|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An eighteen-month follow-up study on the effects of Intravitreal Dexamethasone Implant in diabetic macular edema refractory to anti-VEGF therapy显示文摘AIM: To evaluate the long-term efficacy and safety of dexamethasone implants in subjects affected by diabetic macular edema(DME) resistant to anti-vascular endothelial growth factor(VEGF) therapy.METHODS: Thirty-two DME patients were enrolled.A700 microgram slow release Intravitreal Dexamethasone Implant(Ozurdex~) was placed in the vitreous cavity.All patients were followed for 18 mo.Best-corrected visual acuity(BCVA) measured with Early Treatment Diabetic Retinopathy Study(ETDRS) and central macular thickness(CMT) exams were carried out at baseline(T0)and after 1(T1),3(T3),4(T4),6(T6),9(T9),12(T12),15(T15),and 18mo(T18) post injection. RESULTS: Repeated measures ANOVA showed an effect of treatment on ETDRS(P<0.0001).Post hoc analyses revealed that ETDRS values were significantly increased at T1,T3,T4,T9,and T15(P <0.001) as compared to baseline value(T0).At T6,T12,and T18,ETDRS values were still statistically higher than baseline(P<0.001 vs T0).However,at these time points,we observed a trend to return to baseline conditions.ANOVA also showed an effect of treatment(P <0.0001).CMT decreased significantly at T1,T3,T4,T9,and T15(P<0.001).At T6(P<0.01),T12 and T18(P<0.001) CMT was also significantly lower than T0 although a trend to return to the baseline conditions was also observed.CONCLUSION: Our findings demonstrate that Intravitreal Dexamethasone Implant is a good option to improveBCVA and CMT in DME patients resistant to anti-VEGF therapy.Our data also show that the use of drugs administered directly into the vitreous allows achieving appropriate and long-lasting concentration at the site of disease without systemic side effects. | Fernanda Pacella Maria Rosaria Romano Paolo Turchetti Giovanna Tarquini Anna Carnovale Antonella Mollicone Alessandra Mastromatteo Elena Pacella | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 5 |
| 2 | Mortality in acutepancreatitis:is it an early or a late event显示文摘 | Carnovale A Rabitti PG Manes G | 2005 | JOP2005，6，5： | 1 |
| 3 | On the relationship between human papillomavirus vaccine and autoimmune disea- ses 显示文摘 | Pellegrino P Carnovale C Pozzi M | 2014 | Autoimmun Rev2014，13，7： | 1 |
| 4 | Mortality in acute pan- creatitis: is it an early or a late even显示文摘 | Carnovale A Rabitti PG Manes G | 2005 | JOP2005，6，5： | 1 |
| 5 | Preparation of isoxazolidinyl nueleoside enantiomers by lipase-catalysed kinetic resolution 显示文摘 | Carnovale C Iannazzo D Nicolosi G | 2009 | Tetrahedron: Asymmetry2009，20，4： | 1 |
| 6 | Cychin D1 and cyclin E expression in malignant thyroid cell and in human thyroid carcinomas 显示文摘 | LAZZERESCHI D SAMBUCO L CARNOVALE C | 1998 | Int J Cancer1998，76，： | 1 |
| 7 | Mortality in acute pancreatitis: is it an early or a late event? 显示文摘 | Carnovale A Rabittl PG Manes G | 2005 | JOP2005，6，43： | 1 |
| 8 | Mortality in acute pancreatitis: is it an early or a late event?显示文摘 | Carnovale A Rabitti PG Manes G | 2005 | JOP2005，6，5： | 1 |
| 9 | Inhibition by interfer on A22b of rat liver regeneration:effect on ornith ine decar2 boxylase and total protein synthesis显示文摘 | Favre C Carnovale CE Monti JA | 2001 | Biochemical Pharmacology2001，61，15： | 1 |
| 10 | Martality in acute pancreatilis:is it an early or a late event显示文摘 | CARNOVALE A RABITTI PG MANES G | | 0，，05： | 1 |
| 11 | Epidemiological analysis on two decades of hospitalisations for meningitis in the United States 显示文摘 | Pellegrino P Carnovale C Perrone V | 2014 | Eur J Clin Microbi01 Infect Dis2014，33，9： | 1 |
| 12 | On the connec- tion between autoimmunity,tic disorders and obsessive- compulsive disorders: a meta-analysis on anti streptolysin O litres显示文摘 | Pozzi M Pellegrino D Carnovale C | 2014 | J Neuroimmune Pharmacol2014，9，5： | 1 |
| 13 | The role of ego network struc- ture in facilitating ego network innovations 显示文摘 | CARNOVALE S YENIYURT S | 2015 | Journal of Supply Chain Management2015，51，2： | 1 |
| 14 | Application of intra-and extracellular sugars and dimethylsulfoxide to human oocyte cryopreservation显示文摘 | Younis A Carnovale D Butler W | | 0，，： | 1 |
| 15 | Nitric oxide release and enhancement of lipid peroxidation in regeneration rat liver显示文摘 | Carnovale CE Scapini C Alvarez ML | 2000 | J Hepatol2000，32，： | 1 |
| 16 | Mortality in acute pancreatitis : is it an early or a late event显示文摘 | Carnovale A Rabitti PG Manes G | 2005 | J Pancreas2005，6，2： | 1 |
| 17 | Epidemiological analysis on two decades of hospitalisations formeningitis in the United States 显示文摘 | PELLEGRINO P CARNOVALE C PERRONE V | 2014 | Eur J Clin Microbiol InfectDis2014，33，9： | 1 |
| 18 | Inhibition by inter- feron alpha-2b of ::at liver regenerations Effect on ornithine deearboxylase and total protein synthesis 显示文摘 | Favre C Carnovale C E Monti J A | 2001 | Bioehem Phar- macol2001，61，12： | 1 |
| 19 | Mortality in acute pancreatitis:is it an early or a late event?显示文摘 | Carnovale A Rabitti PG Manes G | 2005 | JOP2005，6，5： | 1 |
| 20 | Application of intra-and extracellular sugars and dimethylsulfoxide to human oocyte cryopreservation显示文摘 | Younis A Carnovale D Butler W | | 0，，06： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员