|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Driving gene-engineered T cell immunotherapy of cancer显示文摘妄想的抗原受体(汽车) 设计基因的 T 房间治疗保持潜力与终末期癌在病人的生活有有意义的差别。为十年,癌症治疗基于生物物理的参数,与到 debulk 的外科的切除术,由放射和化疗列在后面指向很快成长的肿瘤房间,当时主要 sparing 静止正常纸巾。一突破与 allogeneic 骨头髓发生了与白血病为病人移植,它提供了一有时药品治疗。为稳固的肿瘤的采纳房间治疗的地与发现被建立渗入肿瘤的淋巴细胞能与变形黑瘤被扩展并且使用到对待和甚至痊愈病人。肿瘤特定的 T 房间受体(TCR ) 被识别并且设计了进耐心的外部血淋巴细胞,它也被发现治疗肿瘤。然而,这些被耐心的 HLA 限制限制。紧随来汽车的产生,把抗体的优美识别与一个 T 房间的受动器功能相结合。为与先进 B 房间恶意的多重表格对待病人的指向 CD19 的汽车的来临取得了大成功,与多达 95% 反应率。然而,到稳固的肿瘤的适用的汽车治疗刚开始了,但是已经,某些因素被弄明白:肿瘤目标具有最大的重要性让临床医生不做伤害;并且稳固的肿瘤与 hematologic 相比对汽车治疗不同地作出回应。这里,我们考察临床的设计基因的 T 房间免疫疗法,它的成功,挑战,和未来的状态。 | Laura A Johnson Carl H June | 2017 | Cell Research2017，27，1： | 37 |
| 2 | Nat Methods:新型计算方法或能更加精准地分析基因表达状况显示文摘日前,一项刊登在国际杂志NaCre Methods上的研究报告中,来自美国卡内基梅隆大学等机构的研究人员通过研究开发了一种新型的计算方法,该方法能够有效改善对基因表达分析的准确性。研究人员或有望利用该方法来诊断并且监测癌症。同时或许也能够促进基础生物学的研究进展。 | Rob Patro Geet Duggal Michael I Love Rafael A Irizarry Michael I Love Rafael A Irizarry Carl Kingsford | 2017 | 现代生物医学进展2017，17，11： | 30 |
| 3 | Cardiac rehabilitation and exercise therapy in the elderly: Should we invest in the aged?显示文摘冠的心疾病(CHD ) 是世界范围的死亡的领先的原因并且在病人之中变得逐渐地流行 65 岁以上。老病人在为复杂并发症的更高的风险并且在一个心血管的事件以后加速物理 deconditioning,特别与他们的更年轻的对应物相比。最后几十年是到与 CHD 在病人之中在死亡,锻练能力,心理风险因素,发炎,和肥胖上表明了心脏的康复(CR ) 和锻练治疗的有益的效果的多重研究的厕所。不幸地,这个领域里的可得到的数据的重要部分与更年轻的病人相关。可行解释是更老的病人在为以病人开始并且延长到医生的多重原因的这些节目是非常未被充分代表的。在这篇文章,我们将考察 CR 节目的好处在之中老,以及一些妨碍他们的参予的障碍。 | Arthur R Menezes Carl J Lavie Richard V Milani Ross A Arena Timothy S Church | 2012 | Journal of Geriatric Cardiology2012，9，1： | 25 |
| 4 | 低温加氢催化剂的设计:理论与实践(英文)显示文摘简要总结了我们在C=C及C=O双键低温加氢双金属催化剂方面的最新研究成果.首先,我们以环己烯加氢为探针反应,证明了平行使用多种研究手段的重要性,包括单晶表面的基础研究与DFT计算,多晶表面的合成与表征,负载型催化剂的制备与性能测试等.其次,总结了双金属催化剂在其他加氢反应,如丙烯醛C=O双键的选择性加氢,苯的低温加氢,以及乙炔的选择性加氢等反应中的应用.最后,讨论了利用金属碳化物代替贵金属Pt以减少双金属催化剂中Pt用量的可能性. | 陈经广 齐随涛 HUMBERT Michael P MENNING Carl A 朱月香 | 2010 | 物理化学学报2010，26，4： | 6 |
| 5 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 6 | Pesticide food safety standards as companions to tolerances and maximum residue limits显示文摘Allowable levels for pesticide residues in foods,known as tolerances in the US and as maximum residue limits(MRLs) in much of the world,are widely yet inappropriately perceived as levels of safety concern. A novel approach to develop scientifically defensible levels of safety concern is presented and an example to determine acute and chronic pesticide food safety standard(PFSS) levels for the fungicide captan on strawberries is provided. Using this approach,the chronic PFSS level for captan on strawberries was determined to be 2 000 mg kg–1 and the acute PFSS level was determined to be 250 mg kg–1. Both levels are far above the existing tolerance and MRLs that commonly range from 3 to 20 mg kg–1,and provide evidence that captan residues detected at levels greater than the tolerance or MRLs are not of acute or chronic health concern even though they represent violative residues. The benefits of developing the PFSS approach to serve as a companion to existing tolerances/MRLs include a greater understanding concerning the health significance,if any,from exposure to violative pesticide residues. In addition,the PFSS approach can be universally applied to all potential pesticide residues on all food commodities,can be modified by specific jurisdictions to take into account differences in food consumption practices,and can help prioritize food residue monitoring by identifying the pesticide/commodity combinations of the greatest potential food safety concern and guiding development of field level analytical methods to detect pesticide residues on prioritized pesticide/commodity combinations. | Carl K Winter Elizabeth A Jara | 2015 | Journal of Integrative Agriculture2015，14，11： | 3 |
| 7 | Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis显示文摘 | Marlene Dominguez Rosa Miquel Jordi Colmenero Montserrat Moreno Joan–Carles García–Pagán Jaime Bosch Vicente Arroyo Pere Ginès Juan Caballería Ramón Bataller | 2009 | Gastroenterology2009，，5： | 3 |
| 8 | By-products of plant food processing as a source of functional compounds — recent developments显示文摘 | A Schieber F.C Stintzing R Carle | 2002 | Trends in Food Science & Technology2002，，11： | 2 |
| 9 | Probable involvement of thaxtomins A in pathogenicity of Streptomyces scabies on seedlings显示文摘 | LEINER R H FRY B A CARLING D E | 1996 | Phytopathology1996，86，： | 2 |
| 10 | Evolution of the management of laryngeal cancer显示文摘 | Genden EM Ferlito A Carl E | 2007 | Silver Oral Oncology2007，43，： | 1 |
| 11 | Lipid peroxidation in pregnancy: new perspectives on preeclampsia显示文摘 | Carl A Hubel James M | 1989 | J Obstet Gynecol1989，161，4： | 1 |
| 12 | Acta Mater显示文摘 | Carling K M Carter E A | 2007 | 2007,55: 27912007，55，： | 1 |
| 13 | New developments in nucleus pulpous replacement technology显示文摘 | CARL A L LEDET E YUAN H | 2004 | Spine2004，4，16： | 1 |
| 14 | Construction of sand shinnery oak communities of the Llano Estacado: Animal disturbances, plant community structure, and restoration显示文摘 | Shivcharn S Dhillion Mark A McGinley Carl F Friese | 1994 | Restoration Ecology1994，2，1： | 1 |
| 15 | Burst fractures of the fifth lumbar vertebra显示文摘 | Mick CA Carl A Seehs B | 1993 | Spine1993，18，： | 1 |
| 16 | Effects of medium composition on the morphology and function of rat hepatocytes cultured as spheroids and monolyers显示文摘 | Geraldine A Carl W Elisabeth G | 2001 | Int Vitro Cell Dev Biol2001，37，： | 1 |
| 17 | Quantitative determination of carotene stereoisomers in carrot juices and vitamin supplemented (ATBC) drinks显示文摘 | Marx M Schieber A Carle R | 2000 | Food Chemistry2000，70，： | 1 |
| 18 | New Percutaneous Access Method for Minimally Invasive Anterior Lumbosacral Surgery显示文摘 | CRAGG A CARL A CASTENEDA F | 2004 | J Spinal Disord Tech2004，17，1： | 1 |
| 19 | Calculation of the roal of coal constituent elements on the enhanced vaporization of silica显示文摘 | NAGELBERG A S MAR R W CARLING R W | 1985 | High Temperature Science1985，19，1： | 1 |
| 20 | Analysis of 77000 canine uroliths 显示文摘 | Carl A Jody P David J etal | 1999 | Vet Clin Nor Am: Smal Anita Prac1999，29，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员