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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | Nitrite accumulation by aeration controlled in sequencing batch reactors trea- ting domestic wastewater显示文摘 | Peng Y Z Chen Y Peng C Y | 2004 | Water Sci Technol2004，50，10： | 1 |
| 4 | PBDEs in sediments of the Beijiang River,China: levels,distribution,and influence of total organic carbon 显示文摘 | CHEN L G HUANG Y M PENG X C | 2009 | Chemosphere2009，76，2： | 1 |
| 5 | Influence of ORP variation, carbon source and nitrate concentration on denitrifying phosphorus removal by DPB sludge from dephanox process 显示文摘 | WANG Y Y PENG Y Z PENG C Y | 2004 | Wat Sci Tech2004，50，10： | 1 |
| 6 | 1-3-n-butylphth- alide improves cognitive impairment induced by intracerebroventricular infusion of amy- loid-beta peptide in rats 显示文摘 | Peng Y Xing C Xu S | 2009 | Eur J Pharmacol2009，621，13： | 1 |
| 7 | Size distribution of heavy metal aerosols in cooling and spray dryer system显示文摘 | WEY M Y YANG J T PENG C Y | 1999 | Journal of Environmental Engineering1999，125，11： | 1 |
| 8 | Synthesis by sol-gel process and characterization of LiCo02 cathode materials 显示文摘 | PENG Z S WAN C R T1ANG C Y | 1988 | J Power Sources1988，72，： | 1 |
| 9 | Kalman {iher decision systems for debris flow hazard assessment 显示文摘 | Lin J W Chen C W Peng C Y | 2012 | Nat Hazards2012，60，3： | 1 |
| 10 | Field emission properties of diamond- like carbon films annealed at different temperatures 显示文摘 | LI J J GU C Z PENG H Y | 2005 | Applied Surface Science2005，251，14： | 1 |
| 11 | Effect of rice bran on the production of different king oyster mushroom strains during bottle cultivation显示文摘 | Peng J T Lee C M Tsai Y E | 2000 | J A_gric Res China2000，49，： | 1 |
| 12 | Study on combined control of regenerative braking and antilock braking system for hy- brid electric vehicles 显示文摘 | Peng D Zhang Y Yin C L | 2008 | International Journal of Automo- tive Technology2008，9，6： | 1 |
| 13 | Mis-specification analysis of linear degradation models 显示文摘 | Peng C Y Tseng S T | 2009 | IEEE Transac-tions on Reliability2009，58，3： | 1 |
| 14 | Genetic variations in Tibetan populations and high-alti- tude adaptation at the Himalayas显示文摘 | Peng Y Yang Z Zhang H Cui C Qi X Luo X | 2011 | Mol Biol Evol2011，28，： | 1 |
| 15 | Nitrite accumulation by aeration controlled in sequencing batch reactors treating domestic wastewater显示文摘 | PENG Yong-zhen CHEN Ying PENG C Y | 2004 | Water Science and Technology:a Journal of the International Association on Water Pollution Research2004，50，10： | 1 |
| 16 | A green route to graphenepreparation显示文摘 | FAN X B PENG W C LI Y | 2008 | Adv Mater2008，20，23： | 1 |
| 17 | Detection and photodynamic therapy of inflamed atherosclerotic plaques in the carotid artery of rabbits显示文摘 | Peng C Li Y Liang H etal | 2011 | J Photochem Photobiol B2011，102，1： | 1 |
| 18 | Synopsis of thechinese species of Begonia ( Begoniaceae), with areappraisal of sectional delimitation 显示文摘 | SHUI Y M PENG C I WU C Y | 2002 | BotanicalBulletin of Academia Sinica2002，43，： | 1 |
| 19 | Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride显示文摘 | Lee C Y Peng W H Cheng H Y Chen F N Lai M T | 2006 | The American Journal of Chinese Medicine2006，34，3： | 1 |
| 20 | Functional case modelling for know- ledge-driven conceptual design显示文摘 | GU C HU J PENG Y | 2012 | Proceedings of the Institu- tion of Mechanical Engineers Part B Journal of Engineering Manufacture2012，226，4： | 1 |
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