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| 1 | LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodeling显示文摘Lipoprotein receptor-related protein 6(LRP6) plays a critical role in skeletal development and homeostasis in adults. However, the role of LRP6 in mesenchymal stem cells(MSCs), skeletal stem cells that give rise to osteoblastic lineage, is unknown. In this study, we generated mice lacking LRP6 expression specifically in nestin1MSCs by crossing nestin-Cre mice with LRP6floxmice and investigated the functional changes of bone marrow MSCs and skeletal alterations. Mice with LRP6 deletion in nestin1cells demonstrated reductions in body weight and body length at 1 and 3 months of age. Bone architecture measured by microCT(mCT) showed a significant reduction in bone mass in both trabecular and cortical bone of homozygous and heterozygous LRP6mutant mice. A dramatic reduction in the numbers of osteoblasts but much less significant reduction in the numbers of osteoclasts was observed in the mutant mice. Osterix1osteoprogenitors and osteocalcin1osteoblasts significantly reduced at the secondary spongiosa area, but only moderately decreased at the primary spongiosa area in mutant mice. Bone marrow MSCs from the mutant mice showed decreased colony forming, cell viability and cell proliferation. Thus, LRP6 in bone marrow MSCs is essential for their survival and proliferation, and therefore, is a key positive regulator for bone formation during skeletal growth and remodeling. | Changjun Li Bart O Williams Xu Cao Mei Wan | 2014 | Bone Research2014，2，1： | 6 |
| 2 | Dispersal in the Glanville fritillary butterfly in fragmented versus continuous landscapes:comparison between three methods 显示文摘 | Wang R Ovaskainen O Cao Y D | 2011 | Ecological Entomology2011，36，： | 1 |
| 3 | Expression of angiostation eDNA in a murine fibrosarcoma suppresses primary tumor growth and produce long-term doumancy of metastases显示文摘 | Cao Y H O'Reilly M S Marashall B | 1998 | J Clin Invest1998，101，5： | 1 |
| 4 | Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases显示文摘 | Cao Y H O'Reilly M S Marshall B | 1998 | J Chin Ivest1998，101，： | 1 |
| 5 | Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension显示文摘 | Cao Y Li H Mu FT Ebisui O Funder JW Liu JP | 2002 | FASEB2002，16，1： | 1 |
| 6 | Variations in the fermentation characteristics of alfalfa silage of differentharvest times as treated with fermented juice of epiphytic lactic acid bacteria显示文摘 | CAO L m MASAKAZU G MITSUAKI O | 2002 | Grassland Science2002，47，6： | 1 |
| 7 | Telomerase activation causes vascular smooth muscle cell proliferation in genet- ic hypertension显示文摘 | Cao Y Li H Mu FT Ebisui O Funder JW Hu JP | 2002 | FASEB J2002，16，1： | 1 |
| 8 | Nanostructured oxides by highenergy ball milling technique:application as gas sensing materials显示文摘 | TAN O K CAO W HUA Y | 2004 | Solid State Ionics2004，172，： | 1 |
| 9 | Where do Chinese scientists pub- lish their research in environmental science and technology? 显示文摘 | Zhu Y O'Connor P Cao J | 2006 | Environ Pollution2006，，1： | 1 |
| 10 | Effect of interface on the properties of fiber-reinforced ceramics显示文摘 | CAO H C BISCHOFF E SBAIZERO O | | 0，，09： | 1 |
| 11 | DLC-1 is deleted in primary hepatocellular carcinoma and exert inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1显示文摘 | Ng I O Liang Z-D Cao L | 2000 | Cancer Res2000，60，： | 1 |
| 12 | Advance in Powder Metallurgy显示文摘 | Cao M Y Rhee B O Chung C I | 1998 | Metal Powder Industries Federation1998，2，： | 1 |
| 13 | A power efficient 26-GHz 32:1 static frequency divider in 130-nm bulk CMOS显示文摘 | Changhua Cao O K K | 2005 | IEEE Microwave and Wireless Components Letters2005，15，11： | 1 |
| 14 | An optimized cost -sensitive SVM for imbalanced data learning显示文摘 | Cao P Zhao D Zaiane O | 2013 | Lecture Notes in Computer Science2013，，： | 1 |
| 15 | Variations in the fer- mentation characteristics of alfalfa silage of different harvest times as treated with fermented juice of epiphytic lactic acid bacteria显示文摘 | Cao L M Masakazu G Mitsuaki O | 2002 | Grassland Science2002，47，6： | 1 |
| 16 | Sensor network localization with imprecise distances 显示文摘 | Cao M Anderson B D O Morse A S | 2006 | Systems & Control Letters2006，55，11： | 1 |
| 17 | Study on grade judgment of fruit vegetables using machine vision(Part 3)显示文摘 | CAO O NAGATA M | 1997 | Journal of Society of High Technology in Agriculture1997，9，1： | 1 |
| 18 | Surface wrinkling of mucosa induced by volumetric growth:theory,simulation and experiment 显示文摘 | Li B Cao Y P Feng X O Gao H | 2011 | Journal of the Mechanics and Physics of Solids2011，59，： | 1 |
| 19 | Antioxidant capacity as influenced by total phenolic and anthocyanin content maturity and variety of Vaccinum species 显示文摘 | Prior R L Cao G Martin A Sofic E McEwen J O' Brien C Lischner N Ehlenfeldt M Kah W Krewer G Mainland C M | 1998 | Journal of Agricultural and Food Chemistry1998，46，： | 1 |
| 20 | Formation control using range-only measurements 显示文摘 | Cao M Yu C B Anderson B D O | 2011 | Automatica2011，47，4： | 1 |
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