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3篇 您的检索式：作者名="Maria Victoria Martin"

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		题名	作者	年代	出处	被引量
	1	Do inflammatory markers add predictive information of death beyond that provided by age and comorbidity in chronic renal failure patients显示文摘	Francisco Caravaca Maria Victoria Martin Sergio Barroso	2006	Nephrol Dial Transplant2006，21，：	1
	2	Daubechies wavelet beam and plate finite elements 显示文摘	Lilliam Alvarez Diaz Martin Maria T Victoria Vampa	2009	Finite Elements in Analysis and Design2009，45，3：	1
	3	Physiological and druggable skipping of immunoglobulin variable exons in plasma cells显示文摘The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)pre-mRNAs.We recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after nonsense-associated altered splicing(NAS)events.Remarkably,the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell(PC)lifespan.Many questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion(TIE-)checkpoint and its restriction to the ultimate stage of B-cell differentiation.To address these issues,we evaluated the extent of NAS of Ig pre-mRNAs using an Ig heavy chain(IgH)knock-in model that allows for uncoupling of V exon skipping from TIE-induced apoptosis.We found high levels of V exon skipping in PCs compared with B cells,and this skipping was correlated with a biallelic boost in IgH transcription during PC differentiation.Chromatin analysis further revealed that the skipped V exon turned into a pseudo-intron.Finally,we showed that hypertranscription of Ig genes facilitated V exon skipping upon passive administration of splice-switching antisense oligonucleotides(ASOs).Thus,V exon skipping is coupled to transcription and increases as PC differentiation proceeds,likely explaining the late occurrence of the TIE-checkpoint and opening new avenues for ASO-mediated strategies in PC disorders.	Mohamad Omar Ashi Nivine Srour Jean-Marie Lambert Anne Marchalot Ophelie Martin Sandrine Le Noir Eric Pinaud Maria Victoria Ayala Christophe Sirac Jerome Sauliere Jerome Moreaux Michel Cogne Laurent Delpy	2019	Cellular & Molecular Immunology2019，16，10：	0

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