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| 1 | The cardiovascular response to insertion of the intubating laryngeal mask airway显示文摘 | A.Choyce M. S.Avidan A.Harvey C.Patel C.Timberlake K.Sarang L.Tilbrook | 2002 | Anaesthesia2002，，： | 2 |
| 2 | Identification of binding interactions between myeloperoxidase and its antibody using SERS显示文摘Surface Enhanced Raman Spectroscopy(SERS) is a widely used spectroscopic method that can dramatically increase the sensitivity of Raman spectroscopy and has demonstrated significant benefit in the identification of biological molecules. We report the use of SERS in differentiating the bound immunocomplex of myeloperoxidase(MPO) and its antibody from the unbound complex and its individual components. The SERS signal was enabled by gold nanoparticles attached to MPO, p Ab and their immunocomplex at an excitation wavelength of 785 nm. The obtained SERS spectrum of MPO is in agreement with previous literature. Comparative SERS spectrum analysis of MPO, p Ab, and their immunocomplex reveals the significant peak shifts and intensity variations caused by the conformational changes due to the immunocomplex formation. Several key areas have been identified which correspond to specific amino acids being shielded from undergoing resonance while new amino acid residues are made visible in the SERS spectrum of the immunocomplex and could be a result of conformational binding. Our work demonstrates the capability of SERS to identify binding events and differentiate an immunocomplex from its unbound components with direct applications in biosensors. | E.S.Papazoglou S.Babu S.Mohapatra D.R.Hansberry C.Patel | 2010 | Nano-Micro Letters2010，2，2： | 1 |
| 3 | LC-MS/MS assay for olanzapine in human plasma and its application to a bioequivalence study显示文摘This paper describes a selective and sensitive assay for the determination of olanzapine(OLZ)in human plasma based on liquid chromatography-tandem mass spectrometry(LC-MS/MS).The analyte and quetiapine as internal standard(IS)were extracted from 200μL plasma via solid phase extraction on Waters Oasis HLB cartridges.Chromatographic separation was achieved on an ACE 5C18-300 column(100 mm × 4.6 mm,5μm)under isocratic conditions in a run time of 3.5 min.Mass spectrometric detection involved electrospray ionization in the positive ion mode followed by multiple reaction monitoring(MRM)of the transitions at m/z 313/256 for OLZ and m/z 384/253 for the IS.The assay was linear in the range 0.10-40.0 ng/mL with a lower limit of quantitation and limit of detection of 0.10 and 0.012 ng/mL,respectively.Intra-and inter-day precision(as coefficient of variation)and relative recovery were<5.0% and>90%,respectively.The method was succesfully applied to a bioequivalence study of 5 and 10 mg OLZ disintegrating tablets in 40 healthy Indian males with reproducibility by incurred sample reanalysis in the range-7.43 to 8.07%. | Dinesh S.Patel Naveen Sharma Mukesh C.Patel Bhavin N.Patel Pranav S.Shrivastav Mallika Sanyal | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 1 |
| 4 | Migration of intra-aortic balloon pump causing obstruction of the superior mesenteric artery显示文摘Axillary intra-aortic balloon pump(IABP)used has increased in the recent few years after UNOs allocation system changes.IABP’s design and counterpulsation mechanism is highly regarded for its safety profile,simplicity and relative ease in management and care.However,despite continuous innovative efforts,the potential for complications still exists.The Benchmark registry is widely regarded as the tool for monitoring the evolving practice of IABP.The most common complications reported are balloon perforation,bleeding,migration,limb ischemia.Despite continuous innovative efforts,the potential for complications still exists. | Sharan Malkani Jose Ruiz Smruti Desai Smit Paghdar Parag C.Patel Juan Carlos Leoni Moreno Melissa Lyle Maedeh Ganji Daniel Yip Rohan M.Goswami | 2022 | Journal of Geriatric Cardiology2022，19，11： | 0 |
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