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| 1 | Methods of vascular control technique during liver resection:a comprehensive review显示文摘BACKGROUND:Significant hemorrhage together with blood transfusion increases postoperative morbidity and mortality of hepatic resection.Hepatic vascular occlusion is effective in minimizing bleeding during hepatic parenchymal transection.This article aimed to review the current role and status of various techniques of hepatic vascular occlusion during hepatic resection.DATA SOURCES:The relevant manuscripts were identified by searching MEDLINE,and PubMed for articles published between January 1980 and April 2010 using the keywords ' vascular control','vascular clamping','vascular exclusion' and 'hepatectomy'.Additional papers were identified by a manual search of the references from the key articles.RESULTS:One randomized controlled trial(RCT) and 5 RCTs showed intermittent Pringle maneuver and ischemic preconditioning followed by continuous Pringle maneuver were superior to continuous Pringle maneuver alone,respectively.Two RCTs compared the outcomes of hepatectomy with and without intermittent Pringle maneuver.One showed Pringle maneuver to be beneficial,while the other failed to show any benefit.One RCT showed that ischemic preconditioning had significantly less blood loss than using intermittent Pringle maneuver.Four RCTs evaluated the use of hemihepatic vascular occlusion.One RCT showed it had significantly less blood loss than Pringle maneuver,while the other 3 showed no significant difference.Only 1 RCT showed it had significantly less liver ischemic injury.No RCT had been carried out to assess segmental vascular occlusion.Two RCTs compared the outcomes of total hepatic vascular exclusion(THVE) and Pringle maneuver.One RCT showed THVE resulted in similar blood loss,but a higher postoperative complication.The other RCT showed less blood loss using THVE but the postoperative complication rate was similar.Both studies showed similar degree of liver ischemic injury.Only one RCT showed that selective hepatic vascular exclusion(SHVE) had less blood loss and liver ischemic injury than Pringle maneuver.CONCLUSION:Due to the great variations in these studies,it is difficult to draw a definitive conclusion on the best technique of hepatic vascular control. | Wan-Yee Lau Eric C.H.Lai Stephanie H.Y.Lau | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，5： | 27 |
| 2 | The current role of neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for hepatocellular carcinoma:a systematic review显示文摘BACKGROUND:Following curative treatment for hepato-cellular carcinoma(HCC),50%-90% of postoperative death is due to recurrent disease.Intra-hepatic recurrence is frequently the only site of recurrence.Thus,any neoadjuvant or adjuvant therapy,which can decrease or delay the incidence of intra-hepatic recurrence,or any cancer chemoprevention which can prevent a new HCC from developing in the liver remnant,will improve the results of liver resection.This article systematically reviewed the current evidence of neoadjuvant,adjuvant, and chemoprevention in partial hepatectomy of HCC. DATA SOURCES:Studies were identified by searching MEDLINE and PubMed databases for articles from January 1990 to November 2008 using the keywords 'hepatocellular carcinoma','hepatectomy','adjuvant therapy','neoadjuvant therapy',and'regional therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS:Neoadjuvant transarterial chemoembolization or adjuvant regional transarterial chemotherapy± embolization+systemic chemotherapy did not add benefit. Both adjuvant transarterial radioembolization with 131 I-lipiodol and adjuvant systemic interferon showed promising results.However,there were only a limited number of such studies.CONCLUSIONS:Further randomized controlled studies need to be carried out.Currently,there is no consensus on a standard neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for HCC. | Wan-Yee Lau Eric C.H.Lai Stephanie H.Y.Lau | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 24 |
| 3 | Classification of iatrogenic bile duct injury显示文摘BACKGROUND:Iatrogenic bile duct injury continues to be an important clinical problem,resulting in serious morbidity,and occasional mortality,to patients.The ease of management,operative risk,and outcome of bile duct injuries vary considerably,and are highly dependent on the type of injury and its location.This article reviews the various classification systems of bile duct injury. DATA SOURCES:A Medline,PubMed database search was performed to identify relevant articles using the Keywords 'bile duct injury','cholecystectomy',and'classification'. Additional papers were identified by a manual search of the references from the key articles. RESULTS:Traditionally,biliary injuries have been classified using the Bismuth's classification.This classification, which originated from the era of open surgery,is intended to help the surgeons to choose the appropriate technique for the repair,and it has a good correlation with the final outcome after surgical repair.However,the Bismuth's classification does not encompass the whole spectrum of injuries that are possible.Bile duct injury during laparoscopic cholecystectomy tends to be more severe than those with open cholecystectomy.Strasberg’s classification made Bismuth’s classification much more comprehensive by including various other types of extrahepatic bile duct injuries.Our group,Bergman et al,Neuhaus et al,Csendes et al,and Stewart et al have also proposed other classification systems to complement the Bismuth's classification. CONCLUSIONS:None of the classification system is universally accepted as each has its own limitation.Hopefully, a universally accepted comprehensive classification system will be published in the near future. | Wan-Yee Lau Eric C.H.Lai | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，5： | 6 |
| 4 | Development and controversies of adjuvant therapy for pancreatic cancer显示文摘BACKGROUND:Pancreatic cancer is an aggressive malignancy with a dismal prognosis. Radical surgery provides the only chance for a cure with a 5-year survival rate of 7%-25%. An effective adjuvant therapy is urgently needed to improve the surgical outcome. This review describes the current status of adjuvant therapy for pancreatic cancer, and highlights its controversies. DATA SOURCES: A Medline database search was performed to identify relevant articles using the keywords 'pancreatic neoplasm', and 'adjuvant therapy'. Additional papers were identified by a manual search of the references from the key articles. RESULTS: Eight prospective randomized controlled trials (RCTs) on the use of adjuvant chemotherapy and chemoradiation for pancreatic cancer could be identified. The results for adjuvant regimens based on systemic 5-fluorouracil with or without external radiotherapy were conflicting. The recent two RCTs on gemcitabine based regimen gave promising results. CONCLUSIONS: Based on the available data, no standard adjuvant therapy for pancreatic cancer can be established yet. The best adjuvant regimen remains to be determined in large- scale RCTs. Future trials should use a gemcitabine based regimen. | Wan-Yee Lau Eric C.H.Lai | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 5 |
| 5 | A step forward in laparoscopic hepatectomy:comments on“Expert Consensus on Laparoscopic Hepatectomy(2013 Version)by National Hepatic Surgery Group,Society of Surgery,Chinese Medical Association”显示文摘I read with great interest the consensus and guideline of laparoscopic hepatectomy,which was originated from the experts in China[1].This is a significant step forward in minimally invasive liver surgery.The development of minimally invasive liver surgery over the last 2 decades has a great impact on the surgical practice in China,and the other parts of the world.The potential advantages of laparoscopic hepatectomy are those of minimal access surgery(Table 1). | Eric C.H.Lai | 2013 | Frontiers of Medicine2013，7，4： | 1 |
| 6 | 查看详情显示文摘 | L.Huang Y.C.Lai K.Park X.G.Wang C.H.Lai and R.A.Gatenby | | 0，，： | 1 |
| 7 | Progress of Pattern Dynamics in Plasma Waves显示文摘This paper is concerned with the pattern dynamics of the generalized nonlinear Schrodinger equations(NSEs)relatedwith various nonlinear physical problems in plasmas.Our theoretical and numerical results show that the higher-order nonlinear effects,acting as a Hamiltonian perturbation,break down the NSE integrability and lead to chaotic behaviors.Correspondingly,coherent structures are destroyed and replaced by complex patterns.Homoclinic orbit crossings in the phase space and stochastic partition of energy in Fourier modes show typical characteristics of the stochastic motion.Our investigations show that nonlinear phenomena,such as wave turbulence and laser filamentation,are associated with the homoclinic chaos.In particular,we found that the unstable manifolds W(u)possessing the hyperbolic fixed point correspond to an initial phase θ=45° and 225° ,and the stable manifolds W(s)correspond toθ=135° and 315° . | B.Qiao C.T.Zhou X.T.He C.H.Lai | 2008 | Communications in Computational Physics2008，4，10： | 0 |
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