摘Objective To evaluate the potential value of intravascular ultrasound(IVUS)imaging in the diagnosis of aortic intramural hematoma(AIH).Methods From September 2002 to May 2005,a consecutive series of 15 patients with suspected aortic dissection(AD)underwent both IVUS imaging and spiral computed tomography(CT).Six patients diagnosed as acute type B AIH by CT or IVUS composed the present study group.Results The study group consisted of five males and one female with mean age of 66 years old.All of them had chest or back pain.In one patient,CT omitted a localized AIH and an associated penetrating atherosclerotic ulcer(PAU),which were detected by IVUS.In another patient,CT mistaken a partly thrombosed false lumen as an AIH,whereas IVUS detected a subtle intimal tear and slow moving blood in the false lumen.In the four rest patients,both CT and IVUS made the diagnosis of AIH,however,IVUS detected three PAUs in three of them,only one of them was also detected by CT,and two of them escaped initial CT and were confirmed by follow up CT or magnetic resonance imaging.Conclusions IVUS imaging is a safe examination and has high accuracy in the diagnosis of AIH,particularly for diagnosing localized AIH,distinguishing AIH with thrombosed classic AD and detecting accompanied small PAUs. | Wei Hu Francois Schiele Nicolas Meneveau Marie-France Seronde Pierre Legalery Jean-Francois Bonneville Sidney Chocron Jean-Pierre Bassand | 2011 | Journal of Geriatric Cardiology2011，8，4： | 1 |
| 10 | The prognostic value of pro-B-Type natriuretic peptide in acute pulmonary embolism显示文摘 | Franck Verschuren Mathieu Bonnet Marie-Odile Benoit Damien Gruson Francis Zech Francis Couturaud Nicolas Meneveau Pierre-Marie Roy Marc Righini Guy Meyer Olivier Sanchez | 2013 | Thrombosis Research2013，，6： | 1 |
| 11 | Immediate versus delayed angioplasty in infarct-related arteries with TIMI III flow and ST segment recovery:a matched comparison in acute myocardial infarction patients显示文摘 | Nicolas Meneveau Marie France Séronde Vincent DescotesGenon | 2009 | Clinical Research in Cardiology2009，98，4： | 1 |
| 12 | 巨细胞病毒感染与冠状动脉支架内新生内膜组织量的关系显示文摘目的 探讨巨细胞病毒 (CMV)感染对冠状动脉支架内内膜增生的影响。方法 180例冠心病患者 ,于冠状动脉内支架置入术后 6个月复查冠状动脉造影和血管内超声检查。定量冠状动脉造影测定随访时的腔径减小 ,血管内超声测定支架内的平均新生内膜组织面积及其与支架横截面积之比。酶联免疫吸附法测定抗人CMVIgG抗体。 结果 CMV感染率达 5 1%。平均血管参考直径为 (2 94± 0 4 8)mm ,支架置入使平均最小腔内直径由 (0 99± 0 35 )mm上升至 (2 4 5± 0 4 2 )mm。 6个月随访时平均腔径减小 (0 74± 0 5 0 )mm ;平均新生内膜组织面积为 (3 8± 1 7)mm2 ,其与平均支架横截面积之比为 (4 5± 18) %。逐步多变量回归分析显示上述再狭窄指标与CMV感染无关联。结论 既往CMV感染与冠状动脉支架内新生内膜组织量无关。 | 刘品明 张少玲 Franois Schiele Nicolas Meneveau Jean-Pierre Bassand | 2003 | 中华心血管病杂志2003，31，11： | 0 |
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