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| 1 | Introducing an enhanced recovery after surgery program in colorectal surgery:A single center experience显示文摘AIM:To study the implementation of an enhanced recovery after surgery(ERAS)program at a large University Hospital from'pilot study'to'standard of care'.METHODS:The study was designed as a prospective single centre cohort study.A prospective evaluation of compliance to a protocol based on full application of all ERAS principles,through the progressive steps of its implementation,was performed.Results achieved in the initial pilot study conducted by a dedicated team(n=47)were compared to those achieved in the shared protocol phase(n=143)three years later.Outcomes were length of postoperative hospital stay,readmission rate,compliance to the protocol and morbidity.Primary endpoint was the description of the results and the identification of critical issues of large scale implementation of an ERAS program in colorectal surgery emerged in the experience of a single center.Secondary endpoint was the identification of interventions that have been proven to be effective for facilitating the transition from traditional care pathways to a multimodal management protocol according to ERAS principles in colorectal surgery at a single center.RESULTS:During the initial pilot study(March 2009 to December 2010;47 patients)conducted by a dedicated multidisciplinary team,compliance to the items of ERAS protocol was 93%,with a median length of hospital stay(LOS)of 3 d.Early anastomotic fistulas were observed in 2 cases(4.2%),which required reoperation(Clavien-Dindo gradeⅢb).None of the patients had been discharged before the onset of the complication,which could therefore receive prompt treatment.There were also four(8.5%)minor complications(ClavienDindo gradeⅡ).Thirty days readmission rate was 4%.Perioperative mortality was nil.After implementation of the protocol throughout the Hospital in unselected patients(May 2012 to December 2012;147 patients)compliance was 74%,with a median LOS of 6 d.Early anastomotic fistulas were observed in 11 cases(7.7%),5(3.5%)of which required reoperation(Clavien-Dindo gradeⅢb).Two early anastomotic fistulas were treated by radiologic/endoscopic manoeuvres and 4 were treated conservatively.There were also 36(25.2%)minor complications,21(14.7%)of which were Clavien-Dindo gradeⅡand 15(10.5%)of which were Clavien-Dindo gradeⅠ.Only two patients whose course was adversely affected by the development of an anastomotic leak had been discharged before the onset of the complication itself,requiring readmission.Readmission rate within 30 d was 4%.Perioperative mortality was 1%.CONCLUSION:Our results confirm that introduction of an ERAS protocol for colorectal surgery allows quickerpostoperative recovery and shortens the length of stay compared to historical series. | Stefano Bona Mattia Molteni Riccardo Rosati Ugo Elmore Pietro Bagnoli Roberta Monzani Monica Caravaca Marco Montorsi | 2014 | World Journal of Gastroenterology2014，20，46： | 30 |
| 2 | Do inflammatory markers add predictive information of death beyond that provided by age and comorbidity in chronic renal failure patients显示文摘 | Caravaca F Martin MV Barroso S | 2006 | Nephrel Dial Transplant2006，21，： | 1 |
| 3 | Changes in physical and biological soil quality indicators in a tropical crop system (Havana,Cuba) in response to different agroecological management practices 显示文摘 | CARAVACA F ALGUACIL M M ROLDAN A | 2003 | Environment Management2003，32，5： | 1 |
| 4 | Use of Micro-biological indicators for evaluating success in soil resttionafter revegetation of a mining area under subtropical cotions显示文摘 | Izquierdo I Caravaca F Alguacil M M | 2005 | Applied Soil Ecology2005，30，： | 1 |
| 5 | Cross-reactivity between Platanus pollen and vegetables显示文摘 | Caravaca F Guillen F et al | 2002 | AUergy2002，57，： | 1 |
| 6 | Do inflammatory markers add predictive information of death beyond that provided by age and comorbidity in chronic renal failure patients显示文摘 | Francisco Caravaca Maria Victoria Martin Sergio Barroso | 2006 | Nephrol Dial Transplant2006，21，： | 1 |
| 7 | Comparing the effe-ctiveness of mycorrhizal inoculation and amendment with sugar beet, rock phosphate and Aspergillus niger to enhance field performance of the leguminous shrub Dorycnium pentaphyllum L 显示文摘 | Caravaca F Alguacil M M Azcón R | 2004 | Applied Soil Ecology2004，25，： | 1 |
| 8 | No-tillage,crop residue additions,and legume cover cropping effects on soil quality characteristics under maize in Patzcuaro watershed (Mexico)显示文摘 | Roldan A Caravaca F Hernandez M T | 2003 | Soil and Tillage Research2003，72，1： | 1 |
| 9 | Synergistic extraction of gold (I) cyanide with the primary amine Primene JMT and the phosphine oxide Cya- nex 921 显示文摘 | Alguacil F J Caravaca C | 1996 | Hydrometallurgy1996，42，2： | 1 |
| 10 | Insulin resistance in chronic kidney disease: its clinical characteristics and prognosis significance 显示文摘 | Caravaca F Cerezo I Macias R | 2010 | Nefrologia2010，30，6： | 1 |
| 11 | Direct carotid cavernous fistulas:endovas- cular treatment using a detachable ballon显示文摘 | FAGES CARAVACA E M TEMBL FERRAIRO J I LAGO MARTIN A | 2001 | Rev Neurol2001，33，6： | 1 |
| 12 | Use of microbi- ological indicators for evaluating success in soil restoration after revegetation of a mining area under subtropical condi- tions显示文摘 | Izquierdo I Caravaca F Alguacil M M | 2005 | Applied Soil Ecology2005，30，1： | 1 |
| 13 | Insulin resistance in chro-nic kidney disease : its clinical characteristics and prognosis signif-icance 显示文摘 | Caravaca F Cerezo I Macias R | 2010 | Nefrologia2010，30，6： | 1 |
| 14 | Aggregate stability and carbon characteristics of particle-size fractions in cultivated and forested soils of semiarid Spain 显示文摘 | CARAVACA F LAX A ALBALADEJO J | 2004 | Soil & Tillage Research2004，78，： | 1 |
| 15 | Assessing changes in physical and biological properties in a soil contaminated by oil sludge under semiarid Mediterranean conditions显示文摘 | Caravaca F Caravaca F Rolda'n A | 2003 | Geoderma2003，117，： | 1 |
| 16 | Improvement of rhizosphere aggregate stability of afforested semiarid plant species subjected to mycorrhizal inoculation and compost addition 显示文摘 | CARAVACA F HERNANDEZ T GARCIA C | 2002 | Geoderma2002，108，12： | 1 |
| 17 | Soil aggregate stability and organic matter in clay and fine silt fractions in urban refuseamended semiarid soils 显示文摘 | CARAVACA F LAX A ALBALADEJO J | 2001 | Soil Science Society of America Journal2001，65，4： | 1 |
| 18 | Do inflammatory markers add predictive information, of death beyond that provided by age and comorbidity in chronic renal failure patients显示文摘 | Caravaca F Martin MV Barroso S | 2006 | Nephrol Dial Transplant2006，21，： | 1 |
| 19 | α-酪蛋白和κ-酪蛋白基因型对Murciano-Granadina山羊乳成分的影响显示文摘研究结果表明,羊的α-酪蛋白的基因多态性影响乳的品质;但是κ-酪蛋白的基因型是否影响乳的组成还知之甚少。并且α-酪蛋白和K-酪蛋白基因型的交互作用也研究较少。因此,本试验选择89头Murciano-Granadina山羊旨在研究α-酪蛋白和κ-酪蛋白基因型与乳品质之间的关系。在Murciano-Granadina山羊316 d的泌乳期内,每隔一周测定一次乳产量、总蛋白、乳脂肪、非脂固形物、乳糖、αs1-酪蛋白、αs2-酪蛋白等的含量。结果表明,αs1-酪蛋白和κ-酪蛋白基因型之间没有交互作用。与κ-酪蛋白的AA基因型相比,κ-酪蛋白的AB和BB基因型显著影响乳中总蛋白和蛋白质分数。并且试验结果与法国在山羊品种上的试验结果不同,本试验结果证明,αs1基因型不影响乳蛋白、酪蛋白和脂肪的含量。生产上当考虑山羊乳的成分时,应对κ-酪蛋白基因型引起足够的重视。 | Caravaca F 张养东 | 2009 | 中国畜牧兽医2009，36，8： | 1 |
| 20 | No-tillage,crop residue additions,and legume cover cropping effects on soil quality characteristics under maize in Patzcuaro watershed(Mexico)显示文摘 | Roldan A Caravaca F Hernandez M T | 2003 | Soil & Tillage Research2003，72，： | 1 |
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