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| 1 | Long‐standing remission of Crohn’s disease under imatinib therapy in a patient with Crohn’s disease显示文摘 | F.Magro C.Costa | 2006 | Inflamm Bowel Dis2006，，11： | 1 |
| 2 | Positron emission tomography and colorectal cancer显示文摘 | T. H. A.Arulampalam D. C.Costa M.Loizidou D.Visvikis P. J.Ell I.Taylor | 2002 | Br J Surg2002，，2： | 1 |
| 3 | Distinct physiological mechanisms underpin growth and rehydration of Hymenaea courbaril and Hymenaea stigonocarpa upon short-term exposure to drought stress显示文摘Plants hold biochemical and physiological mechanisms to withstand drought conditions.Generally,depending on water deficit interval,plant rehydration relies on how it can retain growth or a positive water balance—or rarely both.In this study,two species of Hymenaea,one from the Amazon and the other from the Brazilian Cerrado,were investigated for their physiological mechanism associated with growth rehydration upon short-term exposure to drought stress.Our findings demonstrate that Hymenaea courbaril tends to invest in nitrogen to the detriment of carbon compounds,-as it is limited by lower net photosynthesis-and adjust root growth to attenuate drought stress responses.In contrast,Hymenaea stigonocarpa takes advantage of higher water potential and a basal rate of lower net photosynthesis to support aboveground growth under such conditions.Hence,it is postulated that there are distinct ways of controlling water status and growth between H.courbaril and H.stigonocarpa,which are determined either by the ability of the species to keep net photosynthesis at low levels of water content or by favoring the accumulation of nitrogen compounds.Both mechanisms were effective with regards to water use efficiency and thus it is reasonable to suggest that strategies are not exclusive and may work under adverse conditions,as observed in Amazon and Brazilian Cerrado biomes.Query. | Luana M.Luz Ediane C.Alves Nariane Q.Vilhena Tamires B.Oliveira Zara G.B.Silva Joze M.N.Freitas Candido F.O.Neto Roberto C.L.Costa Lucas C.Costa | 2023 | Journal of Forestry Research2023，34，1： | 0 |
| 4 | EurBeST——在商业养蜂条件下测试抗螨蜜蜂的中试研究显示文摘根据官方报告,欧盟约有1600万群蜂、60万养蜂人,年生产蜂蜜价值近20亿欧元。除了直接生产蜂产品的价值外,蜜蜂还为农作物和野生植物授粉,有助于维护生物多样性和健康的农业生态系统。但是,农业生产的集约化、气候变化和全球化等导致一些蜂病的流行,给蜂群带来了巨大的压力。这其中包括寄生性的大蜂螨(Varroa destructor),如果不采取治疗措施,大多数蜂群在感染后一年内死亡。 | R.Buechler(文/图) A.Uzunov(文/图) C.Costa(文/图) M.Meixner(文/图) Y.Le Conte(文/图) F.Mondet(文/图) M.Kovacic(文/图) S.Andonov(文/图) N.L.Carreck(文/图) L.Dimitrov(文/图) B.Basso(文/图) M.Bienkowska(文/图) R.Dall’(文/图) Olio F.Hatjina(文/图) U.Wirtz(文/图) 陈超(文/图) | 2024 | 中国蜂业2024，75，1： | 0 |
| 5 | Structural optimization of patient-specific temporomandibular joint replacement implants for additive manufacturing:novel metrics for safety evaluation and biomechanical performance显示文摘Total temporomandibular joint(TMJ)replacement is recommended only when there is irreversible damage to the joint and no conservative treatment can provide functional improvements.Several stock and custom-made TMJ implants have been made available;however,retrospective and comparative studies were unable to find significant differences between the two types of solutions.The introduction of additive manufacturing(AM)techniques in medical practice allows for a greater freedom of design and a higher degree of device customisation.The combination of AM with structural optimisation may streamline development and provide the key for fabricating biomechanic ally enhanced TMJ implants.In this study,structural optimis ation techniques were applied to develop and numerically validate a patient-specific TMJ implant.The biomechanical behaviour of each intermediate TMJ design was assessed under four different nominal and maximum biting tasks using finite element analyses.In addition,a new set of metrics were proposed to compare each design regarding biomechanical performance and implant safety.The results suggest that 55-82%of the natural/intact strain patterns can be recovered with the finally selected TMJ implant.This represents an increase of 15%in biomechanical performance for incisor biting,15%for right molar biting,17%for left molar biting and a decrease of 2%for left group biting compared with the initial design.The results also suggest that load transfer at the proximal ramus reduces the implant’s impact on the mandible’s strain patterns.Finally,structural optimisation allows for a volume reduction of up to 44%with a minimum loss of implant safety and biomechanical performance. | Manuel Pinheiro Anouar Krairi Robin Willaert Maria C.Costa Wim Van Paepegem | 2022 | Bio-Design and Manufacturing2022，5，2： | 0 |
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