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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 3 | High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease显示文摘AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood culture.RESULTS:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot assays.All 69 cultures were negative by acid-fast Ziehl-Neelsen staining.Viable MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD controls.No association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide polymorphisms.CONCLUSION:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD patients.However,MAP spheroplasts were only found in CD patients. | Juan L Mendoza Amparo San-Pedro Esther Culebras Raquel Cíes Carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre Juan J Picazo Manuel Díaz-Rubio | 2010 | World Journal of Gastroenterology2010，16，36： | 5 |
| 4 | Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis 显示文摘 | Graceffa D Amorosi B Maiani E Bonifati C Cbi menti MS Perrieone R Di Carlo A | 2013 | Arthritis2013，，95： | 1 |
| 5 | Multiresidue herbicide analysis in soil: subcritical water extraction with an on-line sorbent trap 显示文摘 | Carlo C Giuseppe D Ascenz O | 1999 | Anal Commun1999，71，： | 1 |
| 6 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | Michael T R James J C Carlo J D L | 1993 | Physica D1993，65，2： | 1 |
| 7 | Impact of ovine whey protein concentrates and clarification by products on the yield and quality of whey cheese显示文摘 | CARLOS D P OLGA D ANGEL C | 2007 | Food Technology Biotechnology2007，4，2： | 1 |
| 8 | 16S rRNA gene sequence analysis of Photobacterium damselae and nested PCR method for rapid detection of the causative agent of fish pasteruellosis显示文摘 | CARLOS R O MATTHEW D C ALICIA E T | 1999 | Appl Environ Microbiol1999，65，7： | 1 |
| 9 | pH as a key factor in the competition between glycogen-accumulating organisms and phosphorus-accumulating organisms显示文摘 | Filipe Carlos D M Daigger Glen GradyT C P Leslie | 2001 | Water Environment Research2001，73，2： | 1 |
| 10 | Inversion of two level circulant matrices over Zp显示文摘 | CARLO J A GIANNA M D C GIOVANNI M | 2003 | Linear Algebra and Its Applications2003，366，： | 1 |
| 11 | Rheological and Physico-Chemical Characterization of Prebiotic Microfiltered Fer- mented milk显示文摘 | JANAINA D SCHWINDEN P CARLOS C P J | 2010 | Journal of Food Engineering2010，99，2： | 1 |
| 12 | Nitric oxide:properties and therapeutic use显示文摘 | Ricardo de L B Carlos Roque D C Marcelo N M | 2005 | Quím Nova2005，28，6： | 1 |
| 13 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 14 | Sonography in first trimester bleeding 显示文摘 | Manjiri D Carlos C | 2008 | J clin Ultras2008，36，6： | 1 |
| 15 | A new model for con- trol of systems with friction显示文摘 | Carlos C D W Olsson H Astrom K J | 1995 | IEEE Transactions on Automatic Control1995，40，3： | 1 |
| 16 | Vibro-acous- tie techniques to diagnose power transformers 显示文摘 | Bartoletti C Desiderio M Di Carlo D | 2004 | IEEE Trans on Power Delivery2004，19，1： | 1 |
| 17 | Preparation of charcoal from cherry stones显示文摘 | CARLOS J D V MANUEL G C VICENTE G S | 2006 | Applied Surface Science2006，252，17： | 1 |
| 18 | Surveillance of multi- drug-resistant gram-negative bacilli in a neonatal intensive care u nit:prominent role of cross transmission 显示文摘 | Mammina C Di Carlo P Cipolla D | 2007 | J Infect Control2007，35，22： | 1 |
| 19 | MOSES:A multiobjective optimization tool for engineering design显示文摘 | CARLOS A COELLO C CHRISTIANSEN A D | 1999 | Engineering Optimization1999，31，3： | 1 |
| 20 | Conservative treatment by uterine artery embolization of a 12 week cervical ectopie pregnancy 显示文摘 | NAPPI C D' ELlA A DI CARLO C | 1999 | Hum Reprod1999，14，4： | 1 |
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